Core D: Cardiometabolic Phenotyping Core

心脏代谢表型核心(核心D)。摘要： 心脏代谢性疾病表型核心(核心D)的总体目标是提供集中的专业知识 进行与心脏代谢性疾病相关的最先进的动物模型研究，以支持 此计划内的项目。这一核心对于建立小鼠表型研究的一致性是必要的 在所有三个项目中执行，并将确保无缝数据共享和比较每个项目如何 研究中不同肠道微生物代谢途径对小鼠心脏代谢性疾病的影响。全 这项PPG中的项目建议检查选定的肠道微生物衍生的代谢物对宿主的影响 心血管疾病的表型包括动脉粥样硬化、血栓形成、肥胖、胰岛素/血糖 动态平衡，改变脂质/胆汁酸代谢。这些表型中的每一个都需要独立的严谨 方法由每个领域训练有素的调查人员执行。心脏代谢性疾病 表型鉴定核心(核心D)将提供集中的老鼠表型鉴定服务方面的技术专长，这将 与所有其他研究项目和核心协作，以检查改变直觉的影响 微生物代谢产物对心脏代谢性疾病表型的影响。

Cardiometabolic Phenotyping Core (Core D). ABSTRACT: The overall goal of the Cardiometabolic Disease Phenotyping Core (Core D) is to provide centralized expertise for performance of state-of-the-art animal model studies relevant to Cardiometabolic Diseases in support of Projects within this Program. This core is necessary to establish consistency in mouse phenotyping studies performed across all three Projects, and will ensure seamless data sharing and comparison of how each of the different gut microbial metabolite pathways under investigation impact cardiometabolic disease in mice. All projects in this PPG propose to examine the impact of select gut microbe-derived metabolites on host cardiometbolic disease phenotypes including atherosclerosis, thrombosis, adiposity, insulin/glucose homeostasis, and altered lipid/bile acid metabolism. Each of these phenotypes requires independent rigorous methods to be carried out by well-trained investigators in each area. The Cardiometabolic Disease Phenotyping Core (Core D) will provide technical expertise in a centralized mouse phenotyping service that will collaboratively interface with all other research projects and cores to examine the effect of altering gut microbial metabolites on cardiometabolic disease phenotypes.