Linking Disease Mechanisms and Outcomes in Rheumatic Diseases
将风湿性疾病的疾病机制和结果联系起来
基本信息
- 批准号:10447037
- 负责人:
- 金额:$ 13.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-06 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:ArthritisAutoimmuneAwardB-LymphocytesBiologyBiometryBiopsyCellsChronicClinicalClinical TrialsClinical Trials DesignCollaborationsComplicationDataData SetDevelopmentDiseaseEnsureEnvironmentFatigueFibroblastsFibromyalgiaFosteringFunctional disorderFundingFutureGenotypeGoalsImmuneImmunophenotypingIn VitroInflammationInflammatoryInflammatory ResponseInfrastructureInstitutesInterferonsJointsLesionLinkLupusMapsMeasuresMentorsMentorshipMid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented ResearchMissionMonitorMupirocinOutcomePainPain ResearchPathogenesisPatientsPharmaceutical PreparationsPhenotypePhysiciansPopulationPrediction of Response to TherapyProductionPsoriasisPsoriatic ArthritisPublic HealthRegulationResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResearch SupportResearch TrainingRheumatismRheumatologyScienceScientistSecureSensorySignal TransductionSkinStaphylococcus aureusSystemic Lupus ErythematosusT-LymphocyteTimeTopical applicationTraining ProgramsTranslational ResearchUltraviolet B RadiationUnited States National Institutes of HealthWorkautocrinebasebiomarker discoverycareerchemokinechronic painchronic widespread painclinical developmentcohortdisease phenotypefaculty researchimprovedin vivoindexinginnovationkeratinocytelarge scale datalupus cutaneousmeetingsmicrobialmicrobial colonizationmonocytemouse modelnext generationnovelpain sensitivitypatient oriented researchpatient subsetspersonalized medicineprogramspromoterresponseskillsskin disordertooltraining opportunitytranslational research programtreatment response
项目摘要
PROJECT SUMMARY/ABSTRACT
Mentorship has been identified as a critical facilitator for development of clinical research faculty. This K24
application seeks to provide protected time for the applicant to continue to mentor numerous trainees in patient-
oriented research (POR) and to grow her current program in new directions to further expand opportunities to
mentor in this arena. 30% of the applicant's effort will be protected by this award for these activities. The applicant
has demonstrated significant abilities in mentoring trainees at all career stages and will continue to benefit from
the rich and robust institutional environment that provides stellar research infrastructure and a large pool of
patients and mentees to work with.
During the funding period, further development of the applicant will include 1) Improvement in mentorship skills
in POR; 2) Enhancement of biostatistics for POR; and 3) Construction of a collaborative niche for POR in pain
in rheumatic disease. These skillsets will be achieved through a combination of seminars, meetings, courses,
and collaboration with the U of M Chronic Pain and Fatigue Research Center and the U of M Fibromyalgia Center
of Research Translation (CORT). In addition, these skillsets will integrate and grow through continued
mentorship of trainees within currently funded POR and through expansion into pain research through the K24
mechanism. These research opportunities include: work that examines the biology of lupus skin in the context
of patient presentation and disease phenotype (Project 1); A clinical trial examining the impact of microbial
colonization on lupus skin inflammation (Project 2); A large, novel immunophenotyped cohort of lupus and
psoriasis/psoriatic arthritis patients that provides large scale datasets for analysis and clinical correlation (Project
3) and; A new dataset collected to longitudinally map chronic pain and sensory sensitivity in patients with
systemic lupus (Project 4). Successful completion of this award will result in successful mentoring of current and
future mentees in POR and also enlarge the POR program of the applicant to ensure continued mentoring
opportunities into the future.
项目总结/摘要
导师制已被确定为临床研究教师发展的关键促进者。K24
申请旨在为申请人提供受保护的时间,以继续指导众多的学员,
面向研究(POR),并在新的方向发展她目前的计划,以进一步扩大机会,
这个竞技场的导师申请人30%的努力将受到该奖项的保护。申请人
在指导学员的各个职业阶段都表现出了显著的能力,并将继续受益于
丰富和强大的机构环境,提供一流的研究基础设施和大量的
患者和学员一起工作。
在资助期间,申请人的进一步发展将包括:1)提高导师技能
2)增强POR的生物统计学; 3)构建POR疼痛的协作生态位
在风湿性疾病中。这些技能将通过研讨会,会议,课程,
并与密歇根大学慢性疼痛和疲劳研究中心和密歇根大学纤维肌痛中心合作
研究翻译(CORT)此外,这些技能将通过持续的整合和发展
在目前资助的POR内指导受训人员,并通过K24扩展到疼痛研究
机制这些研究机会包括:研究狼疮皮肤的生物学
患者表现和疾病表型(项目1);一项临床试验,检查微生物
狼疮皮肤炎症的定植(项目2);一个大型的,新的狼疮免疫表型队列,
银屑病/银屑病关节炎患者提供大规模数据集用于分析和临床相关性(项目
3)和;收集了一个新的数据集,以纵向绘制慢性疼痛和感觉敏感性患者,
系统性狼疮(项目4)。成功完成此奖项将导致成功的指导目前和
在POR中的未来学员,并扩大申请人的POR计划,以确保持续的指导
未来的机遇。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Joanne Michelle Kahlenberg其他文献
Joanne Michelle Kahlenberg的其他文献
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{{ truncateString('Joanne Michelle Kahlenberg', 18)}}的其他基金
Hippo signaling as a critical regulator of lupus keratinocyte dysfunction
Hippo 信号作为狼疮角质形成细胞功能障碍的关键调节因子
- 批准号:
10675692 - 财政年份:2022
- 资助金额:
$ 13.5万 - 项目类别:
Hippo signaling as a critical regulator of lupus keratinocyte dysfunction
Hippo 信号作为狼疮角质形成细胞功能障碍的关键调节因子
- 批准号:
10536347 - 财政年份:2022
- 资助金额:
$ 13.5万 - 项目类别:
Linking Disease Mechanisms and Outcomes in Rheumatic Diseases
将风湿性疾病的疾病机制和结果联系起来
- 批准号:
10657643 - 财政年份:2020
- 资助金额:
$ 13.5万 - 项目类别:
Linking Disease Mechanisms and Outcomes in Rheumatic Diseases
将风湿性疾病的疾病机制和结果联系起来
- 批准号:
10210191 - 财政年份:2020
- 资助金额:
$ 13.5万 - 项目类别:
Characterization of Interferon Kappa as a Novel Target in Cutaneous Lupus
干扰素 Kappa 作为皮肤狼疮新靶点的表征
- 批准号:
9761987 - 财政年份:2017
- 资助金额:
$ 13.5万 - 项目类别:
Characterization of Interferon Kappa as a Novel Target in Cutaneous Lupus
干扰素 Kappa 作为皮肤狼疮新靶点的表征
- 批准号:
10238899 - 财政年份:2017
- 资助金额:
$ 13.5万 - 项目类别:
Characterization of Interferon Kappa as a Novel Target in Cutaneous Lupus
干扰素 Kappa 作为皮肤狼疮新靶点的表征
- 批准号:
10470213 - 财政年份:2017
- 资助金额:
$ 13.5万 - 项目类别:
Characterization of Interferon Kappa as a Novel Target in Cutaneous Lupus
干扰素 Kappa 作为皮肤狼疮新靶点的表征
- 批准号:
10004499 - 财政年份:2017
- 资助金额:
$ 13.5万 - 项目类别:
Identification of BATF2 as a Regulator of Interferon-Enhanced Inflammatory Responses in Lupus Skin
鉴定 BATF2 作为狼疮皮肤中干扰素增强炎症反应的调节剂
- 批准号:
9375222 - 财政年份:2017
- 资助金额:
$ 13.5万 - 项目类别:
Understanding transcriptional connections between cutaneous and systemic lupus
了解皮肤狼疮和系统性狼疮之间的转录联系
- 批准号:
8825016 - 财政年份:2014
- 资助金额:
$ 13.5万 - 项目类别:
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