课题基金 / 基金详情

Large Scale T Cell Epitope Discovery: Proteome-wide characterization of T cell epitopes from Mycobacterium tuberculosis in vaccination and active infection

Large Scale T Cell Epitope Discovery: Proteome-wide characterization of T cell epitopes from Mycobacterium tuberculosis in vaccination and active infection
大规模 T 细胞表位发现：疫苗接种和主动感染中结核分枝杆菌 T 细胞表位的全蛋白质组表征
批准号：
10610271
负责人：
Bjoern Peters
金额：
$95.26万
依托单位：
LA JOLLA INSTITUTE FOR IMMUNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
项目状态：
已结题
起止时间：
2019-09-30 至 2023-09-29
来源：
https://reporter.nih.gov/project-details/10610271
关键词：
AllelesAntigen-Presenting CellsBindingBiological AssayCommunitiesComputer softwareDatabasesDiagnosticDiseaseEpitopesHumanImmuneIn VitroIndividualInfectionLibrariesMediatingMycobacterium tuberculosisPathogenesisPeptidesProteomeResearchResourcesRoleSupport ContractsT-LymphocyteT-Lymphocyte EpitopesVaccinatedVaccinationValidationcohortdata toolsimmunogenicitymultidisciplinaryvalidation studies

项目摘要

项目成果

Bjoern Peters的其他基金

相似基金

相关文献

中文摘要
翻译
该合同支持高度互动的多学科团队，其研究工作重点是大规模发现T细胞免疫表位，验证这些表位，并确定它们在人类免疫保护或免疫介导的发病机制中的作用。里程碑包括：1）表位鉴定; 2）用原代人T细胞进行体外表位验证研究，以证明显示与经典或非经典MHC分子结合的所有新定义的T细胞表位的免疫原性/抗原性或诊断潜力;以及3）将所有表位信息和计算机软件提交给免疫表位数据库和分析资源，以促进更广泛的研究团体访问和使用数据和工具。
英文摘要
This contract supports highly interactive, multi-disciplinary teams, whose research efforts are focused on large-scale discovery of T cell immune epitopes, validation of these epitopes, and defining their role in immune protection or immune-mediated pathogenesis in humans. Milestones include: 1) epitope identification; 2) in vitro epitope validation studies with primary human T cells to demonstrate the immunogenicity/antigenicity or diagnostic potential of all newly defined T cell epitopes shown to bind to classical or non-classical MHC molecules; and 3) submission of all epitope information and computer software to the Immune Epitope Database and Analysis Resource to facilitate access and use of the data and tools by the broader research community.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
THE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCE
THE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCE
THE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCE
THE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCE
海外基金