Core B: The Muscle Tissue/Cell Repository and Specialty Diagnostics Core

核心 B：肌肉组织/细胞存储库和专业诊断核心

• 批准号: 10442634
• 负责人: STEVEN A MOORE
• 金额: $ 38.76万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-08 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10442634
• 关键词: Diagnostic; Muscle; Muscular Dystrophies; Research; cell repository; medical specialties

CORE B SUMMARY The Muscle Tissue/Cell Culture/Diagnostics Core of the Iowa Wellstone Muscular Dystrophy Cooperative Research Center is a multifaceted laboratory that serves as a local, national and international resource for research on muscular dystrophy and other neuromuscular diseases. This Core has two major goals. Firstly, it has established and will expand a tissue and cell culture Repository to support basic and translational research efforts. Currently, this Repository contains muscle biopsies from more than 8500 patients with neuromuscular disorders, as well as cryopreserved fibroblasts from more than 425 patients with myopathic disease, predominantly muscular dystrophies. Well-characterized tissues and cells from the Core are made available to research investigators at Iowa as well as other academic centers across the USA and around the world. Secondly, the Core provides specialty diagnostic services that are not readily available through clinical laboratories, and facilitates research on and the development of new diagnostic tests for eventual transfer into clinical laboratories. These diagnostic services are very closely integrated with clinical laboratory testing carried out in the Department of Pathology at the University of Iowa. Together, Core B and the Department of Pathology services provide state-of-the-art diagnostic testing for patients seen at the University of Iowa Hospitals and Clinics, and for patients referred to Iowa from throughout the USA and from several other countries. This infrastructure provides key support for clinical trials of neuromuscular disease.

核心B总结 爱荷华州 Wellstone 肌营养不良合作社的肌肉组织/细胞培养/诊断核心 研究中心是一个多方面的实验室，为地方、国家和国际的资源提供服务 肌营养不良症和其他神经肌肉疾病的研究。该核心有两个主要目标。首先，它 已建立并将扩大组织和细胞培养库以支持基础和转化研究 努力。目前，该存储库包含 8500 多名神经肌肉疾病患者的肌肉活检样本 疾病，以及来自超过 425 名肌病患者的冷冻成纤维细胞， 主要是肌营养不良症。来自核心的充分表征的组织和细胞可用于 爱荷华州以及美国和世界各地其他学术中心的研究人员。 其次，核心提供临床无法轻易获得的专业诊断服务 实验室，并促进新诊断测试的研究和开发，最终转移到 临床实验室。这些诊断服务与临床实验室测试紧密结合 在爱荷华大学病理学系进行。核心 B 和部门一起 病理学服务为爱荷华大学就诊的患者提供最先进的诊断测试 医院和诊所，以及从美国各地和其他几个国家转介到爱荷华州的患者 国家。该基础设施为神经肌肉疾病的临床试验提供了关键支持。