Comparative Animal Models (CAM) Core

比较动物模型 (CAM) 核心

• 批准号: 10437781
• 负责人: Viravuth P Yin
• 金额: $ 24.33万
• 依托单位: MOUNT DESERT ISLAND BIOLOGICAL LAB
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10437781
• 关键词: Aging; Animal Husbandry; Animal Model; Animals; Behavioral; Biological; Biological Models; Biological Process; Biological Sciences; Biology; Caenorhabditis elegans; Cell Line; Centers of Research Excellence; Comparative Biology; Comparative Study; Cryopreservation; Development; Disease; Drosophila genus; Embryo; Ensure; Faculty; Fees; Fees and Charges; Foundations; Funding; Gene Transfer Techniques; Genetic Services; Genotype; Goals; Grant; Heart; Human; Infrastructure; Injury; International; Invertebrates; Kidney; Knowledge; Laboratories; Lead; Legal patent; Limb structure; Maintenance; Medical; Methods; Microinjections; Molecular; Mus; Natural regeneration; Organ; Oryziinae; Paper; Patients; Phase; Process; Protocols documentation; Publications; Quarantine; Regenerative Medicine; Regenerative capacity; Research; Research Personnel; Research Project Grants; Research Support; Resources; Salamander; Scientist; Services; Speed; Spinal Cord; Structure; Tissue Harvesting; Tissues; Training Programs; Transgenic Organisms; Translating; Vertebrates; Visit; Visual; Zebrafish; animal resource; base; comparative; cost; experimental study; human disease; human tissue; innovation; insight; laboratory curriculum; member; programs; recruit; regenerative; regenerative biology; repaired; research and development; small molecule; success; tissue repair

COMPARATIVE ANIMAL MODELS CORE PROJECT SUMMARY Regenerative medicine is the field of R&D and medical practice focused on repairing and replacing tissues and organs damaged by injury, disease and aging-associated degenerative changes. While most human tissues and organs have limited or no regenerative capacity, numerous diverse invertebrates and non- mammalian vertebrates readily repair and replace lost and damaged organs, including the heart, limbs, spinal cord and kidney, throughout their lives. Comparative studies of these animal models provide the opportunity to define the core cellular and molecular mechanisms underlying repair and regeneration processes. The ability to carry out research on regenerative processes in diverse animal models requires specialized facilities and expertise. The COBRE Comparative Animal Models (CAM) Core builds on MDIBL’s unique and increasingly important expertise in comparative animal biology to provide the animal resources necessary to grow and sustain the Kathryn Davis Center for Regenerative Biology and Medicine. During Phase I COBRE funding, the Core provided husbandry as well as associated specialized services such as embryo microinjection and transgenesis for multiple diverse animal models including zebrafish, Polypterus, medaka and C. elegans. The Core also provided the facilities and expertise needed to support the recruitment of two new Project Leaders using salamanders and Drosophila as model systems. Over the past four years, Core- supported research projects resulted in the publication of 26 papers by Phase I Project Leaders and 25 papers by non-COBRE faculty. This research in turn resulted in multiple firsts for the MDIBL including the discovery of three lead small molecules for regenerative medicine applications, six U.S. and international patent applications, one issued U.S. patent and the launch of the spinoff company Novo Biosciences. The overarching goal of the CAM Core is to support the research programs of COBRE Phase II Project Leaders and other investigators in the Davis Center and to help ensure the Center’s long-term sustainability. This will be accomplished by 1) providing Project Leaders and Davis Center faculty with animal husbandry resources as well as specialized experimental services, 2) establishing authentication services for genetic animal models and cell lines, and 3) expanding user fee-supported services to ensure long-term Core sustainability.

比较动物模型核心项目总结 再生医学是一个专注于修复和替换的研发和医疗实践领域 组织和器官因损伤、疾病和与衰老相关的退行性变化而受损。虽然大多数 人体组织和器官具有有限的再生能力或没有再生能力，许多不同的无脊椎动物和非 哺乳动物脊椎动物容易修复和替换丢失和受损的器官，包括心脏、四肢、脊髓、 脊髓和肾脏，在他们的一生中。这些动物模型的比较研究提供了机会， 定义修复和再生过程的核心细胞和分子机制。 在不同的动物模型中进行再生过程研究的能力需要 专业设施和专业知识。COBRE比较动物模型（CAM）核心建立在MDIBL的 在比较动物生物学方面的独特和日益重要的专业知识， 凯瑟琳·戴维斯再生生物学和医学中心（Kathryn Davis Center for Regenerative Biology and Medicine）在阶段 在COBRE的资助下，核心提供了饲养以及相关的专业服务，如胚胎 显微注射和转基因用于多种不同的动物模型，包括斑马鱼、多鳍鱼、青鳉 和C.优雅的核心小组还提供了必要的设施和专门知识， 新的项目领导人使用蝾螈和果蝇作为模型系统。在过去的四年里，核心- 支持的研究项目导致第一阶段项目领导人发表了26篇论文， 非COBRE教师。这项研究反过来又为MDIBL创造了多个第一，包括发现了 三个用于再生医学应用的领先小分子，六个美国和国际专利 申请，一项美国专利和分拆公司Novo Biosciences的推出。 CAM核心的首要目标是支持COBRE第二阶段的研究计划 戴维斯中心的项目负责人和其他调查人员，并帮助确保中心的长期 持续发展这将通过以下方式实现：1）为项目负责人和戴维斯中心的教师提供 畜牧业资源和专业化实验服务; 2）建立认证体系 为遗传动物模型和细胞系提供服务，3）扩大用户付费服务，以确保 长期的可持续性。