Core D: Cardiometabolic Phenotyping Core

心脏代谢表型核心（核心D）。摘要： 心脏代谢疾病表型核心（核心D）的总体目标是提供集中的专业知识 进行与心脏代谢疾病相关的最先进动物模型研究，以支持 本计划内的项目。这一核心是必要的，以建立一致性，在小鼠表型研究 在所有三个项目中进行，并将确保无缝的数据共享和比较每个项目 研究中的不同肠道微生物代谢途径对小鼠心脏代谢疾病的影响。所有 本PPG中的项目建议检查选择的肠道微生物衍生代谢物对宿主的影响， 心脏代谢疾病表型，包括动脉粥样硬化、血栓形成、肥胖、胰岛素/葡萄糖 体内平衡以及脂质/胆汁酸代谢的改变。这些表型中的每一种都需要独立的严格的 每个地区训练有素的调查人员将采用各种方法。心脏代谢疾病 表型核心（核心D）将在集中的小鼠表型服务中提供技术专长， 与所有其他研究项目和核心协作，以检查改变肠道的影响 微生物代谢物对心脏代谢疾病表型的影响。

Cardiometabolic Phenotyping Core (Core D). ABSTRACT: The overall goal of the Cardiometabolic Disease Phenotyping Core (Core D) is to provide centralized expertise for performance of state-of-the-art animal model studies relevant to Cardiometabolic Diseases in support of Projects within this Program. This core is necessary to establish consistency in mouse phenotyping studies performed across all three Projects, and will ensure seamless data sharing and comparison of how each of the different gut microbial metabolite pathways under investigation impact cardiometabolic disease in mice. All projects in this PPG propose to examine the impact of select gut microbe-derived metabolites on host cardiometbolic disease phenotypes including atherosclerosis, thrombosis, adiposity, insulin/glucose homeostasis, and altered lipid/bile acid metabolism. Each of these phenotypes requires independent rigorous methods to be carried out by well-trained investigators in each area. The Cardiometabolic Disease Phenotyping Core (Core D) will provide technical expertise in a centralized mouse phenotyping service that will collaboratively interface with all other research projects and cores to examine the effect of altering gut microbial metabolites on cardiometabolic disease phenotypes.