Pediatric Endocrine Fellowship Training in Diabetes and Endocrine Research

描述(申请人提供)：为了解决学术儿科内分泌学家的严重短缺，本培训计划将利用人类基因组计划、胰岛移植、生物力学和生物工程胰岛等最新科学进展为推进儿童糖尿病和内分泌研究提供的重要新机遇，以及NIH将GCRC面向患者的研究计划转变为临床翻译科学奖的路线图。该计划将在研究金层面为学员提供长达两年的研究培训。培训人员包括来自儿童医院和宾夕法尼亚大学佩雷尔曼医学院的29名科学导师，他们拥有出色的资历、积极资助的研究项目和良好的培训记录。这些导师将指导与儿童糖尿病和内分泌紊乱有关的基础实验室研究和/或以患者为导向的转化性研究项目的受训人员。研究机会将包括基础研究的几个领域(细胞功能、激素作用、疾病机制、内分泌生理学和转录调控)。面向患者的研究机会将包括转化研究、疾病机制、病理生理学、糖尿病并发症、遗传学、临床试验、新陈代谢综合征、营养学和流行病学。该计划包括为学员提供与基础和临床研究的多重互动，并在研究的各个方面进行培训，包括生物统计学、生物伦理学、分子生物学等。该计划得到了儿童医院和宾夕法尼亚大学一系列极好的机构资源的大力支持，包括CTSA和宾夕法尼亚大学DERC。该申请是为了每年支持本计划的3个同学名额和2个学生名额。此次T32培训计划更新的长期目标是培养新一代儿科内分泌学家，他们将具备在儿童糖尿病和内分泌疾病方面开展创新和科学严谨的以患者为导向和以实验室为基础的研究的能力。

DESCRIPTION (provided by applicant):To address the severe shortage of academic pediatric endocrinologists, this Training Program will take advantage of the important new opportunities for advancing diabetes and endocrine research in children provided by such recent scientific advances as the Human Genome Project, islet transplantation and biomechanical and bio-engineered islets, and the NIH roadmap transformation of GCRC programs for patient- oriented research into Clinical Translational Science Awards. The Program will support Trainees during up to 2 years of research training at the fellowship level. The Training faculty includes 29 scientific mentors from the Children's Hospital and the Perelman School of Medicine at the University of Pennsylvania who have outstanding credentials and active funded research programs and well-established training records. These mentors will supervise Trainees in basic laboratory research and/or patient-oriented and translational research projects related to diabetes and endocrine disorders in children. Research opportunities will include several areas of basic research (Cell Function, Hormone Action, Mechanisms of Disease, Endocrine Physiology, and Transcriptional Regulation). Patient-oriented research opportunities will include Translational Research, Disease Mechanisms, Pathophysiology, Diabetes Complications, Genetics, Clinical Trials, Metabolic Syndrome, Nutrition, and Epidemiology. The Program includes multiple interactions for Trainees with basic and clinical research and training in all aspects of research, including biostatistics, bioethics, molecular biology, etc. The Program is strongly supported by access to a superb range of institutional resources at Children's Hospital and University of Pennsylvania, including the CTSA and the University of Pennsylvania DERC. The request is made to support 3 fellow slots and 2 student slots in this Program each year. The long-term goal of this T32 Training Program renewal is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative and scientifically rigorous patient- oriented and laboratory-based research in diabetes and endocrine disorders of children.