Administrative Core

核心摘要 该计划项目赠款(PPG)是一项高度整合的努力，旨在将来自不同领域的科学家聚集在一起 以了解紊乱的壁力学在食道疾病中的作用。PPG将测试 假设食道疾病和相关症状严重程度主要与食管壁异常有关。 食管壁的扩张性受损，这是通过多种细胞和分子介导的 食管壁的反应，并受到潜在的内脏过敏和高度警觉的调节。 鉴于这一综合方法，设计了四项针对研究科学色域的研究 从动物模型的体外研究到人类体内的研究，使用的翻译生理学将是 辅以计算机内模型和患者报告结果的自然评估。项目1将寻求 以确定改变食管壁膨胀性的分子机制。项目2将测试 这一假说认为，对容量膨胀的反应改变是食道疾病的一个关键因素。项目3 将开发和完善以食道扩张性异常为重点的团注运输的硅内模型。 项目4将量化丸剂运输机制、食道扩张性和 调节食道症状的心理因素(方案4)。这些项目将得到两个项目的支持 独特的核心；生物生理建模核心(核心B)以及生物储存库和组织材料 角色化核心(核心C)。四个项目和两个项目之间的合作和协作 核心将通过计划项目和核心团队之间的团队合作实现 行政核心将承担协调这些互动的主要责任，通过五个 相互关联的具体目标：目标1.支持交流、共享材料和传播 项目调查员、核心领导、合作调查员、内部和内部调查人员之间的信息 外部咨询委员会和机构核心。 目标2.为项目和核心领导提供财务和监管监督，并协调他们 与机构核心服务的互动。目标3.协调数据收集、数据安全和分析 项目和核心之间的努力，以监控对机构政策的遵守，确保耐心 保密性，并使各个PPG组件保持在总体PPG时间表的轨道上。目标4.目标 将项目调查员的调查结果和项目核心进展情况分发给其他机构和 研究人员和促进讨论食管壁力学研究的新方法。目标5.目标 协调IRB提交和NIDDK报告生成等行政任务，并组织 记录以最大限度地提高PPG效率，以及招募和留住患者。

CORE SUMMARY This Program Project Grant (PPG) is a highly integrated effort to bring together scientists with a broad spectrum of expertise to understand the role of disordered wall mechanics in esophageal disease. The PPG will test the hypothesis that esophageal disease and associated symptom severity are primarily linked to abnormalities of impaired distensibility of the esophageal wall and that this is mediated through various cellular and molecular responses in the esophageal wall and modulated by underlying visceral hypersensitivity and hypervigilance. Given this comprehensive approach, four studies have been designed that target the gamut of research science from ex-vivo studies in animal models to in-vivo studies in humans using translational physiology that will be complemented by in-silico models and in-natura assessments of patient reported outcomes. Project 1 will seek to determine the molecular mechanisms that alter distensibility of the esophageal wall. Project 2 will test the hypothesis that an altered response to volumetric distention is a crucial factor in esophageal disease. Project 3 will develop and refine in-silico models of bolus transport that focus on abnormalities in esophageal distensibility. Project 4 will quantify the interaction between bolus transport mechanics, esophageal distensibility and psychological factors in modulating esophageal symptoms (Project 4). These projects will be supported by two unique COREs; the Biophysiologic Modeling Core (CORE B) and the Biorepository and Tissue Material Characterization CORE (CORE C). The cooperation and collaboration between the four projects and the two COREs will be achieved through teamwork between the Program Project and the CORE teams and the Administrative CORE will bear the primary responsibility for coordinating these interactions through five interrelated specifics aims: Aim 1. To support communication, sharing of materials and dissemination of information between the Project Investigators, the CORE Leaders, Collaborating investigators, the Internal and External Advisory Committees and the Institutional CORES. Aim 2. To provide financial and regulatory oversight of the Project and CORE Leaders and coordinate their interactions with Institutional CORE Services. Aim 3. To coordinate data collection, data security, and analysis efforts between the Projects and COREs to monitor adherence with institutional policies, ensure patient confidentiality, and keep individual PPG Components on track with the overall PPG timeline. Aim 4. To disseminate findings of the project investigators and progress of the project COREs to other institutions and investigators and facilitate discussion of new approaches to research of esophageal wall mechanics. Aim 5. To coordinate administrative tasks such as IRB submissions and NIDDK report generation, and organize documentation to maximize PPG efficiency, as well as patient recruitment and retention.