Novel 10.5 T deuterium-based MRS/I method to measure brain metabolism

测量脑代谢的新型 10.5 T 氘 MRS/I 方法

• 批准号: 10442075
• 负责人: Wolfgang Bogner
• 金额: $ 53.61万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10442075
• 关键词: Acetates; Back; Brain; Brain Diseases; Brain region; Calibration; Chemicals; Citric Acid Cycle; Data; Dementia; Deuterium; Development; Fostering; Future; Glucose; Glutamates; Glutamine; Glycolysis; Goals; Gold; Human; Human body; Image; Imaging Device; Label; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Measurement; Measures; Mental disorders; Metabolic; Metabolic Pathway; Metabolism; Methods; Monitor; Neurosciences; Nutrient; Pathogenesis; Pathologic; Pathology; Performance; Pharmaceutical Preparations; Physiological; Positron-Emission Tomography; Protons; Rattus; Research; Research Project Grants; Scanning; Sensitivity and Specificity; Specificity; Spectrum Analysis; Techniques; Technology; Tissues; Translating; Translations; Work; base; brain metabolism; gamma-Aminobutyric Acid; healthy volunteer; human data; imaging approach; imaging modality; improved; in vivo; magnetic field; metabolic imaging; metabolic rate; metabolome; novel; sensor; spectroscopic imaging; success; tool

PROJECT SUMMARY/ABSTRACT Pathological changes in the human metabolome are ubiquitous and fundamental to the pathogenesis of all brain disorders including cancer, dementia, and psychiatric disorders. This project proposes to develop a non-invasive magnetic resonance imaging tool to interrogate human brain metabolism in an unprecedented way using the world’s first ultra-high field 10.5 T whole-body human MRI scanner and a novel dynamic deuterium to proton exchange (2H-to-1H) MRS approach. Two complimentary strategies, single-voxel spectroscopy (SVS) and MR spectroscopic imaging (MRSI) will be developed in parallel. 2H-to-1H MRS will be able to quantify and image concentrations and metabolic fluxes in the human brain in vivo through the entire metabolic pathway from a single scan. In the first part of this project, we will utilize state-of-the-art MR-compatible sensors and calibration scans to accurately characterize spatial field inhomogeneities and monitor scanner- and subject-dependent temporal instabilities at 10.5 T. In the second part, we will develop and validate a novel dynamic 1H-SVS technique at 10.5 T with the focus on maximizing the range of reproducibly detectable metabolites by targeting a single accurately defined brain region. In the third part, we will establish a new highly accurate and robust dynamic 1H-MRSI method for 10.5 T, which will trade-off the ability to interrogate a broad range of metabolites for the ability to image some of them over the entire brain. In the final part, we will proof the feasibility of measuring human brain metabolism in vivo non-invasively via dynamic 2H-to-1H MRS at 10.5 T and 7 T using 2H-labled glucose and estimate experimental and physiologic variability. We will compare the performance of our novel tool to deuterium metabolic imaging. Successful completion of this project will provide a powerful tool for neuroscience and metabolic research.

项目摘要/摘要 人类代谢组的病理变化无处不在，是ALL发病的基础 疾病包括癌症、痴呆症和精神障碍。本项目建议开发一种非侵入性 磁共振成像工具，以前所未有的方式询问人类的大脑新陈代谢使用 世界上第一台超高场10.5T人体核磁共振扫描仪和一种新的动态重氢-质子 交换(2H到1H)MRS方法。两种互补策略，单体素光谱分析(SVS)和MR 光谱成像(MRSI)将并行发展。2H到1H MRS将能够量化和成像 在活体人脑中的浓度和代谢通量通过整个代谢途径 单次扫描。在这个项目的第一部分，我们将使用最先进的mr兼容传感器和校准 扫描以准确表征空间场的不均匀性并监控扫描仪和对象相关 在第二部分中，我们将开发和验证一种新的动态1H-SVS 10.5T的技术，重点是通过靶向最大化可重复检测的代谢物的范围 单个精确定义的大脑区域。在第三部分，我们将建立一个新的高度精确和稳健的 10.5T的动态1H-MRSI方法，这将权衡询问广泛代谢物的能力 因为它有能力在整个大脑中想象出其中的一些。在最后部分，我们将证明该方案的可行性。 10.5T和7T动态2H-to-1H MRS非侵入性测量活体人脑代谢 2H标记的葡萄糖，并估计实验和生理变异性。我们将比较以下几种方法的性能 我们用来进行氚代谢成像的新工具。该项目的成功完成将为该项目提供一个强有力的工具 用于神经科学和新陈代谢研究。