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Comparative Modeling of Lung Cancer Prevention, Early Detection and Treatment Interventions

肺癌预防、早期检测和治疗干预的比较模型

基本信息

批准号：
10687334
负责人：
THEODORE R HOLFORD
金额：
$ 4.26万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-08 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10687334
关键词：
Accounting Adopted Adoption Advisory Committees American College of Radiology Biological Markers Cancer Burden Cancer Etiology Cancer Intervention and Surveillance Modeling Network Cessation of life Cigarette Data Decision Making Development Early Diagnosis Early treatment Effectiveness Electronic cigarette Future Genetic Geographic Locations Histology Immunotherapy Incidence Individual Intervention Joints Lung Malignant neoplasm of lung Modeling Outcome Policies Population Population Research Precision therapeutics Prevalence Preventive service Process Recording of previous events Registries Research Research Personnel Resources Risk Risk Factors Schedule Screening Result Smoking Smoking History Source Taxation Taxes Tobacco Tobacco 21 policies United States Work budget impact cancer recurrence cancer survival cancer therapy comparative cost effectiveness cost-effectiveness evaluation electronic cigarette use fight against health warning implementation barriers innovation low and middle-income countries low dose computed tomography lung basal segment lung cancer prevention lung cancer screening mortality personalized approach population health programs public policy on tobacco screening screening guidelines smoking cessation smoking initiation sociodemographic factors targeted treatment tobacco control tobacco products tobacco screening tool working group

项目摘要

Project Summary Abstract Lung cancer remains the leading cause of cancer related mortality in the US and globally— responsible for ~1.8 million deaths annually. As collaborative investigators of the Cancer Intervention and Surveillance Modeling Network (CISNET) Lung Working Group (LWG), we have contributed to the development of US national strategies for reducing the lung cancer burden by quantifying the impact of tobacco control on smoking, lung cancer, and overall mortality, and by evaluating the population benefits and harms of lung cancer screening in the US. Due to ongoing reductions in smoking in the US, lung cancer mortality is projected to continue declining. However, lung cancer is still expected to result in over 4 million deaths over the next 50 years. Thus, in addition to tobacco control efforts, a focus on early detection and treatment interventions will be critical to further reduce the lung cancer burden in the US. Moreover, as new tobacco products, such as e-cigarettes (e-cigs), become more popular, there are concerns that the gains achieved in the fight against smoking could reverse. We propose to continue our work and extend our models to assess the impact of 1) future tobacco control interventions in the ever-changing tobacco market landscape, 2) improvements in lung cancer screening and other emerging early detection strategies, 3) innovations in lung cancer treatment, and importantly, 4) their synergistic interactions on lung cancer rates and overall mortality in the US and globally.

项目摘要