The role structural discrimination on depression, sleep, cardiovascular disease, and cognitive decline

项目摘要 本研究补充申请，以促进健康相关研究的多样性（PA-21-071） 提出了一项研究和职业发展计划，以发展巴黎阿德金斯-杰克逊博士的独立性 通过一项名为“结构性歧视对抑郁、睡眠、心血管疾病和 认知能力下降”的奖励期间10/1/21-9/30/23。家长补助金，“减少种族差距， 阿尔茨海默病和相关痴呆症：解决结构性歧视和复原力” （DP1AG069874）。父母补助金是一个连续的混合方法研究，以制定一个措施的结构 歧视，然后确定结构性歧视对认知下降的影响， 美国。该研究从黑人社区成员那里汲取了专业知识，以阐明黑人社区的9个领域是如何发展的。 结构性歧视影响黑人老年人的生活。这些领域包括（1）教育，（2） 就业，（3）医疗保健，（4）环境，（5）社区，（6）警务，（7）媒体和营销，（8） 公民，和（9）收入，信用和财富。拟议的补充研究是一项二次数据分析 研究结构性歧视对阿尔茨海默病（AD）- 相关的认知能力下降和共病，如抑郁症，睡眠剥夺和心血管疾病。 本研究将在两个大的家庭中测试父母奖的9个领域的结构性歧视措施的有效性。 老龄化数据集：国家健康与老龄化研究（NHATS）和健康与退休研究（HRS）。 此外，本研究还将评估九个结构性歧视领域对 先前建立的AD认知能力下降与抑郁症、睡眠剥夺和 心血管疾病拟议的多样性补充将大大有助于了解 结构性歧视对AD种族差异的作用 关于AD和一些已知的风险因素，并为开发K奖和出版物简介提供指导， 结构性辨别和认知。

PROJECT SUMMARY This application for a Research Supplement to Promote Diversity in Health-Related Research (PA-21-071) proposes a research and career development plan to develop the independence of Dr. Paris Adkins-Jackson through a study titled, “The role of structural discrimination on depression, sleep, cardiovascular disease, and cognitive decline” for the award period of 10/1/21-9/30/23. The parent grant, “Reducing racial disparities in Alzheimer’s Disease and related dementias: Addressing structural discrimination and resilience” (DP1AG069874). The parent grant is a sequential mixed methods study to develop a measure of structural discrimination and then determine the influence of structural discrimination on cognitive decline in the United States (US). The study draws expertise from Black community members to elucidate how 9 domains of structural discrimination impact the lives of Black older adults. These domains include (1) education, (2) employment, (3) healthcare, (4) environment, (5) neighborhoods, (6) policing, (7) media and marketing, (8) civics, and (9) income, credit, and wealth. The proposed supplement study is a secondary data analysis examining the influence of structural discrimination on known relationships between Alzheimer’s disease (AD)- related cognitive decline and co-morbidities like depression, sleep deprivation, and cardiovascular disease. This study will test the validity of the parent award’s 9-domain measure of structural discrimination in two large aging datasets: National Health and Aging Study (NHATS) and Health and Retirement Study (HRS). Additionally, this study will estimate the influence of the nine domains of structural discrimination on the previously established relationships of AD-cognitive decline with depression, sleep deprivation, and cardiovascular disease. The proposed diversity supplement will significantly contribute to the understanding of the role of structural discrimination on AD racial disparities by delineating the effect of structural discrimination on AD and a few known risk factors and provide mentorship for developing a K award and publication profile in structural discrimination and cognition.