Core B: The Muscle Tissue/Cell Repository and Specialty Diagnostics Core

核心B摘要 爱荷华州韦尔斯通肌营养不良合作社的肌肉组织/细胞培养/诊断核心 研究中心是一个多方面的实验室，作为一个地方，国家和国际资源， 研究肌肉萎缩症和其他神经肌肉疾病。这个核心有两个主要目标。首先 已经建立并将扩大组织和细胞培养库，以支持基础和转化研究 努力目前，该存储库包含来自8500多名神经肌肉疾病患者的肌肉活检。 疾病，以及来自超过425名肌病患者的冷冻保存的成纤维细胞， 主要是肌肉萎缩症。来自核心的良好表征的组织和细胞可用于 研究调查员在爱荷华州以及其他学术中心在美国和世界各地。 第二，核心提供不容易通过临床获得的专业诊断服务， 实验室，并促进研究和开发新的诊断测试，最终转移到 临床实验室这些诊断服务与临床实验室检测紧密结合 在爱荷华州大学病理学系进行。核心B和 病理学服务为在爱荷华州大学就诊的患者提供最先进的诊断检测 医院和诊所，以及来自美国各地和其他几个州的爱荷华州的患者 国家该基础设施为神经肌肉疾病的临床试验提供了关键支持。

CORE B SUMMARY The Muscle Tissue/Cell Culture/Diagnostics Core of the Iowa Wellstone Muscular Dystrophy Cooperative Research Center is a multifaceted laboratory that serves as a local, national and international resource for research on muscular dystrophy and other neuromuscular diseases. This Core has two major goals. Firstly, it has established and will expand a tissue and cell culture Repository to support basic and translational research efforts. Currently, this Repository contains muscle biopsies from more than 8500 patients with neuromuscular disorders, as well as cryopreserved fibroblasts from more than 425 patients with myopathic disease, predominantly muscular dystrophies. Well-characterized tissues and cells from the Core are made available to research investigators at Iowa as well as other academic centers across the USA and around the world. Secondly, the Core provides specialty diagnostic services that are not readily available through clinical laboratories, and facilitates research on and the development of new diagnostic tests for eventual transfer into clinical laboratories. These diagnostic services are very closely integrated with clinical laboratory testing carried out in the Department of Pathology at the University of Iowa. Together, Core B and the Department of Pathology services provide state-of-the-art diagnostic testing for patients seen at the University of Iowa Hospitals and Clinics, and for patients referred to Iowa from throughout the USA and from several other countries. This infrastructure provides key support for clinical trials of neuromuscular disease.