Multisensory interventions to improve neurodevelopmental outcomes of preterm infants hospitalized in the neonatal intensive care unit

多感官干预可改善新生儿重症监护病房住院早产儿的神经发育结局

• 批准号: 10443363
• 负责人: Amit Mohan Mathur
• 金额: $ 68.29万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10443363
• 关键词: 2 year old; Address; Age; Attention; Auditory; Behavioral; Biological Markers; Birth; Brain; Caring; Cerebrum; Complex; Cues; Development; Dose; Electroencephalography; Emotional; Enrollment; Environment; Environmental Exposure; Equilibrium; Evidence based intervention; Exposure to; Family; Future; Goals; Health; Hospitalization; Hospitals; Hour; Human; Infant; Intervention; Knowledge; Language; Life; Masks; Massage; Measures; Medical; Mental Health; Monitor; Music; Neonatal Intensive Care Units; Newborn Infant; Outcome; Pain; Parent-Child Relations; Parents; Pathway interactions; Pattern; Personal Satisfaction; Pregnancy; Premature Infant; Process; Public Health; Publishing; Randomized; Reporting; Research; Risk; Sampling; Sensory; Sensory Thresholds; Skin; Skin Care; Standardization; Stimulus; Structure; Tactile; Testing; Time; Toddler; Touch sensation; Veins; Work; base; early experience; evidence base; experience; high risk infant; improved; improved outcome; infant outcome; intervention program; language outcome; multisensory; neonatal brain; neurodevelopment; premature; primary outcome; procedural pain; programs; sensory mechanism; sensory stimulus; social; standard of care; therapy design; tool; volunteer

Project Summary The long-term goal of this project is to improve the health and well-being of preterm infants and their parents. Very preterm infants necessitate medical care in the neonatal intensive care unit (NICU) at birth and can be hospitalized for their first several months of life, where they are exposed to repetitive, painful stimuli, are separated from their parents, and often do not receive positive, timed sensory exposures that are similar to what they would have received if not born early. In addition, parents often do not know when and how to engage with their infant in the NICU. However, early positive sensory experiences are important, as they enhance brain development during an important period of time and can be used as a tool to help parents participate during NICU hospitalization and establish early parent-child relationships to optimize development. Although there is evidence to support positive multisensory interventions in the NICU, these interventions are often applied in an inconsistent manner, reducing their benefit. Through a rigorous and scientific process, we have developed a structured multisensory intervention program, titled Supporting and Enhancing NICU Sensory Experiences (SENSE), which includes specific doses and targeted timing of evidence-based interventions such as massage, auditory exposure, rocking, holding, and skin-to-skin care. The interventions are based on the infant’s developmental stage and are adapted based on the infant’s medical status and behavioral cues. The multisensory interventions are designed to be conducted during each day of NICU hospitalization by the parents, who are educated and supported to provide them. A sensory support team fills in gaps when parents are unable to reach the targeted amount of sensory exposures each day. The proposed work aims to determine the effect of multisensory interventions on parent mental health, parent-child interaction, brain activity (amplitude integrated electroencephalography), and infant developmental outcomes through age 2 years, with specific attention to language outcome. Two-hundred fifteen parent-infant dyads of preterm infants born ≤ 32 weeks gestation and admitted to a Level IV NICU will be enrolled within 1 week of birth. Infants will be randomized to either the SENSE multisensory program or to the standard of care during the NICU stay. The SENSE program combines structured, easy-to-conduct, multisensory interventions with parent engagement to optimize outcomes in the complex medical environment of the NICU. Standardized assessments of parent mental health, infant neurodevelopment, and parent-child interaction will be conducted prior to NICU discharge and at 6 months, 1 year, and 2 years, adjusted for prematurity. Differences between groups will be investigated. Brain activity during NICU stay, including in the presence and absence of different sensory exposures, will also be investigated. The expected outcome is that the SENSE multisensory program will have a positive effect on improving outcomes. Importantly, the SENSE program has been implemented with ease in >250 hospitals in the US and abroad, so there is great potential for broad and long-term impact.

项目摘要 该项目的长期目标是改善早产儿及其父母的健康和福祉。 极早产儿出生时需要在新生儿重症监护室（NICU）接受医疗护理， 在他们生命的头几个月住院，在那里他们暴露于重复的，痛苦的刺激， 与父母分离，并且通常不会接受类似于 如果他们不早出生他们会得到什么。此外，父母往往不知道何时以及如何 在新生儿重症监护室里与他们的婴儿接触。然而，早期积极的感官体验很重要，因为它们 在重要的时期促进大脑发育，可作为帮助父母的工具 在NICU住院期间参与，并建立早期的亲子关系，以优化发展。 虽然有证据支持NICU中的积极多感觉干预，但这些干预措施 通常以不一致的方式应用，减少了它们的益处。通过严格的科学程序，我们 我开发了一个结构化的多感官干预计划，名为支持和加强新生儿重症监护室 感官体验（SENSE），其中包括特定剂量和有针对性的循证时间 干预，如按摩，听觉暴露，摇摆，持有，和皮肤对皮肤护理。的干预措施 基于婴儿的发育阶段，并根据婴儿的医疗状况进行调整， 行为线索多感觉干预设计为在NICU的每一天进行 父母住院治疗，他们受到教育和支持，以提供这些服务。一个感官支持团队 当父母无法达到每天感官接触的目标量时，拟议 这项工作旨在确定多感官干预对父母心理健康的影响， 互动、脑活动（振幅整合脑电图）和婴儿发育结果 到2岁，特别注意语言结果。215对父母-婴儿 妊娠≤ 32周出生并入住IV级NICU的早产儿将在以下时间1周内入组 出生婴儿将被随机分配至SENSE多感觉程序或标准护理， 新生儿重症监护室还在SENSE计划结合了结构化，易于进行，多感官干预， 家长参与，以优化NICU复杂医疗环境中的结果。标准化 将对父母的心理健康、婴儿的神经发育和亲子互动进行评估 在NICU出院前以及6个月、1年和2年时，根据早产进行调整。差异 团体将进行调查。NICU住院期间的大脑活动，包括存在和不存在不同的 感官暴露也将进行调查。预期的结果是，SENSE多感官项目 将对改善结果产生积极影响。重要的是，SENSE计划已经实施， 在美国和国外的250多家医院中轻松使用，因此具有广泛和长期影响的巨大潜力。