The MyGoals for Healthy Aging Multi-Center Randomized Controlled Trial

MyGoals 健康老龄化多中心随机对照试验

基本信息

项目摘要

Poverty is associated with harsh living conditions, few opportunities to exercise, and poor access to healthy food that collectively produce “wear and tear” on organ systems. Psychological stress increases the fragility of neurons in the central nervous system, potentially producing both the loss of function and volume in areas of the brain that are involved in maintaining homeostasis (e.g., blood glucose), planning tasks, executing tasks, motivation, and emotional control. Psychological stress and poor nutrition can accelerate the aging process, and may manifest as executive function deficits, diabetes, obesity, Alzheimer's disease/Alzheimer's disease- related dementias (AD/ADRD), and early death. The mechanisms by which poverty-associated stress accelerates aging are known, but there is no proven intervention to slow the rapid pace of aging among impoverished families. Anti-poverty programs are a logical point of intervention. An ongoing randomized-controlled trial (RCT), MyGoals for Employment Success, intervenes on both poverty using proven employment incentives and on executive function deficits using a field-tested coaching program. That study was designed to evaluate outcomes associated with executive function, economic well-being, and social functioning. To evaluate outcomes associated with aging, additional intervention time and follow up are needed because health outcomes tend to lag economic outcomes. The National Institute on Aging provided one year of funding for cohort maintenance and to re-design MyGoals for Employment Success into a healthy aging study with three years of intervention time, six years of follow up, and health, aging, and cognition measures. This re-design was done in collaboration with leading interdisciplinary experts using the Delphi method, a formalized process for understanding how to optimize measure selection and the timing of measure collection. With their input, we propose an innovative RCT that we call MyGoals for Healthy Aging. We will measure the effect of the intervention on psychological stress, diet, sleep, mood, loneliness, height, weight, executive function, blood sugar, high-sensitivity C-reactive protein, and gene methylation patterns. We will also store blood for future “freezer studies” that allow for more sophisticated measures of human aging. In addition, we will maintain an ongoing dataset linked to electronic data so that it is possible to measure outcomes beyond the time frame of the study, including future income and mortality by cause of death. Completion of these aims will provide foundational evidence on the ability of social policy to influence aging-related health outcomes; our ultimate goal is to test a novel intervention that might reduce or eliminate disparities in chronic diseases including AD/ADRD.
贫穷与恶劣的生活条件、很少有机会锻炼和难以获得健康保健有关

项目成果

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Daniel Walker Belsky其他文献

Daniel Walker Belsky的其他文献

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{{ truncateString('Daniel Walker Belsky', 18)}}的其他基金

The MyGoals for Healthy Aging Multi-Center Randomized Controlled Trial
MyGoals 健康老龄化多中心随机对照试验
  • 批准号:
    10677637
  • 财政年份:
    2022
  • 资助金额:
    $ 59.86万
  • 项目类别:
The MyGoals for Healthy Aging Multi-Center Randomized Controlled Trial
MyGoals 健康老龄化多中心随机对照试验
  • 批准号:
    10800917
  • 财政年份:
    2022
  • 资助金额:
    $ 59.86万
  • 项目类别:
Genetic analysis of the Dutch Hunger Winter Families Study to Boost Rigor and Robustness for Testing In-Utero Famine Effects on Aging-Related Health Conditions and Biological Aging
荷兰饥饿冬季家庭研究的遗传分析,以提高测试宫内饥荒对衰老相关健康状况和生物衰老影响的严谨性和稳健性
  • 批准号:
    10831121
  • 财政年份:
    2020
  • 资助金额:
    $ 59.86万
  • 项目类别:
Development of a DNA methylation data resource for exposome research on Alzheiemer's Disease and Related Dementias within the Dutch Hunger Winter Families Study
荷兰饥饿冬季家庭研究中开发用于阿尔茨海默病和相关痴呆症暴露组研究的 DNA 甲基化数据资源
  • 批准号:
    10661283
  • 财政年份:
    2020
  • 资助金额:
    $ 59.86万
  • 项目类别:
Genetic analysis of the Dutch Hunger Winter Families Study to Boost Rigor and Robustness for Testing In-Utero Famine Effects on Aging-Related Health Conditions and Biological Aging
荷兰饥饿冬季家庭研究的遗传分析,以提高测试宫内饥荒对衰老相关健康状况和生物衰老影响的严谨性和稳健性
  • 批准号:
    10159838
  • 财政年份:
    2020
  • 资助金额:
    $ 59.86万
  • 项目类别:
Genetic analysis of the Dutch Hunger Winter Families Study to Boost Rigor and Robustness for Testing In-Utero Famine Effects on Aging-Related Health Conditions and Biological Aging
荷兰饥饿冬季家庭研究的遗传分析,以提高测试宫内饥荒对衰老相关健康状况和生物衰老影响的严谨性和稳健性
  • 批准号:
    10626012
  • 财政年份:
    2020
  • 资助金额:
    $ 59.86万
  • 项目类别:
Genetic analysis of the Dutch Hunger Winter Families Study to Boost Rigor and Robustness for Testing In-Utero Famine Effects on Aging-Related Health Conditions and Biological Aging
荷兰饥饿冬季家庭研究的遗传分析,以提高测试宫内饥荒对衰老相关健康状况和生物衰老影响的严谨性和稳健性
  • 批准号:
    10410379
  • 财政年份:
    2020
  • 资助金额:
    $ 59.86万
  • 项目类别:
Genomic Analysis of the CALERIE Trial to Generate New Knowledge for Geroscience
CALERIE 试验的基因组分析,为老年科学产生新知识
  • 批准号:
    10378000
  • 财政年份:
    2019
  • 资助金额:
    $ 59.86万
  • 项目类别:
Genomic Analysis of the CALERIE Trial to Generate New Knowledge for Geroscience
CALERIE 试验的基因组分析,为老年科学产生新知识
  • 批准号:
    9973115
  • 财政年份:
    2019
  • 资助金额:
    $ 59.86万
  • 项目类别:
Genomic Analysis of the CALERIE Trial to Generate New Knowledge for Geroscience
CALERIE 试验的基因组分析,为老年科学产生新知识
  • 批准号:
    10612785
  • 财政年份:
    2019
  • 资助金额:
    $ 59.86万
  • 项目类别:

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