Center for Point-of-Care Technologies Research for Sexually Transmitted Diseases

项目摘要 我们中心的长期目标包括解决美国的性病/艾滋病流行问题。 通过开发和更好地使用床旁（POC）测试， 以解决健康不平等问题，改善个人的性健康。我们的具体目标 是：1.建立一个“床旁护理开发和测试卓越中心 性传播疾病（STD）的POCT测试”的核心，可以： 通过协作努力开发和应用护理点技术， 科学和技术能力与临床需要和开发人员的培训，以及 作为POCT的最终用户。2.使用技术进步的临床驱动因素来开发和 扩大现有的POC STD技术，通过提供援助和反馈， 以“go-no go”方式向开发人员提供迭代方式，这样我们就可以确保 每个项目都得到满足。3.实现可顺利协同工作的功能核心组件 以合作的方式，并与其他成员的即时技术研究 网络（POCTRN），它可以与我们的管理组件一起实现一个 从开发原型试验到早期试验， 在这种协调一致的方式下，我们可以帮助 随着POC检测的逻辑发展，证明具有足够的资格， 科学价值，并可以朝着最终FDA提交和商业化的方向发展。 这些目标和目的将由一个有效的行政部门来实现， 确定POC用户的需求，培训科学家，资助科学家和工程师， 开发原型和成熟的POC技术，并进行试点测试和实施 POC测试在不同的临床环境，这将导致商业化和使用 POC测试用于诊断性病，以改善美国个人的性健康 国家和世界其他地区。

Project Summary The long-term goals of our center include addressing the epidemics of STDs/HIV in the U.S. and in resource-poor settings by development and better use of Point-of-Care (POC) tests, so as to address health inequity and improve the sexual health of individuals. Our specific aims are: 1. To develop a “Center of Excellence for the Development and Testing of Point of Care Tests (POCT) for Sexually Transmitted Diseases (STDs)” with cores that can: drive the development and application of point-of-care technologies via collaborative efforts that merge scientific and technological capabilities with clinical need and training of developers, as well as end users of POCT. 2. To use clinical drivers of technology progression for developing and expanding existing POC STD technologies, by providing assistance and feed back in an iterative fashion to developers in a “go-no go” manner, such that we insure that deliverables for each project are met. 3. To implement functioning core components that work smoothly together in a collaborative fashion and with other members of the Point-of-Care Technologies Research Network (POCTRN), which can work with our administrative component to implement a smooth transition along a pipeline from developmental prototype assays through early in- house, clinical translation and validation testing, In this coordinated manner, we can assist with the logical development of POC assays, which prove to have qualifications of sufficient scientific merit and can progress towards eventual FDA submission and commercialization. These goals and aims will be accomplished by an effective administrative component, ascertaining needs of users of POC, training of scientists, funding scientists and engineers for development of prototype and mature POC technologies, and pilot testing and implementation of POC tests in diverse clinical settings, which will lead to the commercialization and use of POC tests for diagnosing STDs in order to improve the sexual health of individuals in the United States and the rest of the world.