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Skeletal Phenotyping Core

骨骼表型核心

基本信息

批准号：
10626809
负责人：
MARY L BOUXSEIN
金额：
$ 28.16万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-19 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10626809
关键词：
Achievement Address Animals Applications Grants Architecture Area Award Biology Bone remodeling Clinical Clinical Investigator Collaborations Communities Consultations Core Facility Data Data Analyses Disease Education Educational process of instructing Educational workshop Ensure Evaluation Experimental Designs Fostering Genetic Goals Histology Human Individual Infrastructure Institution Intervention Knowledge Mechanics Mentors Mentorship Methods Mission Molecular Morphology New England New York Phenotype Process Productivity Publications Quality Control Research Research Peer Review Research Personnel Research Project Grants Research Support Resource Sharing Services Specimen Specimen Handling Structure Sum Techniques Technology Therapeutic Training Training and Education Translating Update bone bone cell bone imaging bone mass career cost effective cost efficient design experience experimental study in vivo innovation interest member new technology novel peer support pharmacologic single-cell RNA sequencing skeletal skeletal disorder success synergism testing services

项目摘要

Identification of the structural, architectural, cellular and molecular basis for the skeletal phenotypes that result from genetic/pharmacologic interventions and disease states is essential for translating scientific discoveries into therapeutic innovations. The goal of the Skeletal Phenotyping Core is to provide cost-efficient, state of the art, quality-controlled skeletal phenotyping services, continuing to fulfill the unmet needs of early stage investigators who are transitioning to an independent career in skeletal biology, of established investigators who are new to skeletal biology and of established skeletal biologists. Key missions of the Skeletal Phenotyping Core include education, mentoring and incorporation of novel and innovative services to meet the needs of the constituent investigators. Consultation regarding experimental design, specimen handling and data analysis is provided by Core directors, to ensure that the maximal amount of data can be obtained from each specimen/subject. The Core will conduct didactic teaching sessions, hands-on workshops and seminars designed to educate investigators and to foster collaboration among investigators. A special focus of the Core will continue to be mentorship of early stage investigators and of those investigators new to skeletal biology. This infrastructure and these activities will continue to: 1) enhance the productivity and expand the scope of research being conducted by the Core investigators, 2) promote innovation and incorporation of novel technologies into core services, 3) foster synergy across a large and diverse community interested in skeletal research, ultimately leading to levels of success greater than the sum of the individual investigators’ projected achievements. These goals will be achieved by two specific aims: Aim 1) Provide efficient, high-quality, state- of-the-art skeletal phenotyping services that are not readily supported by individual research grants in a timely fashion; Aim 2) Provide training, and educational services to support new investigators in skeletal biology and to facilitate collaboration among core investigators. In summary, the Skeletal Phenotyping Core will continue to enhance the research productivity of a large and diverse community of investigators in skeletal biology by ensuring accurate, efficient and comprehensive analyses of skeletal phenotypes.

鉴定导致的骨骼表型的结构、建筑、细胞和分子基础遗传/药物干预和疾病状态对于转化科学发现是必不可少的转化为治疗创新。骨骼表型核心的目标是提供具有成本效益的状态 ART，质量控制的骨骼表型鉴定服务，继续满足早期阶段未得到满足的需求正在过渡到骨骼生物学独立职业的研究人员，成熟的研究人员他们对骨骼生物学和老牌骨骼生物学家来说都是新手。骷髅的主要任务表型鉴定核心包括教育、指导以及纳入新的和创新的服务，以满足组成调查人员的需要。关于实验设计、标本处理和数据分析由Core Director提供，以确保可以从以下位置获取最大量的数据每个标本/受试者。中心将举办授课课程、实践工作坊和研讨会旨在教育调查人员并促进调查人员之间的合作。核心的特别关注点将继续指导早期研究人员和那些骨骼生物学新手的研究人员。这一基础设施和这些活动将继续：1)提高生产力并扩大核心研究人员正在进行的研究，2)促进小说的创新和融合将技术转化为核心服务，3)在对骨骼感兴趣的大型多样化社区中促进协同研究，最终导致的成功程度大于单个研究人员预测的总和成就。这些目标将通过两个具体目标实现：目标1)提供高效、高质量、国家-- 最先进的骨骼表型鉴定服务，没有及时得到个人研究拨款的支持目标2)提供培训和教育服务，以支持骨骼生物学和以促进核心调查人员之间的合作。总而言之，骨骼表型核心将继续通过以下方式提高骨骼生物学领域大型多样化研究人员的研究效率确保准确、高效和全面的骨骼表型分析。