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Large Scale T Cell Epitope Discovery: Proteome-wide characterization of T cell epitopes from Mycobacterium tuberculosis in vaccination and active infection

Large Scale T Cell Epitope Discovery: Proteome-wide characterization of T cell epitopes from Mycobacterium tuberculosis in vaccination and active infection
大规模 T 细胞表位发现：疫苗接种和主动感染中结核分枝杆菌 T 细胞表位的全蛋白质组表征
批准号：
10441009
负责人：
Bjoern Peters
金额：
$91.88万
依托单位：
LA JOLLA INSTITUTE FOR IMMUNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
项目状态：
已结题
起止时间：
2019-09-30 至 2022-09-29
来源：
https://reporter.nih.gov/project-details/10441009
关键词：
AllelesAntigen-Presenting CellsBindingBiological AssayCommunitiesComputer softwareDatabasesDiagnosticDiseaseEpitopesHumanImmuneIn VitroIndividualInfectionLibrariesMediatingMycobacterium tuberculosisPathogenesisPeptidesProteomeResearchResourcesRoleSupport ContractsT-LymphocyteT-Lymphocyte EpitopesVaccinatedVaccinationValidationcohortdata toolsimmunogenicitymultidisciplinaryvalidation studies

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中文摘要
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英文摘要
This contract supports highly interactive, multi-disciplinary teams, whose research efforts are focused on large-scale discovery of T cell immune epitopes, validation of these epitopes, and defining their role in immune protection or immune-mediated pathogenesis in humans. Milestones include: 1) epitope identification; 2) in vitro epitope validation studies with primary human T cells to demonstrate the immunogenicity/antigenicity or diagnostic potential of all newly defined T cell epitopes shown to bind to classical or non-classical MHC molecules; and 3) submission of all epitope information and computer software to the Immune Epitope Database and Analysis Resource to facilitate access and use of the data and tools by the broader research community.
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THE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCE
THE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCE
THE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCE
THE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCE
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