Administrative Core

核心摘要 该计划项目补助金（PPG）是一项高度综合的努力，汇集了科学家与广泛的 了解食管疾病中壁力学紊乱的作用。PPG将测试 假设食管疾病和相关症状严重程度主要与 食管壁的扩张性受损，这是通过各种细胞和分子介导的 在食管壁的反应和潜在的内脏高敏感性和过度警觉调制。 鉴于这一全面的方法，已经设计了四项针对研究科学领域的研究 从动物模型的离体研究到使用转化生理学的人体体内研究， 辅以计算机模拟模型和患者报告结局的自然评估。项目1将寻求 以确定改变食管壁扩张性的分子机制。项目2将测试 对体积膨胀的反应改变是食管疾病的关键因素的假说。项目3 将开发和完善药团输送的计算机模拟模型，重点关注食道扩张性的异常。 项目4将量化团注输送机制、食管扩张性和 调节食管症状的心理因素（项目4）。这些项目将得到两个 独特的核心;生物生理建模核心（CORE B）和生物储存库和组织材料 表征核心（核心C）。四个项目之间的合作与协作， 核心成果将通过计划项目和核心成果团队之间的团队合作来实现， 行政核心将主要负责通过以下五个方面协调这些互动： 相关的具体目标：目标1。支持交流、分享材料和传播 项目研究者、核心领导者、合作研究者、内部和 外部咨询委员会和机构核心。 目标二。为项目和核心领导人提供财务和监管监督，并协调其 与机构核心服务的互动。目标3：协调数据收集、数据安全和分析 项目和核心伦理委员会之间的努力，以监测对机构政策的遵守情况，确保患者 保密性，并使各个PPG组件与总体PPG时间轴保持一致。目标4。到 向其他机构传播项目调查人员的调查结果和项目核心评价成果的进展情况， 研究人员和促进讨论新的方法来研究食管壁力学。目标5。到 协调行政任务，如IRB提交和NIDDK报告生成，并组织 记录，以最大限度地提高PPG效率，以及患者招募和保留。

CORE SUMMARY This Program Project Grant (PPG) is a highly integrated effort to bring together scientists with a broad spectrum of expertise to understand the role of disordered wall mechanics in esophageal disease. The PPG will test the hypothesis that esophageal disease and associated symptom severity are primarily linked to abnormalities of impaired distensibility of the esophageal wall and that this is mediated through various cellular and molecular responses in the esophageal wall and modulated by underlying visceral hypersensitivity and hypervigilance. Given this comprehensive approach, four studies have been designed that target the gamut of research science from ex-vivo studies in animal models to in-vivo studies in humans using translational physiology that will be complemented by in-silico models and in-natura assessments of patient reported outcomes. Project 1 will seek to determine the molecular mechanisms that alter distensibility of the esophageal wall. Project 2 will test the hypothesis that an altered response to volumetric distention is a crucial factor in esophageal disease. Project 3 will develop and refine in-silico models of bolus transport that focus on abnormalities in esophageal distensibility. Project 4 will quantify the interaction between bolus transport mechanics, esophageal distensibility and psychological factors in modulating esophageal symptoms (Project 4). These projects will be supported by two unique COREs; the Biophysiologic Modeling Core (CORE B) and the Biorepository and Tissue Material Characterization CORE (CORE C). The cooperation and collaboration between the four projects and the two COREs will be achieved through teamwork between the Program Project and the CORE teams and the Administrative CORE will bear the primary responsibility for coordinating these interactions through five interrelated specifics aims: Aim 1. To support communication, sharing of materials and dissemination of information between the Project Investigators, the CORE Leaders, Collaborating investigators, the Internal and External Advisory Committees and the Institutional CORES. Aim 2. To provide financial and regulatory oversight of the Project and CORE Leaders and coordinate their interactions with Institutional CORE Services. Aim 3. To coordinate data collection, data security, and analysis efforts between the Projects and COREs to monitor adherence with institutional policies, ensure patient confidentiality, and keep individual PPG Components on track with the overall PPG timeline. Aim 4. To disseminate findings of the project investigators and progress of the project COREs to other institutions and investigators and facilitate discussion of new approaches to research of esophageal wall mechanics. Aim 5. To coordinate administrative tasks such as IRB submissions and NIDDK report generation, and organize documentation to maximize PPG efficiency, as well as patient recruitment and retention.