A Mentoring Program in Kidney Care for Older Adults

老年人肾脏护理指导计划

• 批准号: 10656289
• 负责人: MANJULA KURELLA TAMURA
• 金额: $ 13.76万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10656289
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Adult; Advance Care Planning; Affect; Age; Aging; Antihypertensive Agents; Area; Award; Benefits and Risks; Blood Pressure; Cardiovascular system; Caring; Cessation of life; Chronic Kidney Failure; Clinical Trials; Data; Decision Analysis; Dedications; Dialysis procedure; Diastolic blood pressure; Discipline; Disease Management; Disease Progression; Education; Elderly; Electrolyte Disorder; Electronic Health Record; Event; Fostering; Frail Elderly; Funding; Future; Glucose; Goals; Grant; Guidelines; Health Services; Hypertension; Impaired cognition; Interdisciplinary Study; Intervention; Investigation; Journals; Kidney; Kidney Diseases; Knowledge; Mentors; Methodology; Methods; Midcareer Investigator Award in Patient-Oriented Research; Mineralocorticoid Receptor; Modeling; Nursing Homes; Outcome; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Policies; Policy Maker; Population; Positioning Attribute; Program Sustainability; Publishing; Pulse Pressure; Recommendation; Renal function; Renin-Angiotensin-Aldosterone System; Research; Research Personnel; Research Project Grants; Research Support; Resources; Risk Reduction; Scientist; Serious Adverse Event; Shapes; Sodium; Structure; Study models; Systolic Pressure; Target Populations; Time; Training; Training Programs; United States Department of Veterans Affairs; Universities; Work; antagonist; cardiovascular risk factor; career; career development; clinical center; cohort; comparative; experience; hypertension treatment; inhibitor; mortality; multidisciplinary; next generation; novel; novel strategies; patient oriented; patient population; profiles in patients; programs; randomized trial; skills; symporter; tool; training opportunity; treatment effect

PROJECT SUMMARY/ABSTRACT This proposal for a Midcareer Investigator Award in Patient-Oriented Research (K24) will support the research program of Dr. Manjula Kurella Tamura, a nephrologist at Stanford University and Director of the Veterans Affairs Palo Alto Geriatric Research and Education Clinical Center. The candidate leads a multi-disciplinary research program which is focused on patient-centered outcomes of dialysis treatment in older adults. Her research program, comprised of a health services component and an interventions component, has been supported by five federally funded awards during the past five years, and has produced an extensive portfolio of work to support hypothesis driven mentee research. During this time, the candidate’s research program has provided training opportunities for 13 junior investigators who have successfully obtained funding, published research in high-impact journals, and transitioned into academic positions. In this K24 application, her overarching goal is to grow and sustain this program by: (1) enhancing her skills as a research mentor by obtaining training in key areas, and (2) using her research as a platform to mentor trainees from a range of disciplines, and (3) extending her research to evaluate treatment trade-offs earlier in the course of kidney disease. Recent clinical trials demonstrate that intensive versus standard blood pressure targets reduce mortality and cardiovascular events, but at the expense of kidney function. The scientific goal of this application is to evaluate the comparative harms and benefits of intensive versus standard hypertension treatment and hypertension deprescribing on kidney end-points in two real world older adult cohorts. The secondary goal is to demonstrate the application of novel analytical approaches that extend causal effects from randomized trials to older and sicker populations. The candidate’s mentoring program will integrate resources from the breadth of training programs at Stanford and VA Palo Alto, with unique opportunities tailored to the career development of scientists in aging research.

项目总结/文摘

项目成果

Estimated Effect of Parathyroidectomy on Long-Term Kidney Function in Adults With Primary Hyperparathyroidism.

甲状旁腺切除术对原发性甲状旁腺功能亢进症成人长期肾功能的估计影响。

• DOI: 10.7326/m22-2222
• 发表时间: 2023
• 期刊: Annals of internal medicine
• 影响因子: 39.2
• 作者: Seib,CarolynD;Ganesan,Calyani;Furst,Adam;Pao,AlanC;Chertow,GlennM;Leppert,JohnT;Suh,Insoo;Montez-Rath,MariaE;Harris,AlexHS;Trickey,AmberW;Kebebew,Electron;KurellaTamura,Manjula
• 通讯作者: KurellaTamura,Manjula