SARS-CoV-2 Variant Testing
SARS-CoV-2 Variant Testing
批准号:
10446500
负责人:
Galit Alter
金额:
$34.82万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-08-17 至 2022-09-30
关键词:
AffinityAntibodiesAntibody AffinityAntibody ResponseAntigen PresentationAntigen-Antibody ComplexAntigen-Presenting CellsAntigensAntiviral AgentsAutomobile DrivingB-LymphocytesBindingBiologyCellsCharacteristicsComplementComplement ActivationComplement ReceptorDataDepositionDevelopmentDissectionEvolutionFailureFc ReceptorFutureGoalsHemagglutinationHumanHumoral ImmunitiesImmuneImmunityIndividualInfectionInfection preventionInflammationInfluenzaInnate Immune SystemLinkMeasuresMediatingMusNamesNational Institute of Allergy and Infectious DiseaseNatural Killer CellsPhagocytesPhagocytosisPlayReactionResearchRoleSamplingSeasonsShapesStructure of germinal center of lymph nodeT-LymphocyteVaccinatedVaccinationVaccine DesignVaccinesVariantVirusantibody-dependent cell cytotoxicitybasecase controlcohortcytotoxicitydesignepidemiology studyglobal healthimmune activationimmunoregulationinfluenza infectioninfluenza virus vaccineinnate immune functioninsightmouse modelneutralizing antibodynext generationnovelnovel vaccinespathogenrecruitseasonal influenzatooluniversal influenza vaccinevaccine developmentvaccine responsevaccine-induced antibodiesvaccine-induced immunity
中文摘要
摘要
英文摘要
Abstract
The robust protection conferred by emerging EUA approved SARS-CoV-2 vaccines represents a critical milestone in COVID-19 vaccine development. However, the emergence of variants has inspired renewed concern related to the protective efficacy of currently approved vaccines, which lose neutralizing potency against some variants. However, emerging data suggest that antibody functions, beyond neutralization, that emerge early after vaccination and that persist even with a loss of neutralization, may contribute to protection from disease. Thus, here we aim to profile the evolution of the breadth of the VOC-specific Fc-effector functions of vaccine induced antibodies across vaccine platforms. Specifically, we aim to profile the subclass, isotypes, Fc-receptor binding, complement depositing function, cellular cytotoxicity, opsinophagocytic activity, degranulation, and mucus trapping days after vaccination compared to convalescent individuals. These data will be compared to breakthrough infection cases from Novavax (& Medicago) and J&J.
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会议论文
Systems Serology Core
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批准号:10616544
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项目类别:
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资助金额:$29.45万
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财政年份:2021
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负责人:Galit Alter
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依托单位:
Systems Serology Core
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批准号:10203487
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项目类别:
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资助金额:$39.61万
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财政年份:2021
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负责人:Galit Alter
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依托单位:
Systems Serology Core
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批准号:10449292
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项目类别:
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资助金额:$40.74万
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财政年份:2021
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负责人:Galit Alter
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依托单位:
Defining humoral correlates of immunity against COVID-19
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批准号:10265799
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项目类别:
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资助金额:$35.56万
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财政年份:2020
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负责人:Galit Alter
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依托单位:
Immunologic Signatures of SARS-CoV-2 Vaccination and Disease
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批准号:10221341
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资助金额:$147.8万
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财政年份:2020
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Multiplexed Antigen-Specific Antibody Fc Profiling on a Chip for Point-of-Care Diagnosis of TB in HIV-infected Children
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财政年份:2020
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负责人:Galit Alter
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依托单位:
Antibody Optimization Core
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批准号:10158451
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项目类别:
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资助金额:$68.97万
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财政年份:2019
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负责人:Galit Alter
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依托单位:
Antibody Optimization Core
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批准号:10402341
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项目类别:
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资助金额:$69.29万
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财政年份:2019
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负责人:Galit Alter
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依托单位:
Antibody Optimization Core
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批准号:10617741
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项目类别:
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资助金额:$62.43万
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财政年份:2019
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负责人:Galit Alter
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依托单位:
Core B
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批准号:10339364
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项目类别:
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资助金额:$99.39万
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财政年份:2018
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负责人:Galit Alter
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依托单位:
Killing the Reservoir with Antibodies
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批准号:9197410
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项目类别:
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资助金额:$48.61万
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财政年份:2015
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负责人:Galit Alter
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依托单位:
Killing the Reservoir with Antibodies
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批准号:8656251
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项目类别:
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资助金额:$23.56万
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财政年份:2013
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负责人:Galit Alter
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依托单位:
Tuning Fc-effector functions of HIV-specific antibodies
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批准号:8408897
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项目类别:
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资助金额:$60.99万
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财政年份:2012
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负责人:Galit Alter
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依托单位:
Tuning Fc-effector functions of HIV-specific antibodies
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批准号:8874097
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项目类别:
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资助金额:$87.64万
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财政年份:2012
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负责人:Galit Alter
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依托单位:
Tuning Fc-effector functions of HIV-specific antibodies
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批准号:8691723
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项目类别:
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资助金额:$84.27万
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财政年份:2012
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负责人:Galit Alter
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依托单位:
Tuning Fc-effector functions of HIV-specific antibodies
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批准号:8496714
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项目类别:
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资助金额:$67.25万
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财政年份:2012
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负责人:Galit Alter
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依托单位:
The Innate Immune Signals on B Cells that Induce ADCC Antibodies
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批准号:8332408
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财政年份:2011
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负责人:Galit Alter
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依托单位:
The role of NK cells during acute HCV infection and antiviral therapy
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批准号:7919782
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资助金额:$17.12万
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财政年份:2010
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负责人:Galit Alter
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依托单位:
Cytolytic antibodies:Bridging the gap between the innate and adaptive immune resp
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批准号:8072923
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项目类别:
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资助金额:$43.39万
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财政年份:2010
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负责人:Galit Alter
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依托单位:
Cytolytic antibodies:Bridging the gap between the innate and adaptive immune resp
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批准号:7686615
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项目类别:
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资助金额:$44.13万
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财政年份:2009
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负责人:Galit Alter
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依托单位:
海外基金