Scientific Core

科学核心

• 批准号: 10450035
• 负责人: Kiran Bhaskar
• 金额: $ 39.1万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10450035
• 关键词: Address; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease diagnostic; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; American Indians; Amyloid; Amyloid beta-Protein; Area; Award; Biological Assay; Biological Markers; Blood; Cancer Center; Caucasians; Clinical Services; Communities; Country; Data; Dementia; Deposition; Diagnosis; Diffusion Magnetic Resonance Imaging; Disease; Education; Funding; Future; Goals; Grant; Image; Impaired cognition; Incidence; Inflammatory; Institution; Latino; Latino Population; Lead; Leukoaraiosis; Liquid substance; Magnetic Resonance Imaging; Measurement; Metalloproteases; Methods; Nerve Degeneration; New Mexico; Pathway interactions; Patients; Pattern; Persons; Phase; Play; Population; Populations at Risk; Predictive Analytics; Protocols documentation; Research; Research Personnel; Resources; Risk; Rural; Sampling; Scientist; Services; Socioeconomic Status; Standardization; Stratification; Technology; Testing; United States; United States National Institutes of Health; Universities; Vascular Dementia; Vascular Diseases; base; biomarker panel; blood-brain barrier permeabilization; cerebrovascular; clinical diagnosis; cohort; contrast enhanced; data sharing; dementia risk; diagnostic criteria; endophenotype; health care availability; health disparity; imaging capabilities; imaging modality; improved; innovation; neuroimaging; new technology; novel; novel marker; outreach; patient population; programs; racial and ethnic; racial diversity; ranpirnase; rural Americans; screening; socioeconomics; study population; tau Proteins; tool; urban Native American; white matter

PROJECT SUMMARY – Scientific Core In support of the New Mexico Exploratory Alzheimer’s Disease Research Center (NM eADRC), the Scientific Core will centralize and expand existing expertise on Alzheimer’s disease biomarker research to the rural and urban American Indian (AI) communities in New Mexico. Specifically, the Scientific Core will establish ADNI- compatible, cerebrovascular focused neuroimaging, standardized assays for Aβ, tau and matrix metalloproteases (MMPs) in the blood and CSF samples and developing predictive analytics to distinguish different dementias in the rural and urban AI communities. Additional goals of the Scientific Core are to co- ordinate with the administrative core to have the biomarker data deposited to NACC and NCRAD, provide services to qualified investigators at University of New Mexico, across different institutions in the state and from other ADRCs/institutions across the nation. The Scientific Core also propose to expand the pool of dementia researchers by patterning with other centers/signature programs at the UNM and initiating new pilot programs on novel biomarkers/pathways related to Alzheimer’s disease and related disorders (AD/ADRD) research. The Scientific Core will support the NM eADRC to address one of the most important aspects of National Alzheimer’s Project Act on health disparities by successfully performing endophenotyping of the ‘at risk’ AI cohort. These goals will improve the limited screening clinical services available for dementia risk in AI population and also increase the representation of AI population in dementia research. These goals will be achieved by the Scientific Core under three specific aims. Aim 1: To provide expertise in magnetic resonance imaging (MRI) methods for understanding vascular contributions to dementia in Alzheimer’s disease and related disorders. Aim 2. To establish standardized assays for blood and CSF biomarker measurements for the dementia diagnosis and to develop and develop/test novel biomarkers that are currently used in the NIH- funded multi-center MarkVCID consortium study. Aim 3: Lead, coordinate, and develop dementia research across UNM and around the state via partnerships and pilot grant funding to carryout AD/ADRD research. Impact: Successful completion of all three specific aims of the Scientific Core will address one of the important gaps of test establish relationship across diverse racial, ethnic and socioeconomic backgrounds for dementia research, expand dementia research in NM and thus be ready for the P30 phase of ADRC in New Mexico in the near future.

项目摘要——科学核心 为了支持新墨西哥州探索性阿尔茨海默病研究中心 (NM eADRC)，科学 Core 将集中并将现有的阿尔茨海默病生物标志物研究专业知识扩展到农村和农村地区。 新墨西哥州的城市美洲印第安人 (AI) 社区。具体来说，科学核心将建立 ADNI- 兼容的脑血管聚焦神经影像、Aβ、tau 和基质标准化检测 血液和脑脊液样本中的金属蛋白酶 (MMP) 并开发预测分析来区分 农村和城市人工智能社区的不同痴呆症。科学核心的其他目标是共同 与行政核心协调，将生物标志物数据存入 NACC 和 NCRAD，提供 为新墨西哥大学、该州不同机构的合格研究人员提供服务 全国其他 ADRC/机构。科学核心还建议扩大痴呆症的范围 研究人员通过与新墨西哥州其他中心/签名项目进行模式合作并启动新的试点项目 与阿尔茨海默病和相关疾病 (AD/ADRD) 研究相关的新型生物标志物/通路。这 科学核心将支持 NM eADRC 解决国家战略最重要的方面之一 阿尔茨海默病项目通过成功对“高危”人工智能进行内表型分析来解决健康差异 队列。这些目标将改善人工智能中痴呆风险可用的有限筛查临床服务 人口，还增加了痴呆症研究中人工智能人群的代表性。这些目标将是 科学核心在三个具体目标下实现了这一目标。目标 1：提供磁共振方面的专业知识 成像 (MRI) 方法可了解血管对阿尔茨海默氏病痴呆的影响 相关疾病。目标 2. 建立血液和脑脊液生物标志物测量的标准化测定方法 痴呆症诊断以及开发和开发/测试目前在 NIH 中使用的新型生物标志物 资助多中心 MarkVCID 联盟研究。目标 3：领导、协调和发展痴呆症研究 通过合作伙伴关系和试点拨款资助，在新墨西哥州和全州各地开展 AD/ADRD 研究。 影响：成功完成科学核心的所有三个具体目标将解决其中一个重要问题 测试差距建立了不同种族、民族和社会经济背景之间痴呆症的关系 研究，扩大新墨西哥州的痴呆症研究，从而为新墨西哥州 ADRC 的 P30 阶段做好准备 不久的将来。