The MyGoals for Healthy Aging Multi-Center Randomized Controlled Trial

MyGoals 健康老龄化多中心随机对照试验

• 批准号: 10446592
• 负责人: Daniel Walker Belsky
• 金额: $ 59.86万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10446592
• 关键词: Age; Aging; Algorithms; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Automobile Driving; Behavioral; Biological; Biological Aging; Biological Assay; Blood; Blood Glucose; Blood specimen; Brain; C-reactive protein; Caring; Cause of Death; Cessation of life; Chronic Disease; Cognition; Cognitive; Cognitive Science; Collaborations; Collection; Consultations; Control Groups; Crime; DNA Methylation; Data; Data Collection; Data Linkages; Data Set; Development; Diabetes Mellitus; Diet; Disadvantaged; Economics; Emotional; Employment; Executive Dysfunction; Exercise; Family; Foundations; Freezing; Funding; Future; Genes; Glycosylated hemoglobin A; Goals; Health; Health Food; Health Insurance; Health Status; Health behavior; Height; Homeostasis; Housing; Human; Human Resources; Incentives; Income; Individual; Intervention; Investigation; Laboratories; Lead; Link; Loneliness; Longevity; Maintenance; Measures; Medical; Memory; Mental Depression; Mental Health; Methodology; Methods; Moods; Motivation; National Institute on Aging; Neuraxis; Neurons; Obesity; Outcome; Outcome Assessment; Outcome Measure; Participant; Pathway interactions; Personal Satisfaction; Persons; Phase; Population; Poverty; Premature aging syndrome; Process; Psyche structure; Psychological Stress; Psychologist; Public Housing; Randomized; Randomized Controlled Trials; Records; Research; Resource Sharing; Risk; Services; Sleep; Social Functioning; Social Policies; Social outcome; Stress; Surveys; System; Testing; Time; Unemployment; United States Dept. of Health and Human Services; Weight; Work; age related; biobank; blood pressure regulation; body system; cohort; dementia risk; design; diet and exercise; disparity elimination; disparity reduction; economic outcome; electronic data; executive function; field study; follow-up; frailty; health disparity; health related quality of life; healthy aging; improved; innovation; interdisciplinary approach; intervention effect; loss of function; methylation pattern; minority investigator; mortality; novel; nutrition; physical conditioning; prevent; programs; randomized trial; relating to nervous system; research and development; social; social health determinants; success; treatment group; welfare; whole genome

Poverty is associated with harsh living conditions, few opportunities to exercise, and poor access to healthy food that collectively produce “wear and tear” on organ systems. Psychological stress increases the fragility of neurons in the central nervous system, potentially producing both the loss of function and volume in areas of the brain that are involved in maintaining homeostasis (e.g., blood glucose), planning tasks, executing tasks, motivation, and emotional control. Psychological stress and poor nutrition can accelerate the aging process, and may manifest as executive function deficits, diabetes, obesity, Alzheimer's disease/Alzheimer's disease- related dementias (AD/ADRD), and early death. The mechanisms by which poverty-associated stress accelerates aging are known, but there is no proven intervention to slow the rapid pace of aging among impoverished families. Anti-poverty programs are a logical point of intervention. An ongoing randomized-controlled trial (RCT), MyGoals for Employment Success, intervenes on both poverty using proven employment incentives and on executive function deficits using a field-tested coaching program. That study was designed to evaluate outcomes associated with executive function, economic well-being, and social functioning. To evaluate outcomes associated with aging, additional intervention time and follow up are needed because health outcomes tend to lag economic outcomes. The National Institute on Aging provided one year of funding for cohort maintenance and to re-design MyGoals for Employment Success into a healthy aging study with three years of intervention time, six years of follow up, and health, aging, and cognition measures. This re-design was done in collaboration with leading interdisciplinary experts using the Delphi method, a formalized process for understanding how to optimize measure selection and the timing of measure collection. With their input, we propose an innovative RCT that we call MyGoals for Healthy Aging. We will measure the effect of the intervention on psychological stress, diet, sleep, mood, loneliness, height, weight, executive function, blood sugar, high-sensitivity C-reactive protein, and gene methylation patterns. We will also store blood for future “freezer studies” that allow for more sophisticated measures of human aging. In addition, we will maintain an ongoing dataset linked to electronic data so that it is possible to measure outcomes beyond the time frame of the study, including future income and mortality by cause of death. Completion of these aims will provide foundational evidence on the ability of social policy to influence aging-related health outcomes; our ultimate goal is to test a novel intervention that might reduce or eliminate disparities in chronic diseases including AD/ADRD.

贫穷与恶劣的生活条件、很少有机会锻炼和难以获得健康保健有关