权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Skeletal Phenotyping Core

骨骼表型核心

基本信息

批准号：
10451722
负责人：
MARY L BOUXSEIN
金额：
$ 28.16万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-19 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10451722
关键词：
Achievement Address Animals Applications Grants Architecture Area Award Biology Bone remodeling Clinical Clinical Investigator Collaborations Communities Consultations Core Facility Data Data Analyses Disease Education Educational process of instructing Educational workshop Ensure Evaluation Experimental Designs Fostering Genetic Goals Histology Human Individual Infrastructure Activities Institution Intervention Knowledge Mechanics Mentors Mentorship Methods Mission Molecular Morphology New England New York Pharmacology Phenotype Process Productivity Publications Quality Control Research Research Peer Review Research Personnel Research Project Grants Research Support Resource Sharing Services Specimen Specimen Handling Structure Sum Techniques Technology Therapeutic Time Training Training and Education Translating Update bone bone cell bone imaging bone mass career cost effective cost efficient design experience experimental study in vivo innovation interest member new technology novel peer support ranpirnase single-cell RNA sequencing skeletal skeletal disorder success synergism testing services

项目摘要

Identification of the structural, architectural, cellular and molecular basis for the skeletal phenotypes that result from genetic/pharmacologic interventions and disease states is essential for translating scientific discoveries into therapeutic innovations. The goal of the Skeletal Phenotyping Core is to provide cost-efficient, state of the art, quality-controlled skeletal phenotyping services, continuing to fulfill the unmet needs of early stage investigators who are transitioning to an independent career in skeletal biology, of established investigators who are new to skeletal biology and of established skeletal biologists. Key missions of the Skeletal Phenotyping Core include education, mentoring and incorporation of novel and innovative services to meet the needs of the constituent investigators. Consultation regarding experimental design, specimen handling and data analysis is provided by Core directors, to ensure that the maximal amount of data can be obtained from each specimen/subject. The Core will conduct didactic teaching sessions, hands-on workshops and seminars designed to educate investigators and to foster collaboration among investigators. A special focus of the Core will continue to be mentorship of early stage investigators and of those investigators new to skeletal biology. This infrastructure and these activities will continue to: 1) enhance the productivity and expand the scope of research being conducted by the Core investigators, 2) promote innovation and incorporation of novel technologies into core services, 3) foster synergy across a large and diverse community interested in skeletal research, ultimately leading to levels of success greater than the sum of the individual investigators’ projected achievements. These goals will be achieved by two specific aims: Aim 1) Provide efficient, high-quality, state- of-the-art skeletal phenotyping services that are not readily supported by individual research grants in a timely fashion; Aim 2) Provide training, and educational services to support new investigators in skeletal biology and to facilitate collaboration among core investigators. In summary, the Skeletal Phenotyping Core will continue to enhance the research productivity of a large and diverse community of investigators in skeletal biology by ensuring accurate, efficient and comprehensive analyses of skeletal phenotypes.

确定导致骨骼表型的结构、建筑、细胞和分子基础从遗传/药理学干预和疾病状态是必不可少的转化科学发现转化为治疗创新。Skeleton表型核心的目标是提供具有成本效益的，艺术，质量控制的骨骼表型服务，继续满足早期阶段未满足的需求正在过渡到骨骼生物学独立职业的研究者，已建立的研究者他们是骨骼生物学的新手，也是公认的骨骼生物学家。Skeleton的主要任务表型分析核心包括教育，指导和纳入新颖和创新的服务，以满足调查人员的需求。关于实验设计、样品处理和数据分析由核心主管提供，以确保可以从每个样本/受试者。该中心将举办教学课程、实践讲习班和研讨会旨在教育调查人员并促进调查人员之间的合作。核心的一个特别重点将继续指导早期研究者和那些刚接触骨骼生物学的研究者。这些基础设施和这些活动将继续：1）提高生产力，扩大核心研究者正在进行的研究，2）促进创新和新的 3）在对核心服务感兴趣的庞大而多样化的社区中促进协同作用，研究，最终导致的成功水平大于个人研究者的预测总和成绩这些目标将通过两个具体目标来实现：目标1）提供高效，高质量，状态- 最先进的骨骼表型分析服务，这些服务不容易及时得到个人研究赠款的支持。目标2）提供培训和教育服务，以支持骨骼生物学的新研究者，促进核心调查人员之间的合作。总之，Skeleton表型核心将继续通过以下方式提高骨骼生物学研究人员的大型和多样化社区的研究生产力确保骨骼表型的准确、高效和全面分析。