Systems Serology Core
Systems Serology Core
批准号:
10449292
负责人:
Galit Alter
金额:
$40.74万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-07-12 至 2026-04-30
关键词:
AddressAdultAffectAntibodiesAntibody ResponseAreaAutologousBenchmarkingBiological AssayBiophysicsBirthCellsCollectionDataDevelopmentEngineeringEnsureEnvironmentFingerprintGenerationsGoalsHumanHuman ResourcesHumoral ImmunitiesImmuneImmune responseImmune systemImmunityImmunologicsInfantInfant HealthInfectionInfrastructureInstitutesInterventionInvestigationKnowledgeLaboratoriesLeadershipLifeMaternal antibodyMaternally-Acquired ImmunityMonitorNatureNeonatalNewborn InfantPregnancyProtocols documentationReagentResearchResourcesRoleRunningSamplingSerologyStandardizationSystemTechnical ExpertiseTechnologyTherapeuticTrainingVaccinationVaccinesWorkantibody testconditioninghigh standardimprovedin uterolaboratory experiencematernal vaccinationneonatal immunityneonatenew technologynext generationnovelprogramsresponsesuccesssynergismtool
中文摘要
核心1 -系统血清学核心-摘要
越来越多的数据表明,在怀孕和生命早期,免疫系统发生了巨大的变化。然而,这些
免疫扰动改变对疫苗接种或感染的免疫应答还没有完全确定。下
核心1、深入全面的表征将对体液免疫应答进行提升
我们对免疫系统在整个怀孕过程中变化的机制的理解,
变化影响对疫苗的反应,以及婴儿如何从母体免疫中受益,
疫苗。具体来说,核心1将利用和发展系统血清学,以广泛和深入地探讨自然
体液免疫反应的样品节省的方式,通过开发的多重抗体
剖析方法。此外,核心1将开发低通量功能测定,以探测相互作用
抗体和宿主先天免疫细胞之间的关系,以完全自体的方式,以确定
在怀孕和生命早期改变抗体和细胞状态。因此,核心1将深入询问和定义
在整个妊娠期、出生时和整个婴儿早期的体液免疫变化。核心领导
将提供所有的专业知识,基础设施,试剂,人员和培训,以确保高效,
在项目1和2下成功分析和部署这项技术,并支持生成
项目2和项目4的数据。因此,该核心的主要作用是提供领导和技术专长,
为了确保抗体检测以标准方式运行,新技术从本核心发展到
支持整个联合体的需求,并确保联合体随时了解最新发展
评估抗体反应。
英文摘要
CORE 1 – SYSTEMS SEROLOGY CORE – ABSTRACT
Accumulating data points to dramatic immunologic changes during pregnancy and early life. However, how these
immune perturbations alter the immune response to vaccination or to infection have yet to be fully defined. Under
Core 1, in depth comprehensive characterization will be performed on the humoral immune response to improve
our understanding of the mechanisms by which the immune system changes throughout pregnancy, how these
changes affect responses to vaccines and how infants benefit from maternal immunity and in turn respond to
vaccines. Specifically, Core 1 will exploit and evolve Systems Serology to broadly and deeply probe the nature
of the humoral immune response in a sample sparing manner, via the development of multiplexed-antibody
profiling approaches. Additionally Core 1 will develop lower-throughput functional assays to probe the interaction
between antibodies and host-innate immune cells, in a fully autologous fashion, to define the overall impact of
altered antibody and cellular state in pregnancy and early life. Thus Core 1 will deeply interrogate and define
changes in humoral immunity throughout pregnancy, at birth, and throughout early infant life. The Core leader
will provide all the expertise, infrastructure, reagents, personnel, and training, to ensure the efficient and
successful analysis and deployment of this technology under Projects 1 & 2, as well as support in generating
data for Projects 2 & 4. Thus the main role of this Core is to provide the leadership and the technical expertise
to ensure that antibody assays are run in a standard fashion, that novel technologies evolve from this Core to
support the needs of the overall Consortium, and that the Consortium is kept abreast of the latest developments
in assessing antibody responses.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
SARS-CoV-2 Variant Testing
-
批准号:10446500
-
项目类别:
-
资助金额:$34.82万
-
财政年份:2021
-
负责人:Galit Alter
-
依托单位:
Systems Serology Core
-
批准号:10616544
-
项目类别:
-
资助金额:$29.45万
-
财政年份:2021
-
负责人:Galit Alter
-
依托单位:
Systems Serology Core
-
批准号:10203487
-
项目类别:
-
资助金额:$39.61万
-
财政年份:2021
-
负责人:Galit Alter
-
依托单位:
Defining humoral correlates of immunity against COVID-19
-
批准号:10265799
-
项目类别:
-
资助金额:$35.56万
-
财政年份:2020
-
负责人:Galit Alter
-
依托单位:
Immunologic Signatures of SARS-CoV-2 Vaccination and Disease
-
批准号:10221341
-
项目类别:
-
资助金额:$147.8万
-
财政年份:2020
-
负责人:Galit Alter
-
依托单位:
Multiplexed Antigen-Specific Antibody Fc Profiling on a Chip for Point-of-Care Diagnosis of TB in HIV-infected Children
-
批准号:10159844
-
项目类别:
-
资助金额:$96.06万
-
财政年份:2020
-
负责人:Galit Alter
-
依托单位:
Antibody Optimization Core
-
批准号:10158451
-
项目类别:
-
资助金额:$68.97万
-
财政年份:2019
-
负责人:Galit Alter
-
依托单位:
Antibody Optimization Core
-
批准号:10402341
-
项目类别:
-
资助金额:$69.29万
-
财政年份:2019
-
负责人:Galit Alter
-
依托单位:
Antibody Optimization Core
-
批准号:10617741
-
项目类别:
-
资助金额:$62.43万
-
财政年份:2019
-
负责人:Galit Alter
-
依托单位:
Core B
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批准号:10339364
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项目类别:
-
资助金额:$99.39万
-
财政年份:2018
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负责人:Galit Alter
-
依托单位:
Killing the Reservoir with Antibodies
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批准号:9197410
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项目类别:
-
资助金额:$48.61万
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财政年份:2015
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负责人:Galit Alter
-
依托单位:
Killing the Reservoir with Antibodies
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批准号:8656251
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项目类别:
-
资助金额:$23.56万
-
财政年份:2013
-
负责人:Galit Alter
-
依托单位:
Tuning Fc-effector functions of HIV-specific antibodies
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批准号:8874097
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项目类别:
-
资助金额:$87.64万
-
财政年份:2012
-
负责人:Galit Alter
-
依托单位:
Tuning Fc-effector functions of HIV-specific antibodies
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批准号:8408897
-
项目类别:
-
资助金额:$60.99万
-
财政年份:2012
-
负责人:Galit Alter
-
依托单位:
Tuning Fc-effector functions of HIV-specific antibodies
-
批准号:8691723
-
项目类别:
-
资助金额:$84.27万
-
财政年份:2012
-
负责人:Galit Alter
-
依托单位:
Tuning Fc-effector functions of HIV-specific antibodies
-
批准号:8496714
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项目类别:
-
资助金额:$67.25万
-
财政年份:2012
-
负责人:Galit Alter
-
依托单位:
The Innate Immune Signals on B Cells that Induce ADCC Antibodies
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批准号:8332408
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项目类别:
-
资助金额:$43.79万
-
财政年份:2011
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负责人:Galit Alter
-
依托单位:
The role of NK cells during acute HCV infection and antiviral therapy
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批准号:7919782
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项目类别:
-
资助金额:$17.12万
-
财政年份:2010
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负责人:Galit Alter
-
依托单位:
Cytolytic antibodies:Bridging the gap between the innate and adaptive immune resp
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批准号:8072923
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项目类别:
-
资助金额:$43.39万
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财政年份:2010
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负责人:Galit Alter
-
依托单位:
Anergizing effect of NK cell receptor expression on HIV-specific CD8+ T cells
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批准号:7900192
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项目类别:
-
资助金额:$11.87万
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财政年份:2009
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负责人:Galit Alter
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依托单位:
海外基金