Clinical Translational Core
临床转化核心
基本信息
- 批准号:10450730
- 负责人:
- 金额:$ 21.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-15 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAreaBasic ScienceBehavioralBiomanufacturingBiomedical ResearchBlindnessCOVID-19ChildClinicClinicalClinical DataClinical ResearchClinical ServicesClinical TrialsClinical assessmentsCommunitiesCommunity PracticeConsentConsultationsCustomCyclic GMPDNADataData CollectionDatabasesDevelopmentDevelopmental DisabilitiesDiagnosticDown SyndromeElectronic Health RecordEnrollmentEquipmentEvaluationFragile X SyndromeFutureHealthHealth systemHospitalsHumanIndividualInfantIntellectual and Developmental Disabilities Research CentersIntellectual functioning disabilityInterventionMeasurementModelingNursery SchoolsParticipantPhenotypePlasmidsPopulationProcessProteinsRecording of previous eventsRegistriesResearchResearch PersonnelResearch ProposalsResourcesServicesSpecimenSupervisionTechnologyTherapeuticTrainingTranslational ResearchTranslationsTraumatic Brain InjuryUniversitiesVideo RecordingVirusautism spectrum disorderbehavior testbiobankbiobehaviorcohortcomputerized data processingcost effectivedesigndisabilityearly childhoodexperimental studyindividuals with autism spectrum disorderinnovationinterestlaboratory equipmentmethod developmentnew technologyprogramspsychologicrecruitresponsesoftware developmenttherapy developmentvirtualvisual tracking
项目摘要
The Clinical Translational Core (CTC) promotes the use of, provides access to, and supports state-of-the-art
technologies and resources to facilitate translation of basic science discoveries to the clinical setting, treatment
development, clinical trials, and community practice. Indeed, the Waisman Center has always focused on
clinical and translational research as one of the IDDRCs that contains a UCEDD (University Center of
Excellence in Developmental Disabilities), including eleven diagnostic and treatment clinics operated in
partnership with the two adjoining hospitals of the UW Health system and an inclusive model preschool
program-the Waisman Early Childhood Program (WECP). Our history of interactions between research and
clinical services continues to the present with studies of assessments, treatments, and interventions in
conditions such as traumatic brain injury, blindness, Down syndrome, and autism spectrum disorder. Our Core
incorporates new technologies and resources in biomedical research and serves as a focal point for cost-
effective and innovative translational research related to intellectual and developmental disabilities (IDD) on
our campus. The CTC has strong expertise in addressing challenges facing investigators who conduct
behavioral and bio-behavioral research on IDD populations. Such populations present challenges to
recruitment, require diagnostic evaluations by professionals with highly specialized training, and often involve
assessment via innovative measurement strategies designed to focus specifically on the construct of interest
and accessible to individuals with various types of disabilities; thus, linkages between basic, clinical and
community applications of research in this area are critical. The CTC assists investigators with these and other
challenges in the areas of recruitment, assessment, and behavioral methods development and applications.
The CTC was dramatically enhanced within the last year by the development and implementation of a biobank
to collect, store and make accessible for research biospecimens, clinical data, and health information from
individuals with IDD. We have expanded our clinical research coordination and navigation services and we
have upgraded our audio/video recording equipment for our behavioral testing suites. In response to COVID-
19, we have increased our clinical assessment and custom application services to support innovations needed
for virtual data collection. Our specific aims for the next project period are to provide (1) support recruitment of
human participants and provide access to data/specimens for behavioral, biobehavioral, and biomedical
research and clinical trials, including capacity for cGMP biomanufacturing; (2) provide research coordination
and navigation services; (3) provide specialized clinical assessments of individuals with IDD; and (4) provide
behavioral methods development and custom applications.
临床翻译核心(CTC)促进使用、提供访问和支持最先进的技术
促进将基础科学发现转化为临床环境、治疗方法的技术和资源
开发、临床试验和社区实践。事实上,韦斯曼中心一直专注于
作为包含UCEDD(大学研究中心)的IDDRC之一的临床和翻译研究
发展障碍优秀),包括在#年运营的11个诊断和治疗诊所
与华盛顿大学卫生系统的两家毗邻医院和一所包容各方的模范学前班建立伙伴关系
计划-韦斯曼儿童早期计划(WECP)。我们的研究和研究之间相互作用的历史
临床服务持续到现在,通过评估、治疗和干预研究
如创伤性脑损伤、失明、唐氏综合症和自闭症谱系障碍。我们的核心
将新技术和资源纳入生物医学研究,并作为成本的焦点-
与智力和发育障碍(IDD)有关的有效和创新的翻译研究
我们的校园。反恐委员会在应对调查人员面临的挑战方面拥有强大的专业知识
碘缺乏病人群行为和生物行为研究。这些人口构成了对
招聘,需要经过高度专业化培训的专业人员进行诊断评估,而且往往涉及
通过创新的测量策略进行评估,旨在特别关注兴趣的构建
并为各种类型的残疾个人提供便利;因此,基础、临床和
这一领域的研究在社区中的应用至关重要。反恐委员会协助调查人员处理这些和其他
在招聘、评估和行为方法开发和应用方面的挑战。
去年开发和实施了一个生物库,大大加强了反恐委员会
收集、存储和提供生物标本、临床数据和健康信息以供研究使用
患有IDD的个体。我们已经扩大了我们的临床研究协调和导航服务,我们
已经为我们的行为测试套件升级了音频/视频记录设备。为了回应COVID-
19,我们增加了临床评估和定制应用程序服务,以支持所需的创新
用于虚拟数据收集。我们在下一个项目期的具体目标是:(1)支持招聘
人类参与者,并提供对行为、生物行为和生物医学数据/样本的访问
研究和临床试验,包括cGMP生物制造能力;(2)提供研究协调
和导航服务;(3)为IDD患者提供专门的临床评估;及(4)提供
行为方法开发和定制应用程序。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Leann Smith DaWalt其他文献
Age-related trajectories of health and cognition in mothers of children with developmental disabilities: Longitudinal findings from two independent studies
发育障碍儿童母亲的健康和认知的年龄相关轨迹:两项独立研究的纵向发现
- DOI:
10.1016/j.socscimed.2025.117912 - 发表时间:
2025-05-01 - 期刊:
- 影响因子:5.000
- 作者:
Robert S. Dembo;Jinkuk Hong;Leann Smith DaWalt;Marsha R. Mailick - 通讯作者:
Marsha R. Mailick
Exploring Parent and Autistic Youth Perspectives to Inform Adaptations for an Advocacy Program
- DOI:
10.1007/s10882-025-10005-z - 发表时间:
2025-01-29 - 期刊:
- 影响因子:1.500
- 作者:
Meghan M. Burke;Amanda N. Johnston;Saury Ramos-Torres;Sanskriti Singh;Leann Smith DaWalt;Julie Lounds Taylor - 通讯作者:
Julie Lounds Taylor
The Vocational and Educational Index: An Update to the Vocational Index to Reflect Contemporary Postsecondary Educational Options for Autistic Adults
- DOI:
10.1007/s10803-025-06737-8 - 发表时间:
2025-02-22 - 期刊:
- 影响因子:2.800
- 作者:
Julie Lounds Taylor;Sarah Roberts Carlson;Leann Smith DaWalt;Meghan M. Burke;Grace A. Herbert;Marsha R. Mailick - 通讯作者:
Marsha R. Mailick
Leann Smith DaWalt的其他文献
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{{ truncateString('Leann Smith DaWalt', 18)}}的其他基金
A Longitudinal Study of Employment and Educational Instability for Young Adults with Autism Spectrum Disorder
患有自闭症谱系障碍的年轻人就业和教育不稳定的纵向研究
- 批准号:
10200666 - 财政年份:2020
- 资助金额:
$ 21.66万 - 项目类别:
A Longitudinal Study of Employment and Educational Instability for Young Adults with Autism Spectrum Disorder
患有自闭症谱系障碍的年轻人就业和教育不稳定的纵向研究
- 批准号:
10640066 - 财政年份:2020
- 资助金额:
$ 21.66万 - 项目类别:
A Longitudinal Study of Employment and Educational Instability for Young Adults with Autism Spectrum Disorder
患有自闭症谱系障碍的年轻人就业和教育不稳定的纵向研究
- 批准号:
10400892 - 财政年份:2020
- 资助金额:
$ 21.66万 - 项目类别:
Women with Autism Spectrum Disorders during Adolescence and Adulthood: Unique and Common Vulnerabilities
青春期和成年期患有自闭症谱系障碍的女性:独特和常见的脆弱性
- 批准号:
9293774 - 财政年份:2017
- 资助金额:
$ 21.66万 - 项目类别:
Adults with Fragile X Syndrome: Health and Life Course Trajectories
患有脆性 X 综合症的成年人:健康和生命历程轨迹
- 批准号:
10736629 - 财政年份:2015
- 资助金额:
$ 21.66万 - 项目类别:
Multi-family Group Psychoeducation for Young Adults with ASD
针对患有自闭症谱系障碍的年轻人的多家庭团体心理教育
- 批准号:
9118786 - 财政年份:2014
- 资助金额:
$ 21.66万 - 项目类别:
Multi-family Group Psychoeducation for Young Adults with ASD
针对患有自闭症谱系障碍的年轻人的多家庭团体心理教育
- 批准号:
8755467 - 财政年份:2014
- 资助金额:
$ 21.66万 - 项目类别:
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