Approach Bias Modification for the Treatment of Cannabis Use Disorder
Approach Bias Modification for the Treatment of Cannabis Use Disorder
批准号:
10440451
负责人:
Brian Sherman
金额:
$18.55万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-07-15 至 2023-06-30
关键词:
AbstinenceAdultAgeAlcohol consumptionAlcohol dependenceAlcoholsAmericanAttenuatedCannabinoidsCannabisChronicClinical TrialsCognitiveCreatinineCuesDataDependenceDevelopmentDouble-Blind MethodDrug ExposureDrug usageEvaluationFDA approvedFunctional Magnetic Resonance ImagingFutureGalvanic Skin ResponseGenderGoalsImpaired cognitionInterventionInvestigationK-Series Research Career ProgramsLaboratoriesMaintenanceMental HealthModelingModificationNeuropsychologyNicotineNicotine DependenceNicotine Use DisorderOpioidOutcomeParticipantPatient Self-ReportPersonsPharmaceutical PreparationsPharmacologyPhysiologicalPilot ProjectsPlayPrevalenceProcessRandomizedRelapseReportingResponse to stimulus physiologyRewardsRoleSeveritiesSite-Directed MutagenesisStimulusTestingToxicologyTrainingTreatment outcomeUnited StatesUrineWomanaddictionalcohol cuealcohol relapsealcohol responsealternative treatmentattenuationbasecognitive processcomputerizedcost efficientcravingcue reactivityeffective therapyefficacy evaluationfollow-upgender differenceimprovedincentive saliencemarijuana usemarijuana use disordermarijuana usermennicotine usenovelphysical conditioningprimary outcomepsychosocialrecruitrelating to nervous systemresearch studyresponseside effecttherapeutic targettreatment trialtrend
中文摘要
项目摘要/摘要
英文摘要
PROJECT SUMMARY / ABSTRACT
Cannabis use disorder (CUD) is increasingly common, yet available treatments are inadequate. To date there
are no FDA-approved medications, and while psychosocial interventions are modestly effective, their durability
is limited and abstinence rates are low. Investigation of novel adjunctive treatments for CUD is warranted.
Biases in cognitive processing of drug-related stimuli play an important role in the development and maintenance
of addictive disorders. Growing evidence suggests that attenuation of drug-related automatic approach
tendencies offers a promising new treatment approach. Approach bias modification (ABM) involves manipulating
stimulus-response contingencies during a computerized task in order to attenuate approach bias and reduce
drug use. In recent clinical trials, ABM reduced alcohol relapse rates by 10-13% at one-year follow-up, decreased
mesolimbic neural activity in response to alcohol cues, and reduced nicotine consumption and dependence
severity. ABM has not yet been tested with cannabis users.
The candidate recently completed a four-session laboratory-based pilot study demonstrating that ABM training
is safe, tolerable, and feasible in non-treatment seeking adults with CUD (N=33). Participants receiving ABM
showed blunted cannabis cue-induced craving, and there was a trend for gender modification of ABM on
cannabis use. Given these promising preliminary findings, ABM may be a powerful adjunct to existing
psychosocial interventions.
In the proposed career development award, the candidate aims to determine if a four-session intervention
combining ABM with MET/CBT can reduce cannabis cue-induced reactivity (Aim 1) and improve cannabis use
outcomes (Aim 2) in treatment-seeking adults with CUD. Additionally, the candidate will determine if gender
moderates the effect of ABM on cue-reactivity and cannabis use (Exploratory Aim). Development of a novel,
effective treatment for CUD would have the potential to help the estimated one million cannabis using Americans
that seek treatment each year. Of note, ABM has no side effects, is cost-efficient, and may focally target cognitive
mechanisms associated with CUD.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Is it time for a cannabis harm reduction approach? Commentary on Sherman et al. (2022) and Borodovsky et al. (2022).
是时候采取减少大麻危害的方法了吗?
DOI:
10.1037/adb0000927
发表时间:
2023
期刊:
Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
影响因子:
--
作者:
[Stone,BryantM, Sherman,BrianJ]
通讯作者:
Sherman,BrianJ
Cortisol reactivity and situational drug use in cocaine-dependent females.
可卡因依赖女性的皮质醇反应性和情境药物使用。
DOI:
10.1016/j.psychres.2019.112611
发表时间:
2019
期刊:
Psychiatry research
影响因子:
11.3
作者:
[Campbell,Lauren, Galuska,Chad, McRae-Clark,Aimee, Sherman,Brian]
通讯作者:
Sherman,Brian
Exogenous progesterone for cannabis withdrawal in women: Feasibility trial of a novel multimodal methodology.
用于女性大麻戒断的外源性黄体酮:新型多模式方法的可行性试验。
DOI:
10.1016/j.pbb.2019.01.008
发表时间:
2019
期刊:
Pharmacology, biochemistry, and behavior
影响因子:
--
作者:
[Sherman,BrianJ, Caruso,MargaretA, McRae-Clark,AimeeL]
通讯作者:
McRae-Clark,AimeeL
海外基金