Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementia

教育质量和职业复杂性对大脑健康和阿尔茨海默病及相关痴呆症中种族和民族不平等的影响

基本信息

  • 批准号:
    10440345
  • 负责人:
  • 金额:
    $ 35.33万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-15 至 2024-05-31
  • 项目状态:
    已结题

项目摘要

ABSTRACT By 2050 nearly 14 million people will suffer from Alzheimer's disease and related dementias (ADRD) in the US and minorities will be disproportionally burdened. While it is known that certain racial/ethnic groups, such as African Americans, have higher rates of dementia, reasons for disparities are unknown. Though education and occupation are robustly associated with ADRD, research on education quality and occupational complexity has primarily included only Whites or, when examining racial/ethnic differences, focused on comparisons between Whites and African Americans. We propose to examine the role of educational quality and occupational complexity on cognitive decline, ADRD, and imaging markers of vascular brain injury and neurodegeneration in a cohort with unparalleled racial/ethnic diversity. The proposed study derives measures of education quality and occupational complexity, building upon the following rich data sources at Kaiser Permanente Northern California: detailed social and physical measures from a Multiphasic Health Checkup completed during the 1960s to 1990s; electronic medical records from 1996 onward; and detailed social, cognitive, and neuroimaging measures from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study assessments. KHANDLE collects the names and locations of schools attended at 1st, 6th, 9th, and 12th grades as well as college or university attended which will be linked to historical indicators of school quality. Comprehensive information collected regarding occupation enables delineation of occupational complexity in early-, mid-, and late-adulthood. Utilizing these comprehensive data sources, we are in a unique position to successfully complete the aims of the study, which are to: 1) Evaluate the roles of education quality on cognitive decline, ADRD incidence, and imaging markers of vascular brain injury and neurodegeneration in African American, White, Asian, and Latino individuals; 2) Examine the role of occupational complexity on cognitive decline, ADRD incidence, and imaging markers of vascular brain injury and neurodegeneration in this diverse cohort; 3) Delineate if patterns of educational quality and occupational complexity across the lifecourse mediate racial and ethnic disparities in ADRD, cognitive decline, and imaging markers of vascular brain injury and neurodegeneration. Utilizing a lifecourse approach, as recommended by the NIH State of the Science on Preventing Cognitive Decline, the proposed research will add vital information regarding the characteristics and timing of education quality and occupational complexity characteristics associated with ADRD and may inform future interventions aiming to improve cognition among elderly of all racial/ethnic groups. Given the marked disparities in ADRD rates by racial/ethnic groups there has never been a more critical time to understand how sociocontextual risk factors impact brain health in diverse populations.
摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Paola Gilsanz其他文献

Paola Gilsanz的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Paola Gilsanz', 18)}}的其他基金

Glycemic Control and Dementia: The Role of Pharmacotherapy and Vascular Complications
血糖控制和痴呆:药物治疗和血管并发症的作用
  • 批准号:
    10348191
  • 财政年份:
    2020
  • 资助金额:
    $ 35.33万
  • 项目类别:
Glycemic Control and Dementia: The Role of Pharmacotherapy and Vascular Complications
血糖控制和痴呆:药物治疗和血管并发症的作用
  • 批准号:
    10557206
  • 财政年份:
    2020
  • 资助金额:
    $ 35.33万
  • 项目类别:
Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementia
教育质量和职业复杂性对大脑健康和阿尔茨海默氏病及相关痴呆症中种族和民族不平等的影响
  • 批准号:
    10221594
  • 财政年份:
    2019
  • 资助金额:
    $ 35.33万
  • 项目类别:
Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementia
教育质量和职业复杂性对大脑健康和阿尔茨海默病及相关痴呆症中种族和民族不平等的影响
  • 批准号:
    10642798
  • 财政年份:
    2019
  • 资助金额:
    $ 35.33万
  • 项目类别:
Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementia
教育质量和职业复杂性对大脑健康和阿尔茨海默病及相关痴呆症中种族和民族不平等的影响
  • 批准号:
    10017859
  • 财政年份:
    2019
  • 资助金额:
    $ 35.33万
  • 项目类别:
Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementia
教育质量和职业复杂性对大脑健康和阿尔茨海默病及相关痴呆症中种族和民族不平等的影响
  • 批准号:
    9891809
  • 财政年份:
    2019
  • 资助金额:
    $ 35.33万
  • 项目类别:
Study of Healthy Aging in African Americans
非裔美国人健康老龄化研究
  • 批准号:
    10739238
  • 财政年份:
    2017
  • 资助金额:
    $ 35.33万
  • 项目类别:
Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)
痴呆症的生命周期健康、脑病理学和种族差异(KHANDLE 研究)
  • 批准号:
    10666493
  • 财政年份:
    2016
  • 资助金额:
    $ 35.33万
  • 项目类别:
Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)
痴呆症的生命周期健康、脑病理学和种族差异(KHANDLE 研究)
  • 批准号:
    10468140
  • 财政年份:
    2016
  • 资助金额:
    $ 35.33万
  • 项目类别:
Short and long term depressive symptoms and arrhythmic pathways to stroke
短期和长期抑郁症状以及心律失常导致中风的途径
  • 批准号:
    8257465
  • 财政年份:
    2012
  • 资助金额:
    $ 35.33万
  • 项目类别:

相似海外基金

A neuroimaging approach to advance mechanistic understanding of tobacco use escalation risk among young adult African American vapers
一种神经影像学方法,可促进对年轻非洲裔美国电子烟使用者烟草使用升级风险的机制理解
  • 批准号:
    10509308
  • 财政年份:
    2022
  • 资助金额:
    $ 35.33万
  • 项目类别:
Understanding social undermining of weight management behaviors in young adult African American women
了解年轻非洲裔美国女性体重管理行为的社会破坏
  • 批准号:
    10680412
  • 财政年份:
    2022
  • 资助金额:
    $ 35.33万
  • 项目类别:
Understanding social undermining of weight management behaviors in young adult African American women
了解年轻非洲裔美国女性体重管理行为的社会破坏
  • 批准号:
    10535890
  • 财政年份:
    2022
  • 资助金额:
    $ 35.33万
  • 项目类别:
A neuroimaging approach to advance mechanistic understanding of tobacco use escalation risk among young adult African American vapers
一种神经影像学方法,可促进对年轻非洲裔美国电子烟使用者烟草使用升级风险的机制理解
  • 批准号:
    10629374
  • 财政年份:
    2022
  • 资助金额:
    $ 35.33万
  • 项目类别:
Impact of Adult Day Services on Psychosocial and Physiological Measures of Stress among African American Dementia Family Caregivers
成人日间服务对非裔美国痴呆症家庭护理人员的社会心理和生理压力测量的影响
  • 批准号:
    10553725
  • 财政年份:
    2021
  • 资助金额:
    $ 35.33万
  • 项目类别:
Voice-Activated Technology to Improve Mobility & Reduce Health Disparities: EngAGEing African American Older Adult-Care Partner Dyads
语音激活技术可提高移动性
  • 批准号:
    10494191
  • 财政年份:
    2021
  • 资助金额:
    $ 35.33万
  • 项目类别:
Impact of Adult Day Services on Psychosocial and Physiological Measures of Stress among African American Dementia Family Caregivers
成人日间服务对非裔美国痴呆症家庭护理人员的社会心理和生理压力测量的影响
  • 批准号:
    10328955
  • 财政年份:
    2021
  • 资助金额:
    $ 35.33万
  • 项目类别:
Voice-Activated Technology to Improve Mobility & Reduce Health Disparities: EngAGEing African American Older Adult-Care Partner Dyads
语音激活技术可提高移动性
  • 批准号:
    10437374
  • 财政年份:
    2021
  • 资助金额:
    $ 35.33万
  • 项目类别:
Voice-Activated Technology to Improve Mobility & Reduce Health Disparities: EngAGEing African American Older Adult-Care Partner Dyads
语音激活技术可提高移动性
  • 批准号:
    10654831
  • 财政年份:
    2021
  • 资助金额:
    $ 35.33万
  • 项目类别:
Development, Implementation, and Evaluation of a Smoking Cessation Intervention Tailored to Rural Young Adult African American Men: Toward Scalability
针对农村年轻非裔美国男性的戒烟干预措施的制定、实施和评估:走向可扩展性
  • 批准号:
    9896786
  • 财政年份:
    2018
  • 资助金额:
    $ 35.33万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了