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Regulating fibrosis and muscle growth in the muscular dystrophies

Regulating fibrosis and muscle growth in the muscular dystrophies
调节肌营养不良症中的纤维化和肌肉生长
批准号:
9022569
负责人:
Elizabeth M McNally
金额:
$114.18万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-07-01 至 2016-06-30

项目摘要

项目成果

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中文摘要
翻译
描述(由申请人提供):肌营养不良是一种遗传性疾病,目前尚无治愈方法。肌营养不良症的最严重形式之一是杜氏肌营养不良症(DMD)。DMD和肢带型肌营养不良症的一个亚群共同具有肌营养不良蛋白复合物的破坏。破坏抗肌萎缩蛋白复合物导致脆弱的肌肉膜、肌纤维损失和肌肉纤维化或瘢痕形成。多种证据表明纤维化是肌营养不良病理学的驱动因素。我们假设纤维化提供了一个支架,促进不利的细胞因子谱,进一步损害肌肉。我们进一步假设,不利的细胞因子谱的主要成分是TGF β和相关的TGF β家族成员肌肉生长抑制素。TGF β和肌生长抑制素一起导致纤维化增加、肌肉质量和再生减少以及膜脆性加剧。因此,我们建议确定TGF β和肌肉生长抑制素通常被基质隔离并保持不可用于受体接合和信号传导的方式,并确定如何促进肌营养不良症中TGF β和肌肉生长抑制素的失活(项目1)。我们还将证明肌肉生长抑制素和相关分子的释放和加工所需的蛋白水解切割步骤,以及可溶性受体在治疗肌营养不良症中的有效程度(项目2)。我们还将依次评估由TGF β和肌生长抑制素触发的不同细胞内信号传导途径,并测试抑制这些途径是否改善肌营养不良症的肌肉功能和病理学(项目3)。三位已建立的研究人员(McNally,Lee和Molkentin)将领导这些项目,形成一个独特的团队,他们的综合专业知识将定义肌营养不良症治疗意图的TGF β/肌肉生长抑制素途径。三个核心将支持项目;核心A将整合我们三个机构的努力,以确保无缝协作和材料转移。核心B将在基因操作和治疗后提供肌营养不良症的组织病理学评估,核心C将进行体内功能分析并为核心B提供支持。
英文摘要
DESCRIPTION (provided by applicant): Muscular dystrophy is a genetic disease for which there is no cure. One of the most severe forms of muscular dystrophy is Duchenne Muscular Dystrophy (DMD). DMD and a subset of the limb girdle muscular dystrophies have in common disruption of the dystrophin protein complex. Disrupting the dystrophin complex lead to a fragile muscle membrane, loss of myofibers and replacement of the muscle with fibrosis or scarring. Multiple lines of evidence point to fibrosis is as a driver of muscular dystrophy pathology. We hypothesize that fibrosis provides a scaffold that promotes an unfavorable cytokine profile that further damages muscle. We further hypothesize that the primary components of the unfavorable cytokine profile are TGFp and the related TGFp family member myostatin. Together, TGFp and myostatin, lead to increased fibrosis, reduced muscle mass and regeneration, and aggravated membrane fragility. Therefore, we propose to determine the means by which TGFp and myostatin are normally sequestered by the matrix and held unavailable for receptor engagement and signaling and to determine how to promote inactivation of TGFp and myostatin in muscular dystrophy (Project 1). We will also demonstrate necessary proteolytic cleavage steps for release and processing of myostatin, and related molecules, and the degree to which soluble receptors can be effective in treating muscular dystrophy (Project 2). We will also sequentially assess the distinct intracellular signaling pathways that are triggered by TGFp and myostatin and test whether inhibiting these pathways improves muscle function and pathology in muscular dystrophy (Project 3). Three established investigators (McNally, Lee, and Molkentin) will lead these projects forming a distinctive team where their combined expertise will define the TGFp/myostatin pathway for therapeutic intent in muscular dystrophy. Three Cores will support the Projects; Core A will integrate the efforts at our three institutions to assure seamless collaboration and transfer of materials. Core B will provide histopathological assessment of muscular dystrophy after genetic manipulation and treatments, and Core C will perform functional analysis in vivo and provide support to Core B.
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会议论文
Bridging Basic and Translational Science in Cardiovascular Disease
Cardiomyopathy Genomes Project
New Frontiers in Cardiovascular Research and Therapy
Failed Regeneration in the Muscular Dystrophies: Inflammation, Fibrosis and Fat - Administrative Supplement
  • 批准号:
    10212504
  • 项目类别:
  • 资助金额:
    $40.39万
  • 财政年份:
    2020
  • 负责人:
    Elizabeth M McNally
  • 依托单位:
国内基金
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    2023
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  • 资助金额:
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  • 负责人:
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  • 资助金额:
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  • 负责人:
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  • 批准号:
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  • 项目类别:
    面上项目
  • 资助金额:
    49.00万元
  • 批准年份:
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  • 负责人:
    刘才智
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