Pediatric Endocrine Fellowship Training in Diabetes and Endocrine Research

摘要 为了解决学术儿科内分泌学家的严重短缺，该培训计划将 利用重要的新机遇推进糖尿病和内分泌研究 人类基因组计划等最新科学进展， 移植和生物力学和生物工程胰岛，以及NIH路线图 将GCRC项目从面向患者的研究转变为临床转化 科学奖。该计划将支持学员在长达2年的研究培训， 奖学金水平。培训教师包括来自儿童的26名科学导师 医院和宾夕法尼亚大学佩雷尔曼医学院， 优秀的证书和积极资助的研究计划和完善的培训 记录这些导师将指导学员进行基础实验室研究和/或患者- 与糖尿病和内分泌失调相关的定向和转化研究项目， 孩子研究机会将包括几个基础研究领域（细胞功能， 激素作用、疾病机制、内分泌生理学和转录 条例）。以患者为导向的研究机会将包括转化研究，疾病 机制，病理生理学，糖尿病并发症，遗传学，临床试验，代谢 综合征、营养与流行病学。该计划包括学员的多种互动 基础和临床研究以及研究各方面的培训，包括生物统计学， 生物伦理学，分子生物学等。该计划得到了强大的支持， 儿童医院和宾夕法尼亚大学的机构资源，包括 CTSA和宾夕法尼亚大学DERC。请求支持3个同伴插槽 在这个项目中，每年。本次T32培训计划更新的长期目标是开发 新一代的儿科内分泌学家，他们将有能力进行创新和 科学严谨的以病人为导向和以实验室为基础的糖尿病和内分泌研究 儿童疾病。

ABSTRACT To address the severe shortage of academic pediatric endocrinologists, this Training Program will take advantage of the important new opportunities for advancing diabetes and endocrine research in children provided by such recent scientific advances as the Human Genome Project, islet transplantation and biomechanical and bio-engineered islets, and the NIH roadmap transformation of GCRC programs for patient- oriented research into Clinical Translational Science Awards. The Program will support Trainees during up to 2 years of research training at the fellowship level. The Training faculty includes 26 scientific mentors from the Children’s Hospital and the Perelman School of Medicine at University of Pennsylvania who have outstanding credentials and active funded research programs and well-established training records. These mentors will supervise Trainees in basic laboratory research and/or patient- oriented and translational research projects related to diabetes and endocrine disorders in children. Research opportunities will include several areas of basic research (ß-Cell Function, Hormone Action, Mechanisms of Disease, Endocrine Physiology, and Transcriptional Regulation). Patient-oriented research opportunities will include Translational Research, Disease Mechanisms, Pathophysiology, Diabetes Complications, Genetics, Clinical Trials, Metabolic Syndrome, Nutrition, and Epidemiology. The Program includes multiple interactions for Trainees with basic and clinical research and training in all aspects of research, including biostatistics, bioethics, molecular biology, etc. The Program is strongly supported by access to a superb range of institutional resources at Children’s Hospital and University of Pennsylvania, including the CTSA and the University of Pennsylvania DERC. The request is made to support 3 fellow slots in this Program each year. The long-term goal of this T32 Training Program renewal is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative and scientifically rigorous patient- oriented and laboratory-based research in diabetes and endocrine disorders of children.