Linking Disease Mechanisms and Outcomes in Rheumatic Diseases

将风湿性疾病的疾病机制和结果联系起来

• 批准号: 10447037
• 负责人: Joanne Michelle Kahlenberg
• 金额: $ 13.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-06 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10447037
• 关键词: Arthritis; Autoimmune; Award; B-Lymphocytes; Biology; Biometry; Biopsy; Cells; Chronic; Clinical; Clinical Trials; Clinical Trials Design; Collaborations; Complication; Data; Data Set; Development; Disease; Ensure; Environment; Fatigue; Fibroblasts; Fibromyalgia; Fostering; Functional disorder; Funding; Future; Genotype; Goals; Immune; Immunophenotyping; In Vitro; Inflammation; Inflammatory; Inflammatory Response; Infrastructure; Institutes; Interferons; Joints; Lesion; Link; Lupus; Maps; Measures; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Mission; Monitor; Mupirocin; Outcome; Pain; Pain Research; Pathogenesis; Patients; Pharmaceutical Preparations; Phenotype; Physicians; Population; Prediction of Response to Therapy; Production; Psoriasis; Psoriatic Arthritis; Public Health; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Rheumatism; Rheumatology; Science; Scientist; Secure; Sensory; Signal Transduction; Skin; Staphylococcus aureus; Systemic Lupus Erythematosus; T-Lymphocyte; Time; Topical application; Training Programs; Translational Research; Ultraviolet B Radiation; United States National Institutes of Health; Work; autocrine; base; biomarker discovery; career; chemokine; chronic pain; chronic widespread pain; clinical development; cohort; disease phenotype; faculty research; improved; in vivo; indexing; innovation; keratinocyte; large scale data; lupus cutaneous; meetings; microbial; microbial colonization; monocyte; mouse model; next generation; novel; pain sensitivity; patient oriented research; patient subsets; personalized medicine; programs; promoter; response; skills; skin disorder; tool; training opportunity; translational research program; treatment response

PROJECT SUMMARY/ABSTRACT Mentorship has been identified as a critical facilitator for development of clinical research faculty. This K24 application seeks to provide protected time for the applicant to continue to mentor numerous trainees in patient- oriented research (POR) and to grow her current program in new directions to further expand opportunities to mentor in this arena. 30% of the applicant's effort will be protected by this award for these activities. The applicant has demonstrated significant abilities in mentoring trainees at all career stages and will continue to benefit from the rich and robust institutional environment that provides stellar research infrastructure and a large pool of patients and mentees to work with. During the funding period, further development of the applicant will include 1) Improvement in mentorship skills in POR; 2) Enhancement of biostatistics for POR; and 3) Construction of a collaborative niche for POR in pain in rheumatic disease. These skillsets will be achieved through a combination of seminars, meetings, courses, and collaboration with the U of M Chronic Pain and Fatigue Research Center and the U of M Fibromyalgia Center of Research Translation (CORT). In addition, these skillsets will integrate and grow through continued mentorship of trainees within currently funded POR and through expansion into pain research through the K24 mechanism. These research opportunities include: work that examines the biology of lupus skin in the context of patient presentation and disease phenotype (Project 1); A clinical trial examining the impact of microbial colonization on lupus skin inflammation (Project 2); A large, novel immunophenotyped cohort of lupus and psoriasis/psoriatic arthritis patients that provides large scale datasets for analysis and clinical correlation (Project 3) and; A new dataset collected to longitudinally map chronic pain and sensory sensitivity in patients with systemic lupus (Project 4). Successful completion of this award will result in successful mentoring of current and future mentees in POR and also enlarge the POR program of the applicant to ensure continued mentoring opportunities into the future.

项目概要/摘要 导师制已被认为是临床研究人员发展的关键促进因素。这个K24 申请旨在为申请人提供受保护的时间，以继续指导众多患者的实习生 定向研究（POR），并将她当前的项目向新的方向发展，以进一步扩大机会 这个领域的导师。申请人在这些活动中 30% 的努力将受到该奖项的保护。申请人 在指导各个职业阶段的学员方面表现出了卓越的能力，并将继续受益于 丰富而强大的制度环境，提供一流的研究基础设施和大量的人才 与患者和受训者一起工作。 在资助期间，申请人的进一步发展将包括1）指导技能的提高 在 POR 中； 2）加强POR的生物统计； 3) 构建疼痛中 POR 的协作利基 在风湿性疾病中。这些技能将通过研讨会、会议、课程、 以及与密歇根大学慢性疼痛和疲劳研究中心以及密歇根大学纤维肌痛中心的合作 研究翻译（CORT）。此外，这些技能将通过持续的整合和发展 在目前资助的 POR 中对学员进行指导，并通过 K24 扩展到疼痛研究 机制。这些研究机会包括： 在背景下检查狼疮皮肤生物学的工作 患者表现和疾病表型（项目 1）；一项检验微生物影响的临床试验 狼疮皮肤炎症的定植（项目 2）；一个大型的、新型的狼疮和免疫表型队列 银屑病/银屑病关节炎患者提供大规模数据集用于分析和临床相关性（项目 3) 和;收集的新数据集用于纵向绘制患有以下疾病的患者的慢性疼痛和感觉敏感性 系统性狼疮（项目 4）。成功完成该奖项将导致成功指导当前和 未来的 POR 受训者，并扩大申请人的 POR 计划，以确保持续指导 未来的机会。