A Mentoring Program in Kidney Care for Older Adults

老年人肾脏护理指导计划

• 批准号: 10449851
• 负责人: MANJULA KURELLA TAMURA
• 金额: $ 10.06万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10449851
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Address; Adult; Advance Care Planning; Affect; Age; Aging; Antihypertensive Agents; Area; Award; Benefits and Risks; Blood Pressure; Cardiovascular system; Caring; Cessation of life; Chronic Kidney Failure; Clinical Trials; Data; Decision Analysis; Dialysis procedure; Diastolic blood pressure; Discipline; Disease Management; Disease Progression; Education; Elderly; Electrolyte Disorder; Electronic Health Record; Event; Fostering; Frail Elderly; Funding; Future; Glucose; Goals; Grant; Guidelines; Health Services; Hypertension; Impaired cognition; Interdisciplinary Study; Intervention; Investigation; Journals; Kidney; Kidney Diseases; Knowledge; Mentors; Methodology; Methods; Midcareer Investigator Award in Patient-Oriented Research; Mineralocorticoid Receptor; Modeling; Nursing Homes; Organizational Policy; Outcome; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Policy Maker; Population; Positioning Attribute; Program Sustainability; Publishing; Pulse Pressure; Renal function; Renin-Angiotensin-Aldosterone System; Research; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Scientist; Serious Adverse Event; Shapes; Sodium; Structure; Study models; Systolic Pressure; Target Populations; Time; Training; Training Programs; United States Department of Veterans Affairs; Universities; Work; antagonist; base; cardiovascular risk factor; career; career development; clinical center; cohort; comparative; experience; hypertension treatment; inhibitor; mortality; multidisciplinary; next generation; novel; novel strategies; patient oriented; patient population; profiles in patients; programs; randomized trial; skills; tool; training opportunity; treatment effect

PROJECT SUMMARY/ABSTRACT This proposal for a Midcareer Investigator Award in Patient-Oriented Research (K24) will support the research program of Dr. Manjula Kurella Tamura, a nephrologist at Stanford University and Director of the Veterans Affairs Palo Alto Geriatric Research and Education Clinical Center. The candidate leads a multi-disciplinary research program which is focused on patient-centered outcomes of dialysis treatment in older adults. Her research program, comprised of a health services component and an interventions component, has been supported by five federally funded awards during the past five years, and has produced an extensive portfolio of work to support hypothesis driven mentee research. During this time, the candidate’s research program has provided training opportunities for 13 junior investigators who have successfully obtained funding, published research in high-impact journals, and transitioned into academic positions. In this K24 application, her overarching goal is to grow and sustain this program by: (1) enhancing her skills as a research mentor by obtaining training in key areas, and (2) using her research as a platform to mentor trainees from a range of disciplines, and (3) extending her research to evaluate treatment trade-offs earlier in the course of kidney disease. Recent clinical trials demonstrate that intensive versus standard blood pressure targets reduce mortality and cardiovascular events, but at the expense of kidney function. The scientific goal of this application is to evaluate the comparative harms and benefits of intensive versus standard hypertension treatment and hypertension deprescribing on kidney end-points in two real world older adult cohorts. The secondary goal is to demonstrate the application of novel analytical approaches that extend causal effects from randomized trials to older and sicker populations. The candidate’s mentoring program will integrate resources from the breadth of training programs at Stanford and VA Palo Alto, with unique opportunities tailored to the career development of scientists in aging research.

项目摘要/摘要 这项针对以患者为导向研究的中级研究员奖（K24）提出的建议将 支持斯坦福大学肾脏科医生Manjula Kurella Tamura博士的研究计划 大学和退伍军人事务主任帕洛阿尔托老年研究和教育 临床中心。候选人领导一项多学科研究计划，该计划的重点是 老年人中透析治疗的以患者为中心的结果。她的研究计划， 累积的健康服务组件和干预措施组成部分已经 在过去的五年中得到五项联邦资助奖的支持，并产生了 大量的工作组合以支持假设驱动研究。在此期间， 候选人的研究计划为13位初级调查人员提供了培训机会 成功获得了资金，在高影响期刊上发表了研究并过渡 进入学术职位。在此K24应用程序中，她的总体目标是增长和维持 程序作者：（1）通过在关键领域获得培训来提高她作为研究的技能， （2）将她的研究作为来自一系列学科的精神受训者的平台，以及（3） 扩展她的研究以评估肾脏疾病的早期治疗权衡。 最近的临床试验表明，密集与标准血压目标减少 死亡率和心血管事件，但以肾功能为代价。科学目标的 该应用是为了评估密集型与标准的比较危害和益处 在两个现实世界中的肾脏终点上的高血压治疗和高血压脱落 老年人队列。次要目标是证明新分析的应用 将因果关系从随机试验扩展到较老和病人的方法。 候选人的心理计划将从培训的广度中整合资源 斯坦福大学和弗吉尼亚州帕洛阿尔托的计划，为职业生涯量身定制的独特机会 衰老研究中的科学家的发展。