Semantic integration of protein epitopes and functional features for infectious and autoimmune disease knowledge discovery
用于传染病和自身免疫性疾病知识发现的蛋白质表位和功能特征的语义整合
基本信息
- 批准号:10442059
- 负责人:
- 金额:$ 48.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-15 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAllergic DiseaseAmino Acid SequenceAnimal ModelAnimalsAntibodiesAntigensAreaAutoimmune DiseasesAutoimmunityAwarenessBase SequenceCatalogsClinicalCommunicable DiseasesCommunitiesConsumptionCross ReactionsDataDatabasesDetectionDiseaseDisease modelDistance LearningEducational workshopEnsureEnvironmentEpitopesFundingGenerationsGenetic VariationGoalsGrowthHomologous GeneHomologous ProteinHumanHuman GeneticsHypersensitivityImmuneImmune EvasionImmune responseImmune systemImmunologicsImmunologyInfectionInsulin-Dependent Diabetes MellitusKnowledgeKnowledge DiscoveryLinkLupusMapsMonitorMultiple SclerosisNational Institute of Allergy and Infectious DiseaseOntologyOrganismOrthologous GenePharmaceutical PreparationsPlayPost-Translational Protein ProcessingProteinsPublicationsResearchResearch PersonnelResource InformaticsResourcesRoleSamplingSemanticsSequence HomologsSiteT-Cell ReceptorT-Lymphocyte EpitopesTransplantationVariantVisualizationVisualization softwareWorkbasecommunity engagementcross reactivitydata exchangedata visualizationdruggable targetfightinggenetic varianthuman diseaseimprovedinformation displayinsightinterestknowledge graphmeetingsnonhuman primatenoveloutreachpathogenpreventprotein protein interactionsocial mediatooltranslational scientistusabilityweb site
项目摘要
PROJECT SUMMARY
Immune epitopes--the portions of an antigen that are recognized by antibodies and T-cell receptors--are key to
understanding healthy and abnormal immune responses. The Immune Epitope Database (IEDB) is a freely
available resource funded by the National Institute of Allergy and Infectious Diseases (NIAID) that catalogs
experimental data on more than one million antibody and T cell epitopes studied in humans, non-human
primates, and other animal species in the context of infectious disease, allergy, autoimmunity and
transplantation. As well, there is a wealth of information captured in other biomedical databases that could
potentially be applied to immunological research. The goal of this work is to integrate immune epitope
information from IEDB with the wealth of additional biomedical data in humans and model organisms, thereby
enabling novel opportunities for hypothesis generation and discovery. We will seamlessly connect epitopes to
the protein information in UniProtKB, which contains rich functional annotation and the means to display
protein sequence features, and the Protein Ontology (PRO), which provides orthology information and the
explicit representation of proteoforms. We will make further connections to resources specializing in protein
post-translational modifications (PTMs), protein-protein interactions, human genetic variation, diseases, and
drugs. Display of this information in the UniProt ProtVista environment and via the IEDB website will make it
easily accessible to the large community of immunology and disease researchers. Our work will enable novel
queries of high interest to translational researchers, such as: (1) What PTMs and/or genetic variants overlap
with an epitope of interest? Identification of such overlaps can provide insight into factors that affect
auto-antigenicity or immune evasion by pathogens; (2) Is a human epitope of interest found in
orthologous/homologous proteins in model organisms or vice-versa? This will allow researchers interested in
human disease to fully exploit knowledge derived from model organisms, and conversely, improve disease
models in non-human organisms. It will also enable identification of potential cross-reactivities within and
across organisms; and (3) Are there any druggable targets among the proteins that interact with autoantigenic
proteins associated with an autoimmune disease of interest? This work entails the following specific aims: (i)
Aim 1. Data exchange: Guided by use cases, we will connect epitopes within IEDB to data from PRO, UniProt,
and other informatics resources; (ii) Aim 2. Information access: Guided by user input, we will enhance
navigation, data visualization, and application interfaces at each resource and create connections between
them; and (iii) Aim 3. Community engagement: We will build community awareness of the connected resources
and ensure that the needs of stakeholders are reflected. This collaborative effort among multiple major
resources will overcome barriers to consumption of IEDB data, thereby supporting inquiry into the role of the
immune system in human disease.
项目总结
免疫表位--被抗体和T细胞受体识别的抗原部分--是关键
了解健康和异常的免疫反应。免疫表位数据库是一个免费的数据库
由国家过敏和传染病研究所(NIAID)资助的可用资源,该目录
在人类和非人类中研究的100多万个抗体和T细胞表位的实验数据
灵长类和其他动物物种在传染病、过敏、自身免疫和
移植。此外,在其他生物医学数据库中捕获的大量信息也可能
有可能应用于免疫学研究。这项工作的目标是整合免疫表位
来自IEDB的信息和丰富的人类和模型生物的额外生物医学数据,从而
为假说的产生和发现提供了新的机会。我们将把表位无缝连接到
UniProtKB中的蛋白质信息,包含丰富的功能标注和展示手段
蛋白质序列特征,以及蛋白质本体论(PRO),它提供正构学信息和
蛋白质形式的显式表示。我们将进一步连接到专门研究蛋白质的资源
翻译后修饰(PTM)、蛋白质-蛋白质相互作用、人类遗传变异、疾病和
毒品。在UniProt ProtVista环境中和通过IEDB网站显示这些信息将使
对于免疫学和疾病研究人员的大型社区来说,很容易获得。我们的工作将使小说
翻译研究人员非常感兴趣的问题,例如:(1)PTM和/或基因变体有哪些重叠
带着感兴趣的表位?识别这样的重叠可以提供对影响
自身抗原性或病原体的免疫逃避;(2)是人类感兴趣的表位,发现于
模式生物中的同源/同源蛋白质还是反之亦然?这将使研究人员对
人类疾病,充分利用来自模型生物的知识,反过来,改善疾病
在非人类生物体中的模型。它还将使识别潜在的交叉反应在和
跨生物体;以及(3)在与自身抗原相互作用的蛋白质中是否存在可用药的靶点
与感兴趣的自身免疫性疾病相关的蛋白质?这项工作的具体目标如下:(I)
目标1.数据交换:在用例的指导下,我们将IEDB中的表位与来自PRO、UniProt、
和其他信息学资源;(2)目标2.信息获取:以用户意见为导向,我们将加强
每个资源的导航、数据可视化和应用程序接口,并在
目标3.社区参与:我们将建立社区对相关资源的认识
并确保利益相关者的需求得到反映。多家主要企业之间的协作努力
资源将克服使用IEDB数据的障碍,从而支持对IEDB作用的调查
人类疾病中的免疫系统。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
DARREN A NATALE其他文献
DARREN A NATALE的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('DARREN A NATALE', 18)}}的其他基金
Semantic integration of protein epitopes and functional features for infectious and autoimmune disease knowledge discovery
用于传染病和自身免疫性疾病知识发现的蛋白质表位和功能特征的语义整合
- 批准号:
10596633 - 财政年份:2022
- 资助金额:
$ 48.14万 - 项目类别:
相似海外基金
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 48.14万 - 项目类别:
Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 48.14万 - 项目类别:
Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 48.14万 - 项目类别:
Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 48.14万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 48.14万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 48.14万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 48.14万 - 项目类别:
Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
- 批准号:
2301846 - 财政年份:2023
- 资助金额:
$ 48.14万 - 项目类别:
Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 48.14万 - 项目类别:
Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
- 批准号:
23K16076 - 财政年份:2023
- 资助金额:
$ 48.14万 - 项目类别:
Grant-in-Aid for Early-Career Scientists