Nonenhanced 3T QISS MR Angiography of the Peripheral Arteries

非增强 3T QISS MR 外周动脉血管造影

基本信息

  • 批准号:
    9324355
  • 负责人:
  • 金额:
    $ 38.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-09-01 至 2020-08-31
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Peripheral arterial disease (PAD) is a potentially debilitating manifestation of systemic atherosclerosis affecting more than 200 million people worldwide. Accurate diagnosis is important for managing the disease and confers useful prognostic information. CT angiography (CTA) has become the preferred modality of vascular surgeons for the imaging evaluation of PAD, because of its simplicity and widespread availability. However, in addition to unwanted x-ray exposure from CTA, there is a nearly 40% prevalence of impaired renal function in patients with PAD. In such patients, iodine-based CT contrast agents pose a risk for contrast-induced nephropathy. As a result of efforts previously funded under NIH 1R01HL096916, the QISS nonenhanced MRA (NEMRA) technique was developed as a safer, simple "push button" nonenhanced alternative to CTA and contrast- enhanced MRA (CEMRA). However, no NEMRA technique has yet proven effective at 3 Tesla, which is widely considered the optimal field strength for CEMRA. In order to take advantage of the large signal-to-noise boost at 3 Tesla, severe image quality limitations relating to high specific absorption rate (SAR) and worsened B1 field homogeneity need to be overcome. This project aims to solve these challenges. It will improve patient outcomes by providing optimal selection of interventional treatment strategies irrespective of patient age, presence of diabetes, arrhythmia, metallic implants, or renal functional impairment. Moreover, it will greatly improve the safety profile of the imaging examination and avoid the need for renal function testing. This five-year project consists of an initial two-year technical development and optimization phase, followed by a two-site research study that will validate and ascertain the relative utility of 3T QISS MRA and peripheral CTA for the diagnosis and interventional management of PAD. Our specific aims are as follows: 1. To develop QISS techniques that are insensitive to magnetic susceptibility artifacts and B1 field inhomogeneity, and are optimized for the higher specific absorption rates encountered at 3 Tesla. These techniques will be evaluated in realistic flow phantoms, healthy subjects and patients with PAD. 2. To reduce the scan time for a complete QISS peripheral arterial study to less than five minutes so as to optimize procedural efficiency and patient comfort, while maintaining image quality and accuracy. 3. To develop ungated QISS techniques which match the image quality of ECG-gated QISS MRA. 4. To compare the diagnostic accuracy of QISS MRA at 3 Tesla (using techniques developed in Aims 1 and 2) for PAD compared with CTA, using digital subtraction angiography as the reference standard. A subsidiary aim is to compare UnQISS (developed in Aim 3) with CTA in patients with atrial fibrillation.
 描述(由申请人提供):外周动脉疾病(PAD)是一种全身性动脉粥样硬化的潜在衰弱表现,影响全球2亿多人。准确的诊断对于管理疾病和提供有用的预后信息是重要的。CT血管造影术(CTA)因其简单和广泛的可用性,已成为血管外科医生对PAD进行影像学评价的首选方式。然而,除了CTA不必要的X射线暴露外,PAD患者肾功能受损的患病率接近40%。在这类患者中,碘基CT造影剂存在造影剂肾病风险。作为先前在NIH 1R01HL 096916项下资助的努力的结果,QISS非增强MRA(NEMRA)技术被开发为CTA和对比增强MRA(CEMRA)的更安全、简单的“按钮”非增强替代技术。然而,还没有NEMRA技术被证明在3特斯拉下有效,这被广泛认为是CEMRA的最佳场强。为了利用3特斯拉时的大信噪比提升,需要克服与高比吸收率(SAR)和恶化的B1场均匀性相关的严重图像质量限制。该项目旨在解决这些挑战。它将通过提供介入治疗策略的最佳选择来改善患者结局,而不考虑患者年龄、糖尿病的存在, 心律失常、金属植入物或肾功能损害。此外,它将大大提高影像学检查的安全性,并避免肾功能检查的需要。这个为期五年的项目包括最初的两年技术开发和优化阶段,随后是一项两个地点的研究,该研究将验证和确定3T QISS MRA和外周CTA在PAD诊断和介入治疗中的相对效用。我们的具体目标如下:1.开发对磁化率伪影和B1场不均匀性不敏感的QISS技术,并针对3特斯拉下遇到的更高比吸收率进行优化。这些技术将在真实的血流模型、健康受试者和PAD患者中进行评价。2.将完整QISS外周动脉研究的扫描时间缩短至5分钟以内,以优化手术效率和患者舒适度,同时保持图像质量和准确性。3.开发与ECG门控QISS MRA图像质量匹配的非门控QISS技术。4.使用数字减影血管造影术作为参考标准,比较QISS MRA在3 T(使用目标1和2中开发的技术)与CTA对PAD的诊断准确性。另一个目的是在房颤患者中比较UnQISS(在目标3中开发)与CTA。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Robert R. Edelman其他文献

Prospective comparison of brain tumor detection and characterization using post-contrast Dixon uT1RESS and MPRAGE at 3 Tesla
在 3 特斯拉下使用对比后 Dixon uT1RESS 和 MPRAGE 对脑肿瘤检测和特征描述的前瞻性比较
  • DOI:
    10.1016/j.ejrad.2025.112283
  • 发表时间:
    2025-10-01
  • 期刊:
  • 影响因子:
    3.300
  • 作者:
    Adrienn Tóth;Robert R. Edelman;Muhammad Taha Hagar;Dmitrij Kravchenko;Milán Vecsey-Nagy;James Ira Griggers;Jonathan Eernisse;Tilman Emrich;M. Vittoria Spampinato;Akos Varga-Szemes
  • 通讯作者:
    Akos Varga-Szemes
Breath-hold, whole-chest, equilibrium phase contrast-enhanced MR angiography using highly accelerated nonselective balanced T1 relaxation-enhanced steady-state (bT1RESS)
屏气全胸平衡稳态进动快速成像增强磁共振血管造影
  • DOI:
    10.1016/j.jocmr.2024.101615
  • 发表时间:
    2025-03-01
  • 期刊:
  • 影响因子:
    6.100
  • 作者:
    Robert R. Edelman;Amit Pursnani;Nondas Leloudas;Ioannis Koktzoglou
  • 通讯作者:
    Ioannis Koktzoglou
Acute diarrheal infections in infants I. Bacterial and viral causes.
婴儿急性腹泻感染 I. 细菌和病毒原因。
  • DOI:
  • 发表时间:
    1980
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Robert R. Edelman;Myron M. Levine
  • 通讯作者:
    Myron M. Levine
The epidemiology of acquired immunodeficiency syndrome among heterosexuals.
异性恋者中获得性免疫缺陷综合征的流行病学。
  • DOI:
    10.1001/jama.1988.03410130130038
  • 发表时间:
    1988
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Harry W. Haverkos;Robert R. Edelman
  • 通讯作者:
    Robert R. Edelman
A comprehensive evaluation of the left atrium using cardiovascular magnetic resonance
使用心血管磁共振对左心房进行综合评估
  • DOI:
    10.1016/j.jocmr.2025.101852
  • 发表时间:
    2025-06-01
  • 期刊:
  • 影响因子:
    6.100
  • 作者:
    Maurice Pradella;Mohammed S.M. Elbaz;Daniel C. Lee;KyungPyo Hong;Rod S. Passman;Eugene Kholmovski;Dana C. Peters;Justin J. Baraboo;Daniel A. Herzka;Reza Nezafat;Robert R. Edelman;Daniel Kim
  • 通讯作者:
    Daniel Kim

Robert R. Edelman的其他文献

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{{ truncateString('Robert R. Edelman', 18)}}的其他基金

Twofold Reduction in Gadolinium Dose for Brain MRI Exams using a Novel Unbalanced T1 Relaxation-Enhanced Steady-State (uT1RESS) Technique
使用新型不平衡 T1 弛豫增强稳态 (uT1RESS) 技术将脑 MRI 检查的钆剂量减少两倍
  • 批准号:
    10507378
  • 财政年份:
    2022
  • 资助金额:
    $ 38.91万
  • 项目类别:
Twofold Reduction in Gadolinium Dose for Brain MRI Exams using a Novel Unbalanced T1 Relaxation-Enhanced Steady-State (uT1RESS) Technique
使用新型不平衡 T1 弛豫增强稳态 (uT1RESS) 技术将脑 MRI 检查的钆剂量减少两倍
  • 批准号:
    10671616
  • 财政年份:
    2022
  • 资助金额:
    $ 38.91万
  • 项目类别:
Improved Detection of Cerebral Metastases using a using a Novel T1 Relaxation-Enhanced Steady-State (T1RESS) MRI Technique
使用新型 T1 弛豫增强稳态 (T1RESS) MRI 技术改进脑转移瘤的检测
  • 批准号:
    10609032
  • 财政年份:
    2022
  • 资助金额:
    $ 38.91万
  • 项目类别:
Improved Detection of Cerebral Metastases using a using a Novel T1 Relaxation-Enhanced Steady-State (T1RESS) MRI Technique
使用新型 T1 弛豫增强稳态 (T1RESS) MRI 技术改进脑转移瘤的检测
  • 批准号:
    10440636
  • 财政年份:
    2022
  • 资助金额:
    $ 38.91万
  • 项目类别:
Nonenhanced 3T QISS MR Angiography of the Peripheral Arteries
非增强 3T QISS MR 外周动脉血管造影
  • 批准号:
    9766368
  • 财政年份:
    2015
  • 资助金额:
    $ 38.91万
  • 项目类别:
Non-Contrast Magnetic Resonance Angiography of Peripheral Vascular Disease
周围血管疾病的非对比磁共振血管造影
  • 批准号:
    8402153
  • 财政年份:
    2010
  • 资助金额:
    $ 38.91万
  • 项目类别:
Non-Contrast Magnetic Resonance Angiography of Peripheral Vascular Disease
周围血管疾病的非对比磁共振血管造影
  • 批准号:
    8034741
  • 财政年份:
    2010
  • 资助金额:
    $ 38.91万
  • 项目类别:
Non-Contrast Magnetic Resonance Angiography of Peripheral Vascular Disease
周围血管疾病的非对比磁共振血管造影
  • 批准号:
    8206849
  • 财政年份:
    2010
  • 资助金额:
    $ 38.91万
  • 项目类别:
Non-Contrast Magnetic Resonance Angiography of Peripheral Vascular Disease
周围血管疾病的非对比磁共振血管造影
  • 批准号:
    7786580
  • 财政年份:
    2010
  • 资助金额:
    $ 38.91万
  • 项目类别:
MR-Guided Endovascular Intervention Using Off-Resonance Contrast Angiography
使用非共振造影血管造影的 MR 引导血管内干预
  • 批准号:
    7588560
  • 财政年份:
    2009
  • 资助金额:
    $ 38.91万
  • 项目类别:

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激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
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