权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Utilizing beige fat to improve muscle function after rotator cuff repair

利用米色脂肪改善肩袖修复后的肌肉功能

基本信息

批准号：
10447005
负责人：
Brian Feeley
金额：
$ 33.39万
依托单位：
NORTHERN CALIFORNIA INSTITUTE/RES/EDU
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10447005
关键词：
Adipocytes Adipose tissue Affect Age-Years American Animal Model Animals Anterior Atrophic Cell Differentiation process Cell physiology Cells Clinical Coculture Techniques Data Development Diabetes Mellitus Economic Burden FRAP1 gene Failure Fatty acid glycerol esters Follistatin Gene Expression Grant Growth Health Care Costs Human In Vitro Infiltration Injury Insulin-Like Growth Factor I Knowledge Link Metabolic Molecular Mus Muscle Muscle function Muscular Atrophy Myopathy Operative Surgical Procedures Outcome Outcome Study Pathway interactions Patient-Focused Outcomes Patients Pattern Pharmacological Treatment Pharmacology Phenotype Population Process Production Productivity Proliferating Quality of life Recovery Role Rotator Cuff Shoulder Pain Source Thermogenesis Transgenic Mice Translating Upper Extremity Wages Work adipokines age group aged cell type clinically significant clinically translatable disability experimental study gain of function gait examination human old age (65+)human tissue improved injured injury and repair interest limb injury loss of function medical attention mouse model muscle degeneration muscle regeneration novel overexpression physically handicapped progenitor repair model repaired rotator cuff injury rotator cuff tear satellite cell shoulder injury stem cell population stem cells success supraspinatus muscle surgery outcome therapeutic target treatment strategy

项目摘要

123 PROJECT DESCRIPTION 45 Rotator cuff (RC) tears are an extremely common cause of shoulder pain and disability. Up to 50% of patients greater than the age of 65 years of age have evidence 6789 of a RC tear. In addition, patients with small asymptomatic cuff tears tend to progress to larger, symptomatic tears. The outcomes of surgical repair of small RC tears are good, but there has been limited success in the surgical treatment of massive RC tears. 11 01 Massive RC tears have been linked with fatty infiltration of the rotator cuff muscles. Patients with large RC tears who develop fatty infiltration have poorer clinical outcomes 11 23 and higher rates of failure after attempted repair. We have previously found that a newly discovered stem cell population-fibro/adipocyte progenitor (FAP) cells-is critical in the 11 45 development of fatty infiltration after RC injury. Further, these cells share similar expression patterns with the beige adipocyte lineage, a distinct cell population that has 11 67 unique thermogenic and metabolic capabilities that could improve muscle function. 11 89 The study will leverage our well-studied animal model and a novel repair model to evaluate the mechanism by which FAP cells can improve muscle function through 22 01 differentiation into a beige fat phenotype in mouse and human tissue. Understanding the relationship between FAP cells and beige adipocytes and utilizing these cells in endogenous and exogenous treatment strategies could help improve muscle quality in RC repair as well as other muscle injury states.

123