Pediatric Endocrine Fellowship Training in Diabetes and Endocrine Research

摘要 为了解决学术儿科内分泌科医生的严重短缺问题，本培训计划将 抓住推进糖尿病和内分泌研究的重要新机遇 由人类基因组计划、胰岛等最新科学进步提供的儿童 移植、生物力学和生物工程胰岛，以及美国国立卫生研究院路线图 将以患者为中心的GCRC项目转化为临床转化项目 科学奖。该计划将在长达2年的研究性培训期间为学员提供支持 团契级别。培训人员包括来自儿童基金会的26名科学导师 医院和宾夕法尼亚大学佩雷尔曼医学院 优秀的资历和积极资助的研究项目以及完善的培训 唱片。这些导师将指导基础实验室研究和/或患者的受训人员- 年与糖尿病和内分泌疾病相关的定向和转化性研究项目 孩子们。研究机会将包括基础研究的几个领域(？细胞功能， 激素作用、疾病机制、内分泌生理学和转录 条例)。以患者为中心的研究机会将包括转化研究、疾病 机制，病理生理学，糖尿病并发症，遗传学，临床试验，代谢 综合征、营养学和流行病学。该计划包括为受训人员提供的多种互动 通过基础和临床研究以及包括生物统计学在内的所有研究方面的培训， 生物伦理学、分子生物学等。该计划得到了极高范围的访问的大力支持 儿童医院和宾夕法尼亚大学的机构资源，包括 CTSA和宾夕法尼亚大学DERC。该请求是为了支持3个伙伴插槽 每年在这个项目中。此次T32培训计划更新的长期目标是开发 新一代儿科内分泌学家将有能力进行创新和 科学严谨、以病人为中心、以实验室为基础的糖尿病和内分泌研究 儿童精神障碍。

ABSTRACT To address the severe shortage of academic pediatric endocrinologists, this Training Program will take advantage of the important new opportunities for advancing diabetes and endocrine research in children provided by such recent scientific advances as the Human Genome Project, islet transplantation and biomechanical and bio-engineered islets, and the NIH roadmap transformation of GCRC programs for patient- oriented research into Clinical Translational Science Awards. The Program will support Trainees during up to 2 years of research training at the fellowship level. The Training faculty includes 26 scientific mentors from the Children’s Hospital and the Perelman School of Medicine at University of Pennsylvania who have outstanding credentials and active funded research programs and well-established training records. These mentors will supervise Trainees in basic laboratory research and/or patient- oriented and translational research projects related to diabetes and endocrine disorders in children. Research opportunities will include several areas of basic research (ß-Cell Function, Hormone Action, Mechanisms of Disease, Endocrine Physiology, and Transcriptional Regulation). Patient-oriented research opportunities will include Translational Research, Disease Mechanisms, Pathophysiology, Diabetes Complications, Genetics, Clinical Trials, Metabolic Syndrome, Nutrition, and Epidemiology. The Program includes multiple interactions for Trainees with basic and clinical research and training in all aspects of research, including biostatistics, bioethics, molecular biology, etc. The Program is strongly supported by access to a superb range of institutional resources at Children’s Hospital and University of Pennsylvania, including the CTSA and the University of Pennsylvania DERC. The request is made to support 3 fellow slots in this Program each year. The long-term goal of this T32 Training Program renewal is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative and scientifically rigorous patient- oriented and laboratory-based research in diabetes and endocrine disorders of children.