CISNET Lung Disparities Supplement

项目摘要摘要 肺癌是美国第三大常见癌症，也是导致癌症的首要原因 死亡。尽管美国的肺癌发病率和死亡率正在下降，但重要的是 性别和种族的差异仍然存在。尽管吸烟率比其他种族低 在美国，黑人男性面临着肺癌发病率和死亡率最高的问题。 同样，在美国，黑人女性的吸烟率低于白人女性，但 肺癌发病率和死亡率与白人女性和更高的肺癌相当 这一比例高于其他种族/民族。组织学上的肺癌发病率也有很大的不同 种族/民族，黑人男性和女性患鳞状细胞癌的风险更高 而不是其他种族/民族群体。考虑到观察到的筛查效果的异质性， 组织类型，这些差异可能会影响肺癌筛查的有效性 黑人人口。肺癌自然病程的计算机网络模型是研究肺癌自然病程的有用工具 了解预防性干预措施(控烟和筛查)对肺部的影响 在人口层面上的癌症。我们建议扩展和使用其中一个CISNet肺模型， 美国非西班牙裔黑人的肺癌发病率和死亡率模型 人口(NHB)，2)决定沿癌症控制的各种因素的贡献 NHB中肺癌死亡率相对于整个人群的差异的连续体，3) 评估筛查和其他干预措施对减轻肺癌负担的潜在影响 以及NHB方面存在的差距。

Project Summary Abstract Lung cancer is the third most common cancer in the U.S and the leading cause of cancer deaths. Although lung cancer incidence and mortality in the US are decreasing, important differences by gender and race remain. Despite having lower smoking rates than other racial groups, Black men face the highest incidence and mortality rate of lung cancer in the US. Similarly, Black women have lower smoking rates than White women in the US, but have comparable lung cancer incidence and mortality rates to White women and higher lung cancer rates than other racial/ethnic groups. Lung cancer incidence by histology also differs greatly by race/ethnicity, with Black men and women being at higher risk for squamous cell carcinoma than other racial/ethnic groups. Given the observed heterogeneity in screening efficacy by histological type, these differences could affect the effectiveness of lung cancer screening in the Black population. The CISNET models of lung cancer natural history have been useful tools to understand the impacts of preventive interventions (tobacco control and screening) on lung cancer at a population level. We propose to extend and use one of the CISNET Lung models, MichiganLung, to 1) model lung cancer incidence and mortality in the US Non-Hispanic Black population (NHB), 2) determine the contributions of various factors along the cancer control continuum to disparities in lung cancer mortality in NHB relative to the whole population, and 3) evaluate the potential impact of screening and other interventions to reduce lung cancer burden and existing disparities in NHB.