Clinical Translational Core

临床转化核心

• 批准号: 10450730
• 负责人: Leann Smith DaWalt
• 金额: $ 21.66万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10450730
• 关键词: Address; Adult; Area; Basic Science; Behavioral; Biomanufacturing; Biomedical Research; Blindness; COVID-19; Child; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Services; Clinical Trials; Clinical assessments; Communities; Community Practice; Consent; Consultations; Custom; Cyclic GMP; DNA; Data; Data Collection; Databases; Development; Developmental Disabilities; Diagnostic; Down Syndrome; Electronic Health Record; Enrollment; Equipment; Evaluation; Fragile X Syndrome; Future; Health; Health system; Hospitals; Human; Individual; Infant; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Intervention; Measurement; Modeling; Nursery Schools; Participant; Phenotype; Plasmids; Population; Process; Proteins; Recording of previous events; Registries; Research; Research Personnel; Research Proposals; Resources; Services; Specimen; Supervision; Technology; Therapeutic; Training; Translational Research; Translations; Traumatic Brain Injury; Universities; Video Recording; Virus; autism spectrum disorder; behavior test; biobank; biobehavior; cohort; computerized data processing; cost effective; design; disability; early childhood; experimental study; individuals with autism spectrum disorder; innovation; interest; laboratory equipment; method development; new technology; programs; psychologic; recruit; response; software development; therapy development; virtual; visual tracking

The Clinical Translational Core (CTC) promotes the use of, provides access to, and supports state-of-the-art technologies and resources to facilitate translation of basic science discoveries to the clinical setting, treatment development, clinical trials, and community practice. Indeed, the Waisman Center has always focused on clinical and translational research as one of the IDDRCs that contains a UCEDD (University Center of Excellence in Developmental Disabilities), including eleven diagnostic and treatment clinics operated in partnership with the two adjoining hospitals of the UW Health system and an inclusive model preschool program-the Waisman Early Childhood Program (WECP). Our history of interactions between research and clinical services continues to the present with studies of assessments, treatments, and interventions in conditions such as traumatic brain injury, blindness, Down syndrome, and autism spectrum disorder. Our Core incorporates new technologies and resources in biomedical research and serves as a focal point for cost- effective and innovative translational research related to intellectual and developmental disabilities (IDD) on our campus. The CTC has strong expertise in addressing challenges facing investigators who conduct behavioral and bio-behavioral research on IDD populations. Such populations present challenges to recruitment, require diagnostic evaluations by professionals with highly specialized training, and often involve assessment via innovative measurement strategies designed to focus specifically on the construct of interest and accessible to individuals with various types of disabilities; thus, linkages between basic, clinical and community applications of research in this area are critical. The CTC assists investigators with these and other challenges in the areas of recruitment, assessment, and behavioral methods development and applications. The CTC was dramatically enhanced within the last year by the development and implementation of a biobank to collect, store and make accessible for research biospecimens, clinical data, and health information from individuals with IDD. We have expanded our clinical research coordination and navigation services and we have upgraded our audio/video recording equipment for our behavioral testing suites. In response to COVID- 19, we have increased our clinical assessment and custom application services to support innovations needed for virtual data collection. Our specific aims for the next project period are to provide (1) support recruitment of human participants and provide access to data/specimens for behavioral, biobehavioral, and biomedical research and clinical trials, including capacity for cGMP biomanufacturing; (2) provide research coordination and navigation services; (3) provide specialized clinical assessments of individuals with IDD; and (4) provide behavioral methods development and custom applications.

临床翻译核心（CTC）促进了使用，提供并支持最先进的访问权限 促进基础科学发现转化为临床环境的技术和资源 发展，临床试验和社区实践。的确，怀斯曼中心一直集中在 临床和转化研究是包含UCEDD的IDDRC之一（大学中心 发育障碍的卓越表现），包括十个诊断和治疗诊所 与UW卫生系统的两家相邻医院和包容性模型学前班的合作关系 计划 - waisman幼儿计划（WECP）。我们研究与 临床服务继续进行目前的评估，治疗和干预措施的研究 诸如创伤性脑损伤，失明，唐氏综合症和自闭症谱系障碍等疾病。我们的核心 将新技术和资源纳入生物医学研究中，并成为成本的焦点 与智力和发展障碍有关的有效和创新的转化研究（IDD） 我们的校园。 CTC在应对进行调查人员面临的挑战方面具有强大的专业知识 对IDD人群的行为和生物行为研究。这样的人群面临 招聘，需要接受高度专业培训的专业人员进行诊断评估，并且经常涉及 通过创新的测量策略进行评估，旨在专门关注感兴趣的结构 并且有多种残疾的人可以使用；因此，基本，临床和 该领域的研究社区应用至关重要。 CTC协助调查人员和其他 招募，评估和行为方法的发展和应用方面的挑战。 通过生物库的开发和实施，CTC在过去一年内得到了巨大增强 收集，存储和使研究生物测量，临床数据和健康信息可访问 患有IDD的人。我们扩大了临床研究协调和导航服务，我们 为我们的行为测试套件升级了我们的音频/视频录制设备。响应于covid- 19，我们增加了临床评估和自定义申请服务，以支持所需的创新 用于虚拟数据收集。我们在下一个项目期间的具体目标是提供（1）支持招募 人类参与者并提供行为，生物行为和生物医学的数据/标本 研究和临床试验，包括CGMP生物制造的能力； （2）提供研究协调 和导航服务； （3）提供IDD患者的专门临床评估； （4）提供 行为方法开发和自定义应用程序。