Amazonian Center of Excellence in Malaria Research

亚马逊国际疟疾研究卓越中心的总体研究目标是 组织一种全面的方法，以了解亚马逊疟疾的生物学特征，以实现 区域控制和消灭恶性疟原虫和间日疟原虫的最终目标。而在过去 亚马孙ICEMR主要集中在间日疟原虫上，因为它在该地区的影响更大，因为最近 在巴西和秘鲁，恶性疟原虫的发展也将是我们工作的重点。年在国家一级 在巴西，国家疟疾控制计划已将恶性疟原虫作为消灭努力的主要重点，如P。 恶性疟疾仍然在巴西亚马孙西部的朱鲁河谷高度流行。在秘鲁，在 2010年停止全球基金支持的疟疾控制努力，恶性疟原虫重新成为 重要的公共卫生威胁。亚马孙ICEMR最近与洛雷托卫生部的会议 目睹了对这种重新出现的高度关切，以及该部对利用 亚马孙ICEMR的研究优势有助于解决这一紧急和及时的问题。总体而言，我们预计 吸取的经验教训将有助于实现全球根除疟疾的大胆目标。 亚马孙ICEMR在巴西和秘鲁有5个流行病学上不同的疟疾流行地点。项目1 专注于疟疾流行病学，并采用多学科方法研究不同的传播方式 使用社会人口学分析的巴西和秘鲁疟疾流行地点的模式，分子 流行病学和基因组学，以及整合ICEMR所有三个项目的数学建模，包括 项目2，重点是媒介生态学和传播生物学；项目3，重点是 无症状寄生虫血症的免疫学机制与临床免疫 临床免疫(无症状寄生虫血症)与非免疫(急性、有症状)的生物特征 疟疾)。我们的长期目标是开发新的淘汰策略的科学基础，使其成为 在亚马逊地区部署，可广泛推广到其他疟疾流行地区。这个拟建的中心 因此对秘鲁和巴西亚马逊地区的疟疾研究采取了全面的方法， 它将被用来通知巴西和秘鲁的卫生部以及泛美卫生组织的官员 组织和亚马逊疟疾倡议，制定消除疟疾的新办法 以科学数据为基础的政策。

The overall research aim of the Amazonian International Center of Excellence in Malaria Research is to organize a comprehensive approach to understanding the biological features of Amazonian malaria towards the ultimate goal of regional control and elimination of Plasmodium falciparum and P. vivax. While in the past the Amazonian ICEMR focused primarily on P. vivax because of its greater impact in the region, given recent developments in both Brazil and Peru, P. falciparum will also be a focus of our work. At the national level in Brazil, the national malaria control program has made P. falciparum a primary focus of elimination efforts, as P. falciparum malaria remains highly prevalent in the Juruá Valley in western Brazilian Amazonia. In Peru, after the cessation of Global Fund-supported malaria control efforts in 2010, P. falciparum has reemerged as an important public health threat. The Amazonian ICEMR's recent meetings with the Loreto Ministry of Health witnessed the high level of concern about this re-emergence and the Ministry's interest in harnessing the Amazonian ICEMR's research strengths to addressing this emergent and timely issue. Overall, we anticipate that the lessons learned will contribute towards the audacious goal of global malaria eradication. The Amazonian ICEMR has 5 epidemiologically distinct malaria-endemic sites in Brazil and Peru. Project 1 focuses on malaria epidemiology and takes multidisciplinary approaches to study distinct transmission patterns in the Brazilian and Peruvian malaria-endemic sites using socio-demographic analysis, molecular epidemiology and genomics, and mathematical modeling to integrate all three ICEMR Projects, including Project 2, which focuses on vector ecology and transmission biology, and Project 3, which focuses on immunological mechanisms of asymptomatic parasitemia and clinical immunity, and to discover biosignatures of clinically immune (asymptomatic parasitemia) vs non-immune (acute, symptomatic malaria). Our long-term goal is to develop the scientific underpinnings of novel elimination strategies to be deployed in Amazonia, with broad generalizability to other malaria-endemic regions. This proposed Center therefore takes on a comprehensive approach to malaria research in the Peruvian and Brazilian Amazon, which will be used to inform Ministries of Health in Brazil and Peru, and officials of the Pan American Health Organization and the Amazonian Malaria Initiative, of new approaches to develop malaria elimination policies based on scientific data.