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Skeletal Phenotyping Core

骨骼表型核心

基本信息

批准号：
10626809
负责人：
MARY L BOUXSEIN
金额：
$ 28.16万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-19 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10626809
关键词：
Achievement Address Animals Applications Grants Architecture Area Award Biology Bone remodeling Clinical Clinical Investigator Collaborations Communities Consultations Core Facility Data Data Analyses Disease Education Educational process of instructing Educational workshop Ensure Evaluation Experimental Designs Fostering Genetic Goals Histology Human Individual Infrastructure Institution Intervention Knowledge Mechanics Mentors Mentorship Methods Mission Molecular Morphology New England New York Phenotype Process Productivity Publications Quality Control Research Research Peer Review Research Personnel Research Project Grants Research Support Resource Sharing Services Specimen Specimen Handling Structure Sum Techniques Technology Therapeutic Training Training and Education Translating Update bone bone cell bone imaging bone mass career cost effective cost efficient design experience experimental study in vivo innovation interest member new technology novel peer support pharmacologic single-cell RNA sequencing skeletal skeletal disorder success synergism testing services

项目摘要

Identification of the structural, architectural, cellular and molecular basis for the skeletal phenotypes that result from genetic/pharmacologic interventions and disease states is essential for translating scientific discoveries into therapeutic innovations. The goal of the Skeletal Phenotyping Core is to provide cost-efficient, state of the art, quality-controlled skeletal phenotyping services, continuing to fulfill the unmet needs of early stage investigators who are transitioning to an independent career in skeletal biology, of established investigators who are new to skeletal biology and of established skeletal biologists. Key missions of the Skeletal Phenotyping Core include education, mentoring and incorporation of novel and innovative services to meet the needs of the constituent investigators. Consultation regarding experimental design, specimen handling and data analysis is provided by Core directors, to ensure that the maximal amount of data can be obtained from each specimen/subject. The Core will conduct didactic teaching sessions, hands-on workshops and seminars designed to educate investigators and to foster collaboration among investigators. A special focus of the Core will continue to be mentorship of early stage investigators and of those investigators new to skeletal biology. This infrastructure and these activities will continue to: 1) enhance the productivity and expand the scope of research being conducted by the Core investigators, 2) promote innovation and incorporation of novel technologies into core services, 3) foster synergy across a large and diverse community interested in skeletal research, ultimately leading to levels of success greater than the sum of the individual investigators’ projected achievements. These goals will be achieved by two specific aims: Aim 1) Provide efficient, high-quality, state- of-the-art skeletal phenotyping services that are not readily supported by individual research grants in a timely fashion; Aim 2) Provide training, and educational services to support new investigators in skeletal biology and to facilitate collaboration among core investigators. In summary, the Skeletal Phenotyping Core will continue to enhance the research productivity of a large and diverse community of investigators in skeletal biology by ensuring accurate, efficient and comprehensive analyses of skeletal phenotypes.

鉴定骨骼表型的结构、建筑、细胞和分子基础