Core B: The Muscle Tissue/Cell Repository and Specialty Diagnostics Core

核心B摘要 爱荷华州韦尔斯通肌肉营养不良合作社的肌肉组织/细胞培养/诊断核心 研究中心是一个多方面的实验室，为当地、国家和国际提供资源 肌肉营养不良和其他神经肌肉疾病的研究。这个核心有两个主要目标。首先，它 已经建立并将扩展组织和细胞培养资源库，以支持基础和翻译研究 努力。目前，这个资料库包含8500多名神经肌肉疾病患者的肌肉活组织检查 以及来自425多名肌病患者的冷冻保存的成纤维细胞， 以肌肉营养不良为主。来自核心的特征良好的组织和细胞被提供给 爱荷华州以及美国和世界各地的其他学术中心的研究人员。 其次，核心提供临床上不容易获得的专业诊断服务 实验室，并促进研究和开发新的诊断测试，最终转移到 临床实验室。这些诊断服务与临床实验室检测紧密结合在一起。 这项研究是在爱荷华大学病理学系进行的。核心B和该部共同努力 病理服务为爱荷华大学的患者提供最先进的诊断测试 医院和诊所，以及从美国各地和其他几个国家转诊到爱荷华州的患者 国家。这一基础设施为神经肌肉疾病的临床试验提供了关键支持。

CORE B SUMMARY The Muscle Tissue/Cell Culture/Diagnostics Core of the Iowa Wellstone Muscular Dystrophy Cooperative Research Center is a multifaceted laboratory that serves as a local, national and international resource for research on muscular dystrophy and other neuromuscular diseases. This Core has two major goals. Firstly, it has established and will expand a tissue and cell culture Repository to support basic and translational research efforts. Currently, this Repository contains muscle biopsies from more than 8500 patients with neuromuscular disorders, as well as cryopreserved fibroblasts from more than 425 patients with myopathic disease, predominantly muscular dystrophies. Well-characterized tissues and cells from the Core are made available to research investigators at Iowa as well as other academic centers across the USA and around the world. Secondly, the Core provides specialty diagnostic services that are not readily available through clinical laboratories, and facilitates research on and the development of new diagnostic tests for eventual transfer into clinical laboratories. These diagnostic services are very closely integrated with clinical laboratory testing carried out in the Department of Pathology at the University of Iowa. Together, Core B and the Department of Pathology services provide state-of-the-art diagnostic testing for patients seen at the University of Iowa Hospitals and Clinics, and for patients referred to Iowa from throughout the USA and from several other countries. This infrastructure provides key support for clinical trials of neuromuscular disease.