3D Ultra-sensitive Ultrasound Microvessel Imaging for Breast Mass Differentiation

3D 超灵敏超声微血管成像用于乳腺肿块分化

• 批准号: 10442667
• 负责人: Shigao Chen
• 金额: $ 7.95万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10442667
• 关键词: 3-Dimensional; Acoustics; Affect; American; American Cancer Society; Anxiety; Benign; Biological Markers; Biopsy; Blood Vessels; Breast; Cancer Etiology; Cessation of life; Classification; Clinical; Clinical Research; Code; Contrast Media; Custom; Development; Diagnosis; Diagnostic; Doppler Ultrasound; Enhancement Technology; Ensure; Evaluation; Favorable Clinical Outcome; Goals; Gold; Image; Imaging Techniques; Imaging technology; Investigation; Light; Lobe; Malignant Neoplasms; Mammary Neoplasms; Mammography; Mass in breast; Methods; Morphologic artifacts; Pathology; Patients; Penetration; Research; Scanning; Screening for cancer; Side; Specificity; Techniques; Technology; Testing; Three-Dimensional Imaging; Tissues; Tumor Angiogenesis; Tumor Pathology; Ultrasonography; United States; Woman; breast cancer diagnosis; breast imaging; cancer diagnosis; cost; cost effective; detection sensitivity; diagnostic accuracy; experience; imaging modality; improved; malignant breast neoplasm; novel; radiologist; recruit; transmission process; tumor; tumor diagnosis; two-dimensional; ultrasound

PROJECT SUMMARY Breast cancer, the second-leading cause of cancer deaths among women, affects millions of Americans. Early cancer detection and accurate tumor diagnosis are crucial for favorable clinical outcomes. Ultrasonography (US) is an important imaging modality adjunct to mammography as it is noninvasive, cost-effective, and widely available. However, the low specificity of US limits its diagnosis accuracy, even in combination with mammography. The resultant unnecessary benign biopsies substantially increase patients’ cost and anxiety. Tumor angiogenesis can be used as a valuable biomarker for better breast tumor US differentiation. However, conventional Doppler imaging has insufficient vessel detection sensitivity. We have recently developed a novel 2-dimensional ultra-sensitive ultrasound microvessel imaging (2D-UMI) technology, which demonstrates significantly increased vessel detection sensitivity over conventional Doppler methods without the need of using contrast agents. In our preliminary study, the diagnosis accuracy of combining US with 2D-UMI was improved by 15% compared to using conventional US alone. However, 2D tumor vascularity evaluation may be incomprehensive as most tumors are heterogeneous. In the proposed research, the 2D-UMI technique will be advanced to 3D imaging, and further enhanced to provide a comprehensive tumor vessel investigation to improve breast tumor classification accuracy and reduce unnecessary benign biopsies. In light of clinical need and our recent diagnostic development, this proposal has two specific aims: Specific Aim 1: Develop and enhance the 3D-UMI scanning sequence. We will develop the UMI sequence in 3D imaging using a Verasonics Vantage research scanner. We will apply multiple coded plane wave transmissions to ensure sufficient incident acoustic energy and ultrasound penetration. We will also develop new tissue clutter filters to eliminate the banding side-lobe artifacts caused by strong reflectors in breast imaging. We will then use a custom flow phantom to test and enhance the technology, and pave the way for the clinical study in Aim 2. Specific Aim 2: Conduct a pilot clinical study of 3D-UMI on patients with breast masses. We will study 42 patients with breast tumors to assess the 3D-UMI’s efficacy in improving breast tumor classification. An experienced radiologist will evaluate the results. We will then compare the diagnosis accuracy (using pathology as the gold standard) between the combined diagnosis of conventional US plus 3D-UMI versus use of conventional US alone. Successful completion of the proposed research will lead to a novel ultra-sensitive 3D Doppler technology to facilitate diagnosis of breast tumors with high accuracy.

项目总结 乳腺癌是女性癌症死亡的第二大原因，影响着数百万美国人。早些时候 癌症检测和准确的肿瘤诊断对于良好的临床结果至关重要。超声检查 (US)是乳房X光检查的一种重要的成像方式，因为它是非侵入性的、经济有效的和广泛的 可用。然而，US的低特异性限制了其诊断的准确性，即使与 乳房X光检查。由此产生的不必要的良性活检大大增加了患者的成本和焦虑。 肿瘤血管生成可作为提高乳腺肿瘤分化程度的有价值的生物标志物。然而， 常规的多普勒成像对血管的检测灵敏度不足。 我们最近开发了一种新的二维超灵敏超声微血管成像(2D-UMI) 这项技术表明，与传统的多普勒相比，血管检测灵敏度显著提高 方法不需要使用造影剂。在我们的初步研究中，诊断的准确性 与单独使用常规超声相比，联合使用US和2D-UMI改善了15%。但是，2D 由于大多数肿瘤是异质性的，肿瘤血管评估可能是不全面的。在建议的 研究表明，2D-UMI技术将向3D成像方向发展，并进一步增强以提供 全面的肿瘤血管调查，提高乳腺肿瘤分类准确率，减少 不必要的良性活检。 根据临床需要和我们最近的诊断发展，这项建议有两个具体目标： 具体目标1：开发和增强3D-UMI扫描序列。我们将开发UMI 使用Verasonics Vantage研究扫描仪进行3D成像。我们将应用多个编码平面 波的传输，以确保足够的入射声能和超声波穿透。我们还将 开发新的组织杂波过滤器以消除强反射引起的条带旁瓣伪影 乳房成像。然后，我们将使用自定义流模型来测试和增强该技术，并为 目标2中的临床研究方法。 具体目标2：对乳腺肿块患者进行3D-UMI的初步临床研究。我们会 以42例乳腺肿瘤患者为研究对象，评价3D-UMI改善乳腺肿瘤的疗效 分类。经验丰富的放射科医生将对结果进行评估。然后我们会比较诊断结果 常规超声联合诊断的准确性(以病理为金标准) 3D-UMI与仅使用传统美国的对比。 拟议研究的成功完成将导致一种新的超灵敏3D多普勒技术 有助于乳腺肿瘤的诊断，准确率高。