Core D: Cardiometabolic Phenotyping Core

核心 D：心脏代谢表型核心

• 批准号: 10206253
• 负责人: Jonathan Mark Brown
• 金额: $ 25.76万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10206253
• 关键词: Adipose tissue; Animal Model; Animal Sources; Animals; Area; Atherosclerosis; Bile Acids; Bioinformatics; Blood Platelets; Cardiometabolic Disease; Cells; Clinic; Clinical; Collaborations; Controlled Environment; Coupled; Development; Diet; Disease; Energy Metabolism; Engineering; Ensure; Formulation; Genotype; Germ; Germ-Free; Gnotobiotic; Goals; Human; Individual; Insulin; Investigation; Lesion; Lipids; Lipoproteins; Lyase; Mass Spectrum Analysis; Metabolic; Metabolism; Metagenomics; Methodology; Methods; Modeling; Mus; Obesity; Pathogenesis; Pathway interactions; Performance; Phenotype; Protocols documentation; Reagent; Research Personnel; Research Project Grants; Role; Sampling; Services; Standardization; Sterilization; Study models; Sulfate; System; Technical Expertise; Thrombosis; Tissues; Tracer; Training Support; Transplantation; Universities; Work; bile acid metabolism; blood glucose regulation; cardiometabolism; chemical synthesis; data sharing; design; disease phenotype; gut microbes; gut microbiota; in vivo; inhibitor/antagonist; insulin sensitivity; investigator training; metabolomics; microbial; microbial community; microbiome analysis; mouse model; novel strategies; pre-clinical; pressure; programs; seal; small molecule; stable isotope; trait; transcriptome sequencing; trimethylamine

Cardiometabolic Phenotyping Core (Core D). ABSTRACT: The overall goal of the Cardiometabolic Disease Phenotyping Core (Core D) is to provide centralized expertise for performance of state-of-the-art animal model studies relevant to Cardiometabolic Diseases in support of Projects within this Program. This core is necessary to establish consistency in mouse phenotyping studies performed across all three Projects, and will ensure seamless data sharing and comparison of how each of the different gut microbial metabolite pathways under investigation impact cardiometabolic disease in mice. All projects in this PPG propose to examine the impact of select gut microbe-derived metabolites on host cardiometbolic disease phenotypes including atherosclerosis, thrombosis, adiposity, insulin/glucose homeostasis, and altered lipid/bile acid metabolism. Each of these phenotypes requires independent rigorous methods to be carried out by well-trained investigators in each area. The Cardiometabolic Disease Phenotyping Core (Core D) will provide technical expertise in a centralized mouse phenotyping service that will collaboratively interface with all other research projects and cores to examine the effect of altering gut microbial metabolites on cardiometabolic disease phenotypes.

心脏代谢表型核心（Core D）。文摘: