(11) Diet Modification to Augment Radiation for Breast Cancer Brain Metastases
(11) 调整饮食以增强乳腺癌脑转移的放射治疗
基本信息
- 批准号:10439798
- 负责人:
- 金额:$ 34.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AKT Signaling PathwayAddressAdverse eventAffectApplications GrantsBiologicalBody mass indexBrainBreast Cancer ModelBreast Cancer PatientBreast Cancer TreatmentCaloric RestrictionCancer PrognosisCaringClinicalClinical TrialsClinical Trials DesignDataDietDiet ModificationDietary InterventionDiseaseEffectivenessEnergy IntakeEstrogensExcisionFastingFatigueGoalsGrantHeadacheHealthHypoxiaImpaired cognitionInsulin-Like Growth Factor ILaboratoriesLeadLesionLinkMalignant NeoplasmsMeasuresMemoryMemory LossMetabolicMetabolismMetastatic Neoplasm to the LungMetastatic malignant neoplasm to brainMetastatic toMethodsMicrometastasisModalityMolecularNausea and VomitingNeoplasm MetastasisNeurocognitiveNeurologicNotch Signaling PathwayOperative Surgical ProceduresOutcomePathway interactionsPatient-Focused OutcomesPatientsPharmaceutical PreparationsPlayPrimary NeoplasmPrognosisProgression-Free SurvivalsProteinsPublic HealthQuality of lifeRadiationRadiation ToxicityRecurrenceReportingResearchResistanceRoleSerum MarkersShort-Term MemorySignal PathwaySymptomsTestingTimeToxic effectTranslatingTrastuzumabTreatment EfficacyWeightWomanacute toxicityage relatedbrain tissuebreast cancer survivalcancer carecancer therapycytotoxicdietarydietary manipulationdisorder controleffective therapyempoweredfirst-in-humanimprovedimproved outcomein vivoinhibitorinnovationinsightinsulin secretionketogenic dietknock-downmalignant breast neoplasmmembermind controlneoplastic cellnew therapeutic targetnovelnovel therapeuticsnutritionobese patientsoverexpressionpatient subsetspre-clinicalpreventradiation responseresponsetargeted treatmenttherapy resistanttumortumor metabolismtumor microenvironmenttumor progression
项目摘要
Project Summary
In response to PQ11, “Through what mechanisms do diet and nutritional interventions affect the response to
cancer treatment?,” this proposal will determine that nutrition can be used to improve radiation (RT) response,
improve outcomes and decrease toxicity for breast cancer patients with brain metastases. Breast cancer is the
leading cause of brain metastases in women and is associated with a dismal prognosis despite standard
therapies including radiation or surgical resection. Local control of brain metastases confers better survival and
prevents neurological decline. To try and improve local control, novel targeted therapies have been added to
radiation (RT); most have unfortunately resulted in little improvement while adding significant toxicity. For the
first time, it will be determined if dietary modifications may play a role in the treatment of brain metastases
since one of the hallmarks of both metastases and tumor cell resistance to RT, is the dysregulation of cellular
metabolism. Our long-term goal is to 1) change the landscape of cancer care by empowering patients to use
dietary interventions to improve outcomes, and 2) to use the discoveries from this proposal to translate
findings. The objective of this grant is to determine if radiation efficacy can be increased for metastatic disease
without increasing toxicity, by using dietary manipulation. The central hypothesis is that an integrated
approach, one incorporating dietary changes, will alter key pro-survival pathways in metastatic tumor cells, to
improve local control and, therefore, patient survival. Our specific aims will test the following hypotheses:
(Aim1) Determine the contribution of dietary intervention on radiation effectiveness in treatment of breast
cancer brain metastases; (Aim 2) the IGF-1R/AKT signaling pathway axis is a key node, at least in some part,
in the biological response leading to the proposed molecular cytotoxic cooperation between dietary
modification and RT; (Aim 3) Determine the subset of breast cancer patients with brain metastases that benefit
from combined DMs and RT. This contribution is significant since it will establish that dietary modifications can
target pathways (ie IGF-1R/Akt) to modulate the radiation response and affect a positive clinical change. The
proposed research is innovative because diet has not been used as a “drug” during cancer therapy. This
proposal will provide insight into how dietary modifications can be used to affect the radiation response,
potential toxicity and outcomes in breast cancer patients with brain metastases.
项目总结
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
An Ex Vivo Brain Slice Model to Study and Target Breast Cancer Brain Metastatic Tumor Growth.
- DOI:10.3791/62617
- 发表时间:2021-09-22
- 期刊:
- 影响因子:0
- 作者:Ciraku L;Moeller RA;Esquea EM;Gocal WA;Hartsough EJ;Simone NL;Jackson JG;Reginato MJ
- 通讯作者:Reginato MJ
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Nicole L Simone其他文献
Nicole L Simone的其他文献
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{{ truncateString('Nicole L Simone', 18)}}的其他基金
Metabolic implications of radiation response in oligometastatic prostate cancer.
放射反应对寡转移性前列腺癌的代谢影响。
- 批准号:
10515453 - 财政年份:2022
- 资助金额:
$ 34.97万 - 项目类别:
Metabolic implications of radiation response in oligometastatic prostate cancer.
放射反应对寡转移性前列腺癌的代谢影响。
- 批准号:
10676868 - 财政年份:2022
- 资助金额:
$ 34.97万 - 项目类别:
(11) Diet Modification to Augment Radiation for Breast Cancer Brain Metastases
(11) 调整饮食以增强乳腺癌脑转移的放射治疗
- 批准号:
10206051 - 财政年份:2018
- 资助金额:
$ 34.97万 - 项目类别:
Diet Modification to Augment Radiation for Breast Cancer Brain Metastases
调整饮食以增强乳腺癌脑转移的放射治疗
- 批准号:
10260963 - 财政年份:2018
- 资助金额:
$ 34.97万 - 项目类别:
Mechanism of lung cancer resistance to tyrosine kinase inhibitor and radiation treatments
肺癌对酪氨酸激酶抑制剂和放射治疗的耐药机制
- 批准号:
10470829 - 财政年份:2018
- 资助金额:
$ 34.97万 - 项目类别:
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