Developing novel animal cell lines and processes incoperating engineered caf1 to scale cultured meat protein manufacturing

开发新型动物细胞系和工艺，与工程化 caf1 相结合，以扩大培养肉蛋白生产规模

• 批准号: 10076199
• 金额: $ 31.65万
• 依托单位: UNICORN BIOTECHNOLOGIES LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10076199
• 关键词: Developing; novel; animal; cell; lines

World meat consumption has tripled since 1970 and will increase a further 76% by 2050, posing a significant sustainability challenge. Livestock farming contributes to 15% of human-made greenhouse gas (GHG) emissions, which further exacerbates climate change, environmental destruction, and infectious disease outbreaks. Cultivated meat (CM) is an approach that rather than utilising animal agriculture as a source of proteins for human consumption, uses cell-based technologies to grow protein in a slaughter-free way. CM requires fewer resources, including energy, land, and water, and generates fewer GHG emissions compared to traditional livestock farming. It also eliminates concerns related to animal welfare and excessive antibiotic use. The major barriers preventing this approach from entering the consumer market relate to a mixture of economic and technical barriers. For this technological approach to be realized three principle components are needed, cells, growth media, and machines. This project seeks to develop panels of cell lines (the starting basis of all cultivated meat, Unicorn Bio, Trading as Dragon Bio) that will be released for sale to cultivated meat R&D tool developers and commercial manufacturers. Furthermore, we seek to develop growth media additives (MarraBio) that, simultaneously, significantly extend the variety of cell types amenable to be manufactured at industrial scales and vastly reduce the cost of such production. Thereby enabling the industry to move towards techno-economic feasibility, as well as the mass manufacture and consumer market entry of such products

自1970年以来，世界肉类消费量增加了两倍，到2050年将进一步增加76%，这对可持续发展构成了重大挑战。畜牧业占人类温室气体排放量的15%，这进一步加剧了气候变化、环境破坏和传染病爆发。养殖肉类（CM）是一种方法，而不是利用动物农业作为人类消费的蛋白质来源，而是使用基于细胞的技术以免屠宰的方式生长蛋白质。与传统畜牧业相比，CM需要更少的资源，包括能源，土地和水，并产生更少的温室气体排放。它还消除了与动物福利和过度使用抗生素有关的担忧。阻碍这种方法进入消费市场的主要障碍涉及经济和技术障碍。为了实现这种技术方法，需要三个主要组成部分，细胞，生长培养基和机器。该项目旨在开发细胞系面板（所有培养肉的起始基础，Unicorn Bio，Trading as Dragon Bio），这些细胞系将被发布用于销售培养肉研发工具开发商和商业制造商。此外，我们寻求开发生长培养基添加剂（MarraBio），同时显着扩展适合工业规模生产的细胞类型的种类，并大大降低生产成本。从而使该行业能够走向技术经济可行性，以及这种产品的大规模制造和进入消费者市场