The role structural discrimination on depression, sleep, cardiovascular disease, and cognitive decline

项目总结 本申请书旨在促进健康相关研究的多样性(PA-21-071) 提出研究和职业发展计划，以发展帕丽斯·阿德金斯-杰克逊博士的独立性 通过一项名为“结构性歧视对抑郁、睡眠、心血管疾病和 10/1/21-9/30/23获奖期的“认知能力下降”。家长拨款：“减少种族差距 阿尔茨海默病和相关痴呆症：解决结构性歧视和复原力“ (DP1AG069874)。家长赠款是一项顺序混合方法研究，旨在开发一种结构性的措施 然后确定结构性歧视对美国认知衰退的影响 州(美国)。这项研究借鉴了黑人社区成员的专业知识，以阐明9个领域是如何 结构性歧视影响着黑人老年人的生活。这些领域包括(1)教育，(2) 就业，(3)医疗保健，(4)环境，(5)社区，(6)治安，(7)媒体和营销，(8) 公民教育，以及(9)收入、信贷和财富。拟议的补充研究是次要数据分析 研究结构性歧视对阿尔茨海默病(AD)之间已知关系的影响 相关的认知功能减退以及抑郁、睡眠不足和心血管疾病等并存疾病。 这项研究将检验父母奖的结构性歧视的9个领域测量在两个大的 老龄化数据集：国家健康与老龄化研究(NHATS)和健康与退休研究(HRS)。 此外，本研究将估计结构歧视的九个领域对结构歧视的影响 先前建立的AD认知功能下降与抑郁、睡眠剥夺和 心血管疾病。拟议的多样性补编将大大有助于理解 结构性歧视对阿尔茨海默病种族差异的作用 关于AD和一些已知的风险因素，并为制定K奖项和出版物简介提供指导 结构性歧视和认知。

PROJECT SUMMARY This application for a Research Supplement to Promote Diversity in Health-Related Research (PA-21-071) proposes a research and career development plan to develop the independence of Dr. Paris Adkins-Jackson through a study titled, “The role of structural discrimination on depression, sleep, cardiovascular disease, and cognitive decline” for the award period of 10/1/21-9/30/23. The parent grant, “Reducing racial disparities in Alzheimer’s Disease and related dementias: Addressing structural discrimination and resilience” (DP1AG069874). The parent grant is a sequential mixed methods study to develop a measure of structural discrimination and then determine the influence of structural discrimination on cognitive decline in the United States (US). The study draws expertise from Black community members to elucidate how 9 domains of structural discrimination impact the lives of Black older adults. These domains include (1) education, (2) employment, (3) healthcare, (4) environment, (5) neighborhoods, (6) policing, (7) media and marketing, (8) civics, and (9) income, credit, and wealth. The proposed supplement study is a secondary data analysis examining the influence of structural discrimination on known relationships between Alzheimer’s disease (AD)- related cognitive decline and co-morbidities like depression, sleep deprivation, and cardiovascular disease. This study will test the validity of the parent award’s 9-domain measure of structural discrimination in two large aging datasets: National Health and Aging Study (NHATS) and Health and Retirement Study (HRS). Additionally, this study will estimate the influence of the nine domains of structural discrimination on the previously established relationships of AD-cognitive decline with depression, sleep deprivation, and cardiovascular disease. The proposed diversity supplement will significantly contribute to the understanding of the role of structural discrimination on AD racial disparities by delineating the effect of structural discrimination on AD and a few known risk factors and provide mentorship for developing a K award and publication profile in structural discrimination and cognition.