NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing

基于 NMR 的快速流体评估：设备设计和信号处理

• 批准号: 10441674
• 负责人: Michael J Cima
• 金额: $ 58.18万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-05 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10441674
• 关键词: Affect; Algorithms; Blood Pressure; Body Weight decreased; Cardiovascular system; Cell Nucleus; Clinical; Clinical Research; Clinical Trials; Clinical assessments; Collaborations; Custom; Data; Dehydration; Development; Device Designs; Devices; Diagnostic; Dialysis patients; Dialysis procedure; Disease; End stage renal failure; Engineering; Excision; Exercise; Extracellular Fluid; Fluid Balance; Fluid Shifts; Fluid overload; Future; Goals; Headache; Health; Heart; Hemodialysis; Hour; Human; Hypovolemia; Individual; Institutes; Intramuscular; Kidney; Kidney Diseases; Laboratories; Leg; Liquid substance; Magnetic Resonance; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Methods; Moderate Exercise; Morbidity - disease rate; Muscle; Muscle Cramp; Nature; Noise; Organ; Outcome; Participant; Patients; Physicians; Physiologic pulse; Population; Quality of Care; Quality of life; Research; Resources; Scientist; Shapes; Side; Signal Transduction; Skeletal Muscle; Soldier; Subcutaneous Tissue; Surface; Target Populations; Technology; Therapeutic; Time; Tissues; Validation; Water; Work; associated symptom; base; clinical decision-making; clinically relevant; design; experience; improved; improved outcome; in vivo; magnetic field; mobile sensor; mortality; multidisciplinary; point of care; portability; radio frequency; response; sensor; signal processing; skeletal muscle differentiation; subcutaneous; tool

NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing PROJECT SUMMARY Our goal is to develop a portable, non-invasive, measurement of volume status to improve quality of life and reduce morbidity and mortality among hospitalized patients. Maintenance of euvolemic status and proper fluid balance are critical for health and improved outcomes for renal, cardiovascular, and many other disease types as well as in healthy populations prone to dehydration such as athletes and soldiers. Our laboratory has previously constructed a portable single sided magnetic resonance (MR) sensors that is capable of resolving individual fluid compartments (subcutaneous, intramuscular, etc.) within tissue. This sensor was used in a pilot clinical trial with end stage kidney disease patients. Quantitative MRI results on these patients demonstrated that the first sign of fluid overload among hemodialysis patients is an expanded skeletal muscle extracellular fluid (ECF) space. The early stage nature of the technology was evident in that study as the portable sensor could not unambiguously differentiate skeletal muscle tissue from subcutaneous tissue. The proposed research includes the design of a new portable low-field MR sensor and improved signal processing that will allow it to capture the same quantitative assessment of volume status currently achievable with quantitative MRI (qMRI). We measure local fluid distribution in the target in vivo tissue compartment. In the case of fluid volume status, our hypothesis is that a localized skeletal muscle measurement is representative of systemic fluid distribution based on results from a prior study1. The optimized sensor will have the sensitive region of the magnetic field designed to target the skeletal muscle. The existing and newly designed portable MR sensors will be used to measure intramuscular fluid distribution in end stage kidney disease patients undergoing dialysis treatment as well as in healthy athletes experiencing exercise induced fluid loss. The sensor measurement will allow for quantification of volume overload (hypervolemia) or depletion (hypovolemia) and allow for its use in clinical decision making. Dialysis patients and athletes are the target population for the following proposal. The rapid reduction in fluid volume during a dialysis session and exercise respectively provides the ideal clinical context for performing repeated fluid status measurements.

基于核磁共振的流体快速评价装置设计与信号处理 项目总结 我们的目标是开发一种便携式、非侵入性的容量状态测量方法，以提高质量 改善生活，减少住院病人的发病率和死亡率。维持等容血容量 状态和适当的液体平衡对肾脏的健康和改善预后至关重要， 心血管疾病和许多其他类型的疾病，以及容易患上 运动员和士兵等脱水。我们的实验室之前已经构建了一种便携式 能够分辨单个流体的单面磁共振(MR)传感器 间隔(皮下、肌肉内等)在组织内。该传感器在飞行员身上使用。 终末期肾病患者的临床试验。这些患者的定量MRI结果 证明血液透析患者液体超载的第一个症状是扩张 骨骼肌胞外液(ECF)间隙。这项技术的早期性质是 在这项研究中很明显，因为便携式传感器不能明确区分骨骼肌 皮下组织中的组织。 提出的研究包括设计一种新的便携式低场磁共振传感器和 改进的信号处理，使其能够捕获相同的定量评估 容量状态目前可通过定量磁共振成像(QMRI)获得。我们测量局部流体 分布于体内靶区组织间。在流体体积状态的情况下，我们的 假设局部骨骼肌测量是体液的代表。 基于先前研究结果的分布1。优化后的传感器将具有更高的灵敏度 以骨骼肌为目标的磁场区域。现有的和新的 设计的便携式磁共振传感器将用于在终末期测量肌肉内的液体分布 接受透析治疗的肾病患者以及健康运动员经历 运动引起的液体流失。传感器测量将允许对体积进行量化 超负荷(高容量血症)或衰竭(低容量血症)，并允许在临床决策中使用 制作。透析患者和运动员是以下提案的目标人群。这个 在透析期和运动期间迅速减少液体量分别提供 适用于重复进行液体状态测量的理想临床环境。