Clinical Translational Core

临床转化核心

• 批准号: 10450730
• 负责人: Leann Smith DaWalt
• 金额: $ 21.66万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10450730
• 关键词: Address; Adult; Area; Basic Science; Behavioral; Biomanufacturing; Biomedical Research; Blindness; COVID-19; Child; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Services; Clinical Trials; Clinical assessments; Communities; Community Practice; Consent; Consultations; Custom; Cyclic GMP; DNA; Data; Data Collection; Databases; Development; Developmental Disabilities; Diagnostic; Down Syndrome; Electronic Health Record; Enrollment; Equipment; Evaluation; Fragile X Syndrome; Future; Health; Health system; Hospitals; Human; Individual; Infant; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Intervention; Measurement; Modeling; Nursery Schools; Participant; Phenotype; Plasmids; Population; Process; Proteins; Recording of previous events; Registries; Research; Research Personnel; Research Proposals; Resources; Services; Specimen; Supervision; Technology; Therapeutic; Training; Translational Research; Translations; Traumatic Brain Injury; Universities; Video Recording; Virus; autism spectrum disorder; behavior test; biobank; biobehavior; cohort; computerized data processing; cost effective; design; disability; early childhood; experimental study; individuals with autism spectrum disorder; innovation; interest; laboratory equipment; method development; new technology; programs; psychologic; recruit; response; software development; therapy development; virtual; visual tracking

The Clinical Translational Core (CTC) promotes the use of, provides access to, and supports state-of-the-art technologies and resources to facilitate translation of basic science discoveries to the clinical setting, treatment development, clinical trials, and community practice. Indeed, the Waisman Center has always focused on clinical and translational research as one of the IDDRCs that contains a UCEDD (University Center of Excellence in Developmental Disabilities), including eleven diagnostic and treatment clinics operated in partnership with the two adjoining hospitals of the UW Health system and an inclusive model preschool program-the Waisman Early Childhood Program (WECP). Our history of interactions between research and clinical services continues to the present with studies of assessments, treatments, and interventions in conditions such as traumatic brain injury, blindness, Down syndrome, and autism spectrum disorder. Our Core incorporates new technologies and resources in biomedical research and serves as a focal point for cost- effective and innovative translational research related to intellectual and developmental disabilities (IDD) on our campus. The CTC has strong expertise in addressing challenges facing investigators who conduct behavioral and bio-behavioral research on IDD populations. Such populations present challenges to recruitment, require diagnostic evaluations by professionals with highly specialized training, and often involve assessment via innovative measurement strategies designed to focus specifically on the construct of interest and accessible to individuals with various types of disabilities; thus, linkages between basic, clinical and community applications of research in this area are critical. The CTC assists investigators with these and other challenges in the areas of recruitment, assessment, and behavioral methods development and applications. The CTC was dramatically enhanced within the last year by the development and implementation of a biobank to collect, store and make accessible for research biospecimens, clinical data, and health information from individuals with IDD. We have expanded our clinical research coordination and navigation services and we have upgraded our audio/video recording equipment for our behavioral testing suites. In response to COVID- 19, we have increased our clinical assessment and custom application services to support innovations needed for virtual data collection. Our specific aims for the next project period are to provide (1) support recruitment of human participants and provide access to data/specimens for behavioral, biobehavioral, and biomedical research and clinical trials, including capacity for cGMP biomanufacturing; (2) provide research coordination and navigation services; (3) provide specialized clinical assessments of individuals with IDD; and (4) provide behavioral methods development and custom applications.

临床翻译核心（CTC）促进使用，提供访问，并支持最先进的 技术和资源，以促进基础科学发现转化为临床环境，治疗 临床试验和社区实践。事实上，魏斯曼中心一直专注于 临床和转化研究作为IDDRC之一，其中包含UCEDD（大学中心） 发展性残疾卓越），包括11个诊断和治疗诊所 与华盛顿大学卫生系统的两家毗邻医院和一个包容性的示范幼儿园建立伙伴关系 Waisman Early Childhood Program（WECP）。我们的研究与 临床服务继续到现在的评估，治疗和干预的研究， 例如创伤性脑损伤、失明、唐氏综合症和自闭症谱系障碍。我们的核心 将新技术和资源纳入生物医学研究，并作为成本的焦点， 与智力和发育障碍（IDD）有关的有效和创新的翻译研究， 我们的校园反恐委员会在应对调查人员所面临的挑战方面具有很强的专门知识， 对缺碘人群的行为和生物行为研究。这些人口对 招聘，需要由受过高度专业培训的专业人员进行诊断评估，并经常涉及 通过创新的测量策略进行评估，专门针对感兴趣的结构 因此，基础、临床和 这一领域的研究成果在社区的应用至关重要。反恐委员会协助调查人员进行这些和其他工作， 在招聘，评估和行为方法的开发和应用领域的挑战。 在过去一年中，通过开发和实施生物库，反恐委员会得到了极大的加强 收集、储存和提供研究生物标本、临床数据和健康信息， IDD患者。我们扩大了临床研究协调和导航服务， 已经升级了我们行为测试套件的音频/视频记录设备。为了应对COVID- 19，我们增加了临床评估和定制应用服务，以支持所需的创新 用于虚拟数据收集。我们在下一个项目期间的具体目标是：（1）支持招聘 人类参与者，并提供对行为、生物行为和生物医学数据/样本的访问 研究和临床试验，包括cGMP生物制造能力;（2）提供研究协调 （3）为缺碘症患者提供专门的临床评估;以及（4）提供 行为方法开发和定制应用程序。