Unmodified and Post Translationally Modified CD4+ and CD8+ T cell Epitopes in Rheumatoid Arthritis

类风湿关节炎中未修饰和翻译后修饰的 CD4 和 CD8 T 细胞表位

• 批准号: 10441011
• 负责人: RYAN BENTON
• 金额: $ 107.91万
• 依托单位: BENAROYA RESEARCH INST AT VIRGINIA MASON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441011
• 关键词: Address; Affect; Antibodies; Antigens; Autoantigens; Autoimmune Diseases; Binding; Biological Assay; CD8-Positive T-Lymphocytes; Communities; Computer software; Contracts; Databases; Diagnostic; Disease; Epitopes; Human; Immune; In Vitro; Joints; Knowledge; Mediating; Pathogenesis; Research; Resources; Rheumatoid Arthritis; Rheumatoid Factor; Role; Support Contracts; T cell response; T-Cell Immunologic Specificity; T-Lymphocyte; T-Lymphocyte Epitopes; Tissues; Validation; citrullinated protein; data tools; immunogenicity; multidisciplinary; peripheral blood; recruit; seropositive; validation studies

This contract supports highly interactive, multi-disciplinary teams, whose research efforts are focused on large-scale discovery of T cell immune epitopes, validation of these epitopes, and defining their role in immune protection or immune-mediated pathogenesis in humans. Milestones include: 1) epitope identification; 2) in vitro epitope validation studies with primary human T cells to demonstrate the immunogenicity/antigenicity or diagnostic potential of all newly defined T cell epitopes shown to bind to classical or non-classical MHC molecules; and 3) submission of all epitope information and computer software to the Immune Epitope Database and Analysis Resource to facilitate access and use of the data and tools by the broader research community.

该合同支持高度互动的多学科团队，他们的研究重点是大规模发现T细胞免疫表位，验证这些表位，并确定它们在人类免疫保护或免疫介导的发病机制中的作用。里程碑包括：1)表位识别；2)对原代人类T细胞进行体外表位验证研究，以证明所有新定义的与经典或非经典MHC分子结合的T细胞表位的免疫原性/抗原性或诊断潜力；以及3)向免疫表位数据库和分析资源提交所有表位信息和计算机软件，以促进更广泛的研究社区访问和使用数据和工具。