Turning back the clock on brain cell aging

逆转脑细胞衰老的时钟

• 批准号: IN180100005
• 负责人: A/Prof Phillippa Taberlay
• 金额: $ 32.61万
• 依托单位: University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Indigenous
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/IN180100005
• 关键词: Turning; back; clock; brain; cell

This proposal aims to determine the role of fundamental epigenetic mechanisms in the process of aging and whether modulation of the epi-genome underpins an improvement in cognitive function. It combines the fields of epigenetics, neurosciences and mathematics to delineate the dynamics of DNA methylation and histone modification marking on the transcriptome during normal, healthy aging. The outcomes will provide significant new knowledge of the variable cognitive decline that occurs in healthy aging and why some populations age less successfully than others do. Better understanding of the impact of environmental change on the biology of aging has potential community benefits.

该提案旨在确定基本表观遗传机制在衰老过程中的作用，以及表观基因组的调节是否支持认知功能的改善。它结合了表观遗传学，神经科学和数学领域，描绘了正常，健康衰老过程中转录组上DNA甲基化和组蛋白修饰标记的动态。这些结果将为健康老龄化中发生的可变认知衰退以及为什么一些人群的年龄比其他人更不成功提供重要的新知识。更好地了解环境变化对衰老生物学的影响具有潜在的社区利益。