Evaluating the impact of fentanyl test strip use among rural and urban populations

评估芬太尼试纸使用对农村和城市人口的影响

• 批准号: 10440481
• 负责人: Nichole L Michaels
• 金额: $ 68.56万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10440481
• 关键词: Adoption; Age; Behavior; Cause of Death; Cluster randomized trial; Cocaine; Communities; Consumption; County; Data; Death Rate; Dose; Drug Addiction; Drug Prevention Program; Drug usage; Drug user; Education; Emergency Care; Ensure; Face; Fatality rate; Fentanyl; Goals; Harm Reduction; Health; Heroin; Home; Illicit Drugs; Individual; Ingestion; Intervention; Knowledge; Materials Testing; Methadone; Morbidity - disease rate; Naloxone; Nature; Ohio; Opioid; Opioid Analgesics; Outcome; Overdose; Overdose reduction; Pharmaceutical Preparations; Policy Maker; Population; Public Health; Publishing Peer Reviews; Research; Research Support; Risk; Risk Reduction Behavior; Rural; Rural Community; Rural Population; Sampling; Self Efficacy; Site; Test Result; Testing; Time; Tramadol; United States; Urban Community; Urban Population; Urine; acceptability and feasibility; analog; arm; base; comparison intervention; design; drug testing; experience; health disparity; high risk population; improved; intervention program; mortality; off-label use; opioid epidemic; opioid mortality; opioid overdose; overdose death; overdose education; overdose risk; pill; prevent; programs; synthetic opioid; test strip; trial design

Project Summary The increasing pervasiveness of highly lethal fentanyl and fentanyl analogs in the illicit drug supply in the United States, including Ohio, has posed a substantial challenge for public health officials seeking interventions to reduce unintentional overdoses. Rapid fentanyl test strips, designed to test for the presence of fentanyl and some fentanyl analogs in urine samples, are increasingly being used off-label by people who use drugs to test illicit drugs for fentanyl before consumption. Recent research indicates that when people who use drugs receive a positive fentanyl test result, they are more likely to perform overdose risk reduction behaviors (e.g., using less of the drug). However, due to the emergent nature of this harm reduction strategy, peer- reviewed published research on this topic is very limited. We propose to test an intervention to provide fentanyl test strip education and distribution to people who use drugs in a subset of opioid overdose education and naloxone distribution sites in rural and urban counties in Ohio. The long-term goal of this research is the reduction of overdose-related morbidity and mortality in Ohio and nationally. The research objectives of this study are: 1) Determine the feasibility and acceptability of providing fentanyl test strip education and testing materials distribution in existing opioid overdose education and naloxone distribution programs; and 2) Determine if adding fentanyl test strip education and distribution to opioid overdose education and naloxone distribution programs decreases opioid overdose rates among people who use drugs. Using a two-arm cluster- randomized trial design, we will answer the research objectives by testing the following 3 specific aims: 1) Determine the perceived barriers and facilitating factors associated with incorporating fentanyl test strip education and distribution in existing opioid overdose education and naloxone distribution programs in rural and urban counties; 2) Test the hypothesis that people who use drugs who receive fentanyl test strip education and testing materials as part of an opioid overdose education and naloxone distribution program will have improved knowledge and self-efficacy regarding how to test drugs for fentanyl and strategies for lowering their risk of an opioid overdose; and 3) Test the hypothesis that individuals who receive fentanyl test strip education and testing materials as part of an opioid overdose education and naloxone distribution program will have a lower opioid overdose rate than individuals who receive opioid overdose education and naloxone distribution only (“usual practice”). Fentanyl test strip use is becoming more common, but research supporting the practice is limited. We will investigate the feasibility, acceptability, and associated benefits and harms of integrating fentanyl test strip education and distribution into existing opioid overdose education and naloxone distribution programs in rural and urban communities.

项目概要 高致命性芬太尼和芬太尼类似物在非法药物供应中日益普遍 美国，包括俄亥俄州，对公共卫生官员寻求帮助提出了巨大的挑战 减少意外用药过量的干预措施。芬太尼快速试纸，旨在测试是否存在 尿液样本中的芬太尼和一些芬太尼类似物越来越多地被使用的人超说明书使用 在消费前测试非法药物中芬太尼的药物。最近的研究表明，当人们使用 药物收到芬太尼测试结果呈阳性，他们更有可能执行减少服用过量风险的行为 （例如，减少药物用量）。然而，由于这种减少危害战略的新兴性质，同行 已发表的有关该主题的研究非常有限。我们建议测试提供芬太尼的干预措施 在阿片类药物过量教育的一部分中，向吸毒者进行试纸教育和分发，以及 俄亥俄州农村和城市县的纳洛酮分销点。这项研究的长期目标是 减少俄亥俄州和全国与药物过量相关的发病率和死亡率。本课题的研究目的 研究内容是： 1) 确定提供芬太尼试纸教育和测试的可行性和可接受性 现有阿片类药物过量教育和纳洛酮分发计划中的材料分发；和 2) 确定是否将芬太尼试纸教育和分发添加到阿片类药物过量教育和纳洛酮中 分发计划降低了吸毒者中阿片类药物的过量使用率。使用两臂集群- 随机试验设计，我们将通过测试以下3个具体目标来回答研究目标：1） 确定与加入芬太尼试纸相关的感知障碍和促进因素 农村现有阿片类药物过量教育和纳洛酮分配方案的教育和分配 和城市县； 2) 检验以下假设：吸毒者接受芬太尼试纸教育 作为阿片类药物过量教育和纳洛酮分发计划的一部分，测试材料将具有 提高有关如何测试芬太尼药物以及降低芬太尼水平的策略的知识和自我效能 阿片类药物过量的风险； 3) 检验接受芬太尼试纸教育的个体的假设 作为阿片类药物过量教育和纳洛酮分发计划的一部分，测试材料将有一个 与接受阿片类药物过量教育和纳洛酮分配的个人相比，阿片类药物过量率较低 仅（“通常做法”）。芬太尼试纸的使用变得越来越普遍，但研究支持这种做法 是有限的。我们将调查整合的可行性、可接受性以及相关的利弊 将芬太尼试纸教育和分发纳入现有阿片类药物过量教育和纳洛酮分发 农村和城市社区的计划。