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NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing

基于 NMR 的快速流体评估：设备设计和信号处理

基本信息

批准号：
10617808
负责人：
Michael J Cima
金额：
$ 54.1万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-05 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10617808
关键词：
Affect Algorithms Blood Pressure Body Weight decreased Cardiovascular system Cell Nucleus Clinical Clinical Research Clinical Trials Clinical assessments Collaborations Custom Data Dehydration Development Device Designs Devices Diagnostic Dialysis patients Dialysis procedure Disease End stage renal failure Engineering Excision Exclusion Exercise Extracellular Fluid Fluid Balance Fluid Shifts Fluid overload Future Goals Headache Health Heart Hemodialysis Hospitalization Hour Human Hypovolemia Hypovolemics Individual Institution Intramuscular Kidney Kidney Diseases Laboratories Leg Liquid substance Magnetic Resonance Magnetic Resonance Imaging Maintenance Measurement Measures Methods Moderate Exercise Morbidity - disease rate Muscle Muscle Cramp Nature Noise Organ Outcome Participant Patients Physicians Physiologic pulse Population Quality of Care Quality of life Research Resources Scientist Shapes Side Signal Transduction Skeletal Muscle Soldier Subcutaneous Tissue Surface Target Populations Technology Therapeutic Time Tissues Validation Water Work associated symptom clinical decision-making clinically relevant design experience fabrication improved improved outcome in vivo magnetic field mobile sensor mortality multidisciplinary point of care portability radio frequency response sensor signal processing skeletal muscle differentiation subcutaneous tool

项目摘要

NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing PROJECT SUMMARY Our goal is to develop a portable, non-invasive, measurement of volume status to improve quality of life and reduce morbidity and mortality among hospitalized patients. Maintenance of euvolemic status and proper fluid balance are critical for health and improved outcomes for renal, cardiovascular, and many other disease types as well as in healthy populations prone to dehydration such as athletes and soldiers. Our laboratory has previously constructed a portable single sided magnetic resonance (MR) sensors that is capable of resolving individual fluid compartments (subcutaneous, intramuscular, etc.) within tissue. This sensor was used in a pilot clinical trial with end stage kidney disease patients. Quantitative MRI results on these patients demonstrated that the first sign of fluid overload among hemodialysis patients is an expanded skeletal muscle extracellular fluid (ECF) space. The early stage nature of the technology was evident in that study as the portable sensor could not unambiguously differentiate skeletal muscle tissue from subcutaneous tissue. The proposed research includes the design of a new portable low-field MR sensor and improved signal processing that will allow it to capture the same quantitative assessment of volume status currently achievable with quantitative MRI (qMRI). We measure local fluid distribution in the target in vivo tissue compartment. In the case of fluid volume status, our hypothesis is that a localized skeletal muscle measurement is representative of systemic fluid distribution based on results from a prior study1. The optimized sensor will have the sensitive region of the magnetic field designed to target the skeletal muscle. The existing and newly designed portable MR sensors will be used to measure intramuscular fluid distribution in end stage kidney disease patients undergoing dialysis treatment as well as in healthy athletes experiencing exercise induced fluid loss. The sensor measurement will allow for quantification of volume overload (hypervolemia) or depletion (hypovolemia) and allow for its use in clinical decision making. Dialysis patients and athletes are the target population for the following proposal. The rapid reduction in fluid volume during a dialysis session and exercise respectively provides the ideal clinical context for performing repeated fluid status measurements.

基于核磁共振的快速流体评估：设备设计和信号处理