Improved Detection of Cerebral Metastases using a using a Novel T1 Relaxation-Enhanced Steady-State (T1RESS) MRI Technique
使用新型 T1 弛豫增强稳态 (T1RESS) MRI 技术改进脑转移瘤的检测
基本信息
- 批准号:10440636
- 负责人:
- 金额:$ 53.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-12 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAnatomyAppearanceApplications GrantsBiological ProductsBloodBlood - brain barrier anatomyBlood VesselsBrainBrain NeoplasmsCerebrumClinicalContrast MediaDepositionDetectionDiseaseDoseEnhancing LesionEquationFatty acid glycerol estersFrequenciesGadoliniumGoalsImageImaging TechniquesInstitutionLesionMagnetic Resonance ImagingMetastatic malignant neoplasm to brainMethodsModelingMorphologic artifactsNeckNeoplasm MetastasisNephrogenic Systemic FibrosisNoiseOcular orbitPatientsPhasePhysiologic pulsePilot ProjectsPositron-Emission TomographyPrognosisPublishingRadiosurgeryRelaxationResearchResolutionScanningScienceSensitivity and SpecificitySignal TransductionSiteSpecificityTechniquesTimeTissuesVariantWaterbasebrain magnetic resonance imagingbrain tumor imagingcancer imagingcontrast enhancedcostdiagnostic accuracydosagehealthy volunteerimprovedneuroimagingnovelrisk minimizationskull basestandard of caretreatment planningtumortumor diagnosis
项目摘要
Contrast-enhanced magnetic resonance imaging (MRI) is the cornerstone for brain tumor diagnosis and
treatment planning. While its sensitivity for metastases is superior to that of CT or PET-CT, small lesions (<5-
mm) and leptomeningeal spread may still be missed, which can have a major impact on prognosis and
planning for stereotactic radiosurgery, as well as on the use of targeted biologics that cross the blood-brain
barrier. A method that could further improve the sensitivity and specificity of MRI for brain tumors would be of
great clinical benefit. Towards this end, we have developed a new class of pulse sequences, called T1
Relaxation-Enhanced Steady-State (T1RESS), that greatly improves the visibility of tumors in contrast-
enhanced MRI. Compared with existing neuroimaging techniques, T1RESS at least doubles the tumor-to-
background contrast while significantly improving the tumor-to-background contrast-to-noise ratio. An
“unbalanced” version (uT1RESS) renders blood vessel dark and is the focus of our proposal.
In a preliminary study of 54 adult patients that was published in Science Advances, uT1RESS provided
a remarkable twofold or greater improvement in tumor-to-brain contrast along with a marked improvement in
lesion-to-brain contrast-to-noise in comparison to standard-of-care MPRAGE and other pulse sequences that
are commonly used to image brain tumors. We found that even small metastatic tumor deposits and
leptomeningeal lesions that were difficult to distinguish from small blood vessels with standard imaging
techniques could be unambiguously identified.
The primary hypothesis of this five-year grant proposal is that T1RESS will significantly improve the
sensitivity for small brain metastases compared with existing MRI pulse sequences, while also reducing scan
times. A secondary hypothesis is that the twofold improvement in tumor-to-brain contrast obtained with
uT1RESS can be used to enable a substantial twofold reduction in gadolinium-based contrast agent (GBCA)
dosage. Studies of phantoms, healthy volunteers, and patients with brain tumors along with Bloch equation
modeling will be used to guide sequence optimization. These optimization efforts will be followed by a two-
institution study to determine the accuracy of the technique. Our specific aims are as follows:
1. To apply uT1RESS in healthy subjects and patients with brain tumors to systematically evaluate the impact
of various sequence parameters on image appearance, contrast, SNR, and lesion sharpness, and to optimize
the technique to maximize tumor visibility while minimizing scan time and image artifacts.
2. To perform a pilot study to determine whether metrics of tumor visibility using uT1RESS and a twofold
reduced GBCA contrast agent dosage are noninferior to MPRAGE with a standard contrast agent dosage.
3. To perform a two-site research trial at 3T to characterize the appearance of brain metastases with
uT1RESS, and to determine its accuracy for small brain metastases compared to standard-of-care MPRAGE.
对比增强磁共振成像(MRI)是脑肿瘤诊断和诊断的基础
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert R. Edelman其他文献
Prospective comparison of brain tumor detection and characterization using post-contrast Dixon uT1RESS and MPRAGE at 3 Tesla
在 3 特斯拉下使用对比后 Dixon uT1RESS 和 MPRAGE 对脑肿瘤检测和特征描述的前瞻性比较
- DOI:
10.1016/j.ejrad.2025.112283 - 发表时间:
2025-10-01 - 期刊:
- 影响因子:3.300
- 作者:
Adrienn Tóth;Robert R. Edelman;Muhammad Taha Hagar;Dmitrij Kravchenko;Milán Vecsey-Nagy;James Ira Griggers;Jonathan Eernisse;Tilman Emrich;M. Vittoria Spampinato;Akos Varga-Szemes - 通讯作者:
Akos Varga-Szemes
Breath-hold, whole-chest, equilibrium phase contrast-enhanced MR angiography using highly accelerated nonselective balanced T1 relaxation-enhanced steady-state (bT1RESS)
屏气全胸平衡稳态进动快速成像增强磁共振血管造影
- DOI:
10.1016/j.jocmr.2024.101615 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:6.100
- 作者:
Robert R. Edelman;Amit Pursnani;Nondas Leloudas;Ioannis Koktzoglou - 通讯作者:
Ioannis Koktzoglou
Acute diarrheal infections in infants I. Bacterial and viral causes.
婴儿急性腹泻感染 I. 细菌和病毒原因。
- DOI:
- 发表时间:
1980 - 期刊:
- 影响因子:0
- 作者:
Robert R. Edelman;Myron M. Levine - 通讯作者:
Myron M. Levine
The epidemiology of acquired immunodeficiency syndrome among heterosexuals.
异性恋者中获得性免疫缺陷综合征的流行病学。
- DOI:
10.1001/jama.1988.03410130130038 - 发表时间:
1988 - 期刊:
- 影响因子:0
- 作者:
Harry W. Haverkos;Robert R. Edelman - 通讯作者:
Robert R. Edelman
A comprehensive evaluation of the left atrium using cardiovascular magnetic resonance
使用心血管磁共振对左心房进行综合评估
- DOI:
10.1016/j.jocmr.2025.101852 - 发表时间:
2025-06-01 - 期刊:
- 影响因子:6.100
- 作者:
Maurice Pradella;Mohammed S.M. Elbaz;Daniel C. Lee;KyungPyo Hong;Rod S. Passman;Eugene Kholmovski;Dana C. Peters;Justin J. Baraboo;Daniel A. Herzka;Reza Nezafat;Robert R. Edelman;Daniel Kim - 通讯作者:
Daniel Kim
Robert R. Edelman的其他文献
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{{ truncateString('Robert R. Edelman', 18)}}的其他基金
Twofold Reduction in Gadolinium Dose for Brain MRI Exams using a Novel Unbalanced T1 Relaxation-Enhanced Steady-State (uT1RESS) Technique
使用新型不平衡 T1 弛豫增强稳态 (uT1RESS) 技术将脑 MRI 检查的钆剂量减少两倍
- 批准号:
10507378 - 财政年份:2022
- 资助金额:
$ 53.11万 - 项目类别:
Twofold Reduction in Gadolinium Dose for Brain MRI Exams using a Novel Unbalanced T1 Relaxation-Enhanced Steady-State (uT1RESS) Technique
使用新型不平衡 T1 弛豫增强稳态 (uT1RESS) 技术将脑 MRI 检查的钆剂量减少两倍
- 批准号:
10671616 - 财政年份:2022
- 资助金额:
$ 53.11万 - 项目类别:
Improved Detection of Cerebral Metastases using a using a Novel T1 Relaxation-Enhanced Steady-State (T1RESS) MRI Technique
使用新型 T1 弛豫增强稳态 (T1RESS) MRI 技术改进脑转移瘤的检测
- 批准号:
10609032 - 财政年份:2022
- 资助金额:
$ 53.11万 - 项目类别:
Nonenhanced 3T QISS MR Angiography of the Peripheral Arteries
非增强 3T QISS MR 外周动脉血管造影
- 批准号:
9324355 - 财政年份:2015
- 资助金额:
$ 53.11万 - 项目类别:
Nonenhanced 3T QISS MR Angiography of the Peripheral Arteries
非增强 3T QISS MR 外周动脉血管造影
- 批准号:
9766368 - 财政年份:2015
- 资助金额:
$ 53.11万 - 项目类别:
Non-Contrast Magnetic Resonance Angiography of Peripheral Vascular Disease
周围血管疾病的非对比磁共振血管造影
- 批准号:
8402153 - 财政年份:2010
- 资助金额:
$ 53.11万 - 项目类别:
Non-Contrast Magnetic Resonance Angiography of Peripheral Vascular Disease
周围血管疾病的非对比磁共振血管造影
- 批准号:
8034741 - 财政年份:2010
- 资助金额:
$ 53.11万 - 项目类别:
Non-Contrast Magnetic Resonance Angiography of Peripheral Vascular Disease
周围血管疾病的非对比磁共振血管造影
- 批准号:
8206849 - 财政年份:2010
- 资助金额:
$ 53.11万 - 项目类别:
Non-Contrast Magnetic Resonance Angiography of Peripheral Vascular Disease
周围血管疾病的非对比磁共振血管造影
- 批准号:
7786580 - 财政年份:2010
- 资助金额:
$ 53.11万 - 项目类别:
MR-Guided Endovascular Intervention Using Off-Resonance Contrast Angiography
使用非共振造影血管造影的 MR 引导血管内干预
- 批准号:
7588560 - 财政年份:2009
- 资助金额:
$ 53.11万 - 项目类别:
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