Supporting RADx Technology Development: Leveraging International Networks and Clinical Context

项目总结 新冠肺炎大流行正在美国经历新一轮感染浪潮，原因是新的、高度传染性的 令人担忧的变种和减弱的疫苗免疫力。很明显，需要更多、更快速的诊断测试。在这 提案，我们将在约翰·霍普金斯大学POC性技术研究中心的成功基础上再接再厉 传播疾病已被用来支持诊断技术的快速加速 程序。在这项补充拨款建议中，我们有4个目标：1)增加国际新冠肺炎临床 年传染病研究所的诊断测试和生物信息库开发研究网站 坎帕拉与我们合作了两个周期的POCTRN资金的团队，以及在哪里 疫苗接种率低，感染浪潮仍在持续；2)继续召集高度 成功的RADx Tech Wave 2临床评审委员会和Add on Desktop体外评估 设备；3)使用下一代测序和微阵列来监测变异和其他呼吸道 导致流感样疾病的病原体；以及4)为需要帮助的特定公司提供支持 技术开发专门知识和生物武器，以加快发展。

PROJECT SUMMARY The COVID-19 pandemic is undergoing a new wave of infections in the US fueled by new, highly transmissible variants of concern and waning vaccine immunity. The need for more, rapid diagnostic tests is clear. In this proposal, we will build on the success of the Johns Hopkins POC Technologies Research Center for Sexually Transmitted Diseases which has been leveraged to support the Rapid Acceleration of Diagnostics Technology Program. In this supplemental grant proposal, we have 4 aims: 1) to add an international COVID-19 clinical research site for diagnostic testing and biorepository development at the Infectious Diseases Institute in Kampala with the team with whom we have been collaborating for 2 cycles of POCTRN funding and where vaccination rates are low and there are on-going waves of infection; 2) to continue to convene the highly successful Clinical Review Committee for RADx Tech Wave 2 and add on desktop evaluations of in vitro devices; 3) to use next generation sequencing and microarrays to monitor variants and other respiratory pathogens that cause influenza-like illness; and 4) to provide support for specific companies needing technology development expertise and biospecimens to accelerate development.