Linking Disease Mechanisms and Outcomes in Rheumatic Diseases

项目摘要/摘要 导师制已被确定为临床研究人员发展的关键促进者。这个K24 申请旨在为申请者提供受保护的时间，以便继续指导患者中的众多受训人员- 面向研究(POR)，并在新的方向上发展她目前的计划，以进一步扩大机会 这一领域的良师益友。申请者30%的努力将因这些活动而受到本奖项的保护。申请人 在指导学员的所有职业阶段都表现出了卓越的能力，并将继续受益于 丰富而稳健的制度环境提供了一流的研究基础设施和大量的 要与之共事的患者和受训者。 在资助期内，申请者的进一步发展将包括：1)提高指导技能 在POR中；2)增强POR的生物统计学；以及3)构建POR在疼痛中的协作生态位 在风湿病中。这些技能将通过研讨会、会议、课程、 并与密歇根大学慢性疼痛和疲劳研究中心和密歇根大学纤维肌痛中心合作 研究翻译部(CORT)。此外，这些技能组合将通过持续不断的 在目前资助的POR内指导受训人员，并通过K24扩展到疼痛研究 机制。这些研究机会包括：在背景下检查狼疮皮肤生物学的工作 患者表现和疾病表型(项目1)；一项检查微生物影响的临床试验 狼疮皮肤炎的定植(项目2)：一个大型的、新的免疫表型狼疮和红斑狼疮 牛皮癣/牛皮癣关节炎患者，为分析和临床相关性提供大规模数据集(项目 3)和；收集了一个新的数据集，以纵向描绘慢性疼痛和感觉敏感性的患者 系统性红斑狼疮(项目4)。成功完成此奖项将导致成功指导当前和 未来的POR指导对象，并扩大申请者的POR计划，以确保持续指导 走向未来的机遇。

PROJECT SUMMARY/ABSTRACT Mentorship has been identified as a critical facilitator for development of clinical research faculty. This K24 application seeks to provide protected time for the applicant to continue to mentor numerous trainees in patient- oriented research (POR) and to grow her current program in new directions to further expand opportunities to mentor in this arena. 30% of the applicant's effort will be protected by this award for these activities. The applicant has demonstrated significant abilities in mentoring trainees at all career stages and will continue to benefit from the rich and robust institutional environment that provides stellar research infrastructure and a large pool of patients and mentees to work with. During the funding period, further development of the applicant will include 1) Improvement in mentorship skills in POR; 2) Enhancement of biostatistics for POR; and 3) Construction of a collaborative niche for POR in pain in rheumatic disease. These skillsets will be achieved through a combination of seminars, meetings, courses, and collaboration with the U of M Chronic Pain and Fatigue Research Center and the U of M Fibromyalgia Center of Research Translation (CORT). In addition, these skillsets will integrate and grow through continued mentorship of trainees within currently funded POR and through expansion into pain research through the K24 mechanism. These research opportunities include: work that examines the biology of lupus skin in the context of patient presentation and disease phenotype (Project 1); A clinical trial examining the impact of microbial colonization on lupus skin inflammation (Project 2); A large, novel immunophenotyped cohort of lupus and psoriasis/psoriatic arthritis patients that provides large scale datasets for analysis and clinical correlation (Project 3) and; A new dataset collected to longitudinally map chronic pain and sensory sensitivity in patients with systemic lupus (Project 4). Successful completion of this award will result in successful mentoring of current and future mentees in POR and also enlarge the POR program of the applicant to ensure continued mentoring opportunities into the future.