West Virginia University Stroke COBRE

西弗吉尼亚大学中风 COBRE

• 批准号: 10451740
• 负责人: Elizabeth Engler-Chiurazzi
• 金额: $ 28.02万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-08 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10451740
• 关键词: Advisory Committees; Applications Grants; Area; Automation; Award; Behavior; Behavior assessment; Behavioral; Behavioral Assay; Biomedical Research; Brain; Brain Diseases; Centers of Research Excellence; Charge; Communities; Computer software; Consultations; Core Facility; Data; Data Collection; Educational workshop; Equipment; Evaluation; Experimental Designs; Faculty; Fees; Funding; Growth; Human; Instruction; Investments; Measures; Medical; Methods; Mission; Persons; Phase; Pre-Clinical Model; Procedures; Publications; Publishing; Quality Control; Quality of life; Recommendation; Reproducibility; Research; Research Infrastructure; Research Personnel; Resources; Rodent; Role; Schedule; Services; Shoulder; Statistical Data Interpretation; Stroke; Testing; Therapeutic Intervention; Training; Universities; Wages; West Virginia; Work; Writing; behavior test; comorbidity; cost; design; faculty support; functional outcomes; improved; instrumentation; journal article; nervous system disorder; novel therapeutic intervention; operation; post stroke; pre-clinical assessment; programs; recruit; stroke therapy; testing services; tool; university student

PROJECT SUMMARY Neurological disorders including stroke are highly prevalent and have substantial medical, financial, and human costs, including behavioral/functional disruptions that negatively impact quality of life. As such, the inclusion of functional assessments in studies of brain disorders is a necessary component of a high-profile, translational, and impactful biomedical research program. In this way, the West Virginia University (WVU) Rodent Behavior Core (RBC), a shared instrumentation facility dedicated to the assessment of functional outcomes in rodents, is a vital component of the WVU Stroke Center for Biomedical Research Excellence (WVU Stroke CoBRE). WVU RBC staff offer comprehensive behavioral testing services from ‘design to dissemination’ that include: consultation on experimental design and task selection, writing assistance, behavior testing training, conducting behavioral tests, maintaining RBC equipment, hardware and software, and data entry and statistical analysis assistance. To date, the RBC offers 27 distinct stroke-relevant tests comprising 5 domains of brain function that have enabled the facility and staff to support the work of 64 WVU investigators and trainees. This support has resulted in the submission of 58 internal and external grant proposals in which behavioral assays were proposed (18 of which have been funded). As well, 26 journal articles that utilized RBC services have been published. For Phase II of the WVU Stroke CoBRE, the RBC will 1) continue to provide high quality resources and operational support to the WVU Stroke CoBRE Junior Investigators, 2) implement new capabilities, facilities, and operation procedures to a productive core to support behavioral assessments, and 3) progress the RBC towards fiscal independence from the WVU Stroke CoBRE. Capitalizing on the successful implementation of the WVU RBC during the initial period, achieving these specific aims will enhance our ability to provide all necessary equipment, resources, and expertise to conduct rodent behavioral assessments to support WVU Stroke CoBRE-funded projects as well as other WVU investigators. This will enable the RBC to become a premiere facility for the assessment of rodent behavior, poise WVU to emerge as a center for excellence in the evaluation of stroke and its comorbidities, and support translational and collaborative research to enhance our understanding of neurological disorders and elucidating possible therapeutic interventions for the treatment of stroke and other brain disease.

项目摘要 包括中风在内的神经系统疾病是高度流行的，并且具有实质性的医疗、经济和人力资源。 成本，包括对生活质量产生负面影响的行为/功能中断。因此，包括 在大脑疾病的研究中，功能评估是一个高姿态的，翻译的， 有影响力的生物医学研究项目。通过这种方式，西弗吉尼亚大学（WVU）啮齿动物行为 核心（RBC），一个共享的仪器设施，专门用于评估啮齿动物的功能结果， WVU中风生物医学研究卓越中心（WVU Stroke CoBRE）的重要组成部分。WVU RBC员工提供从“设计到传播”的全面行为测试服务，包括： 实验设计和任务选择咨询，写作帮助，行为测试培训， 行为测试，维护RBC设备，硬件和软件，以及数据输入和统计分析 援助.迄今为止，RBC提供了27种不同的中风相关测试，包括5个脑功能领域， 使该设施和工作人员能够支持64名西弗吉尼亚大学调查员和受训人员的工作。这种支持 导致提交了58个内部和外部赠款提案，其中提出了行为分析 (18其中已获资助）。此外，还发表了26篇利用RBC服务的期刊文章。为 在西弗吉尼亚大学中风科博雷的第二阶段，红细胞将1）继续提供高质量的资源和运作 支持西弗吉尼亚大学中风科布雷初级研究者，2）实施新的能力、设施和操作 程序到一个生产性的核心，以支持行为评估，和3）进展的RBC对财政 独立于WVU Stroke CoBRE。充分利用WVU RBC的成功实施 在初期，实现这些具体目标将提高我们提供所有必要设备的能力， 资源和专业知识进行啮齿动物行为评估，以支持WVU中风CoBRE-funded 项目以及其他WVU调查员。这将使红细胞成为一个首映设施， 评估啮齿动物的行为，使西弗吉尼亚大学成为中风评估的卓越中心， 它的合并症，并支持转化和合作研究，以提高我们的理解， 神经系统疾病和阐明可能的治疗干预，用于治疗中风和其他 脑部疾病