Pediatric Endocrine Fellowship Training in Diabetes and Endocrine Research

T32的摘要 描述：为了解决学术儿科内分泌学家的严重短缺，本培训计划 将利用重要的新机遇，推进糖尿病和内分泌研究， 人类基因组计划、胰岛移植和 生物力学和生物工程胰岛，以及GCRC项目的NIH路线图转换， 临床转化科学奖（Clinical Translational Science Awards）该计划将在最多 2年研究金一级的研究培训。培训教师包括29名科学导师， 儿童医院和宾夕法尼亚大学医学院， 优秀的证书和积极资助的研究计划和良好的培训记录。这些 导师将指导学员进行基础实验室研究和/或以患者为导向的翻译 与儿童糖尿病和内分泌失调有关的研究项目。研究机会将 包括几个基础研究领域（ss细胞功能，激素作用，疾病机制， 内分泌生理学和转录调节）。面向患者的研究机会将包括 转化研究，疾病机制，病理生理学，糖尿病并发症，遗传学，临床 试验、代谢综合征、营养学和流行病学。该计划包括多种互动， 接受基础和临床研究以及包括生物统计学在内的各方面研究培训的学员， 生物伦理学，分子生物学等。该计划得到了广泛的支持， 儿童医院和宾夕法尼亚大学的机构资源，包括CTSA和 宾夕法尼亚大学DERC。该请求是为了支持3个研究员插槽和2个学生插槽在这个 每年的节目。此次T32培训计划更新的长期目标是开发新一代 儿科内分泌学家谁将配备进行创新和科学严谨的病人- 在儿童糖尿病和内分泌失调方面进行以实验室为基础的研究。

ABSTRACT for T32 DESCRIPTION: To address the severe shortage of academic pediatric endocrinologists, this Training Program will take advantage of the important new opportunities for advancing diabetes and endocrine research in children provided by such recent scientific advances as the Human Genome Project, islet transplantation and biomechanical and bio-engineered islets, and the NIH roadmap transformation of GCRC programs for patient- oriented research into Clinical Translational Science Awards. The Program will support Trainees during up to 2 years of research training at the fellowship level. The Training faculty includes 29 scientific mentors from the Children's Hospital and the P e r e l m a n S c h o o l o f M e d i c i n e a t University of Pennsylvania who have outstanding credentials and active funded research programs and well-established training records. These mentors will supervise Trainees in basic laboratory research and/or patient-oriented and translational research projects related to diabetes and endocrine disorders in children. Research opportunities will include several areas of basic research (ss-Cell Function, Hormone Action, Mechanisms of Disease, Endocrine Physiology, and Transcriptional Regulation). Patient-oriented research opportunities will include Translational Research, Disease Mechanisms, Pathophysiology, Diabetes Complications, Genetics, Clinical Trials, Metabolic Syndrome, Nutrition, and Epidemiology. The Program includes multiple interactions for Trainees with basic and clinical research and training in all aspects of research, including biostatistics, bioethics, molecular biology, etc. The Program is strongly supported by access to a superb range of institutional resources at Children's Hospital and University of Pennsylvania, including the CTSA and the University of Pennsylvania DERC. The request is made to support 3 fellow slots and 2 student slots in this Program each year. The long-term goal of this T32 Training Program renewal is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative and scientifically rigorous patient- oriented and laboratory-based research in diabetes and endocrine disorders of children.