权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Effect of Indoor Fine Particulate Matter Exposure on Respiratory Health Outcomes in Premature Infants

室内细颗粒物暴露对早产儿呼吸健康结果的影响

基本信息

批准号：
10440458
负责人：
Jessica Lynne Rice
金额：
$ 20.86万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10440458
关键词：
Adult Affect Age-Months Air Asthma Baltimore Bronchopulmonary Dysplasia Caring Child Childhood Childhood Asthma Chronic Chronic lung disease Clinic Clinical Clinical Trials Cotinine Coughing Data Development Disease Education Emergency department visit Enrollment Environmental Epidemiology Environmental Health Event Exposure to Funding Future Gestational Age Goals Growth Health Health Policy Healthcare Home Hospitalization Hospitals Indoor Air Pollution Indoor Air Quality Infant Infant Mortality Inhalation Interdisciplinary Study International Intervention Intervention Trial K-Series Research Career Programs Life Link Lung Lung diseases Measurement Measures Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methods Morbidity - disease rate National Institute of Environmental Health Sciences Nicotine Nursery Schools Observational Study Obstructive Lung Diseases Outcome Outpatients Particulate Matter Pathology Patients Pharmaceutical Preparations Pilot Projects Pollution Population Pregnancy Pregnant Women Premature Birth Premature Infant Primary Health Care Prospective cohort study Public Policy Pulmonology Randomized Controlled Trials Registries Research Research Personnel Respiratory Signs and Symptoms Rice Risk Risk Factors Salivary Secondary to Smoker Smoking Source Steroids Symptoms Testing Time Tissues Training United States Environmental Protection Agency Visit Vulnerable Populations Wheezing aged base career clinical care clinical practice cohort design early childhood environmental tobacco smoke environmental tobacco smoke exposure experience fine particles follow-up health care service utilization high risk improved indoor air indoor particulate matter infancy inner city interest lung development modifiable risk monitoring device multi-component intervention premature prevent primary outcome programs prospective pulmonary function recruit respiratory respiratory health respiratory morbidity secondary outcome skills skills training suburb success urban setting urgent care

项目摘要

Project Abstract and Summary This mentored Patient-Oriented Research Career Development Award will provide Dr. Jessica Rice with the experience and training to become an independent investigator in pediatric pulmonology with a focus on the effects of indoor air pollution (fine particulate matter, PM2.5) on respiratory morbidity in premature infants. Premature birth affects 10 percent of infants born in the U.S. and is the leading cause of infant mortality. Bronchopulmonary dysplasia (BPD) is one of the most common and serious complications of preterm birth and infants are at risk for chronic respiratory symptoms and lung function abnormalities throughout childhood and into adulthood. While exposure to indoor air pollution has been shown to be detrimental in other populations (children with asthma) and secondhand smoke (SHS) exposure has been linked to adverse respiratory outcomes in premature infants, the effect of measured indoor PM2.5 on respiratory outcomes in a vulnerable population of premature infants is not known. The central hypothesis is that exposure to PM2.5 leads to an increased risk of respiratory-related morbidity among premature infants. To test this hypothesis, we propose a prospective observational study evaluating the effect of PM2.5 in two cohorts of patients who will be followed for one year. The first cohort will be recruited at the time of initial hospital discharge and will include infants born ≤ 32 weeks (with and without BPD) (aim 1) and the second cohort will include preschool aged children who were born prematurely with established BPD (aim 2). These two cohorts will allow us to evaluate a full clinical spectrum of chronic lung disease related to prematurity. Outcomes will include healthcare utilization, medication use, symptoms, and markers of SHS exposure (air nicotine and salivary cotinine). The goal of this proposal is to collect preliminary data and obtain the necessary training and skills in environmental epidemiology and clinical trial methods in order to design a future intervention trial to evaluate the impact improving indoor air quality in this population. This approach focuses on identifying a modifiable risk factor and intervening early when developing tissues are most susceptible to environmental insults in order to prevent disease. Results of this study have the potential to impact clinical practice and eventually, public policy. Dr. Rice has assembled a multidisciplinary research team with extensive research and mentorship experience. Her primary mentor, Dr. Gregory Diette is the co-director of the EPA/ NIEHS funded Center for Childhood Asthma in the Urban Environment and is an international expert on inner city exposures and their contribution to obstructive lung disease. Her co-mentors Dr. Sharon McGrath-Morrow and Dr. J. Michael Collaco, are both pediatric pulmonologists and experts in the field of chronic lung disease of prematurity. Dr. Kirsten Koehler, an expert in environmental health science will provide guidance related to exposure measurement and analysis. This career development award will provide Dr. Rice with the necessary skills, training, and mentorship needed to develop her research program and will be key to her success in transitioning to an independent investigator.

项目摘要及总结这项以患者为导向的研究职业发展奖将为杰西卡·赖斯博士提供成为儿科肺病学独立研究者的经验和培训，重点关注室内空气污染（细颗粒物，PM2.5）对早产儿呼吸道疾病的影响。早产影响美国出生婴儿的 10%，是婴儿死亡的主要原因。支气管肺发育不良（BPD）是早产和早产最常见和最严重的并发症之一婴儿在整个童年时期都面临慢性呼吸道症状和肺功能异常的风险进入成年期。虽然暴露于室内空气污染已被证明对其他人群有害（患有哮喘的儿童）和二手烟（SHS）暴露与呼吸道不良有关早产儿的结果，测量的室内 PM2.5 对弱势群体呼吸系统结果的影响早产儿的数量尚不清楚。核心假设是，暴露于 PM2.5 会导致早产儿发生呼吸系统相关疾病的风险增加。为了检验这个假设，我们提出了一个前瞻性观察性研究，评估 PM2.5 对两组患者的影响，并对其进行随访一年。第一批将在首次出院时招募，包括出生≤ 32 周（有或没有 BPD）（目标 1），第二组将包括患有 BPD 的学龄前儿童患有 BPD 的早产儿（目标 2）。这两个队列将使我们能够评估完整的临床与早产相关的一系列慢性肺部疾病。结果将包括医疗保健利用、药物使用、症状和二手烟暴露标志物（空气尼古丁和唾液可替宁）。此举的目标建议收集初步数据并获得环境方面必要的培训和技能流行病学和临床试验方法，以便设计未来的干预试验来评估影响改善该人群的室内空气质量。该方法侧重于识别可改变的风险因素和当发育中的组织最容易受到环境损害时进行早期干预，以防止疾病。这项研究的结果有可能影响临床实践，并最终影响公共政策。博士。莱斯组建了一支具有丰富研究和指导经验的多学科研究团队。她首席导师 Gregory Diette 博士是 EPA/NIEHS 资助的儿童哮喘中心的联合主任城市环境领域的专家，是内城风险及其对城市贡献的国际专家阻塞性肺病。她的共同导师 Sharon McGrath-Morrow 博士和 J. Michael Collaco 博士都是儿科肺科医生和早产儿慢性肺病领域的专家。克尔斯滕·科勒 (Kirsten Koehler) 博士环境健康科学专家将提供与暴露测量和分析相关的指导。该职业发展奖将为莱斯博士提供必要的技能、培训和指导制定她的研究计划，这将是她成功转型为独立调查员的关键。