Scientific Core

项目摘要--科学核心 为了支持新墨西哥州探索性阿尔茨海默病研究中心(NM EADRC)，科学部 CORE将集中和扩展阿尔茨海默病生物标记物研究的现有专业知识到农村和 新墨西哥州的城市美国印第安人(AI)社区。具体来说，科学核心将建立ADNI- 兼容、脑血管聚焦的神经成像，Aβ、tau和基质的标准化分析 血液和脑脊液样本中的金属蛋白酶(MMPs)和发展预测分析以区分 农村和城市人工智能社区中的不同痴呆症。科学核心的其他目标是共同 与行政核心协调，将生物标志物数据存储到NACC和NCRAD，提供 为新墨西哥大学合格的调查人员提供服务，涉及该州不同的机构和 全国其他ADRC/机构。科学核心组织还建议扩大痴呆症的范围 研究人员通过与UNM的其他中心/签名计划建立模式并启动新的试点计划 与阿尔茨海默病和相关疾病(AD/ADRD)相关的新生物标记物/途径的研究。这个 Science Core将支持NM eADRC解决国家最重要的方面之一 阿尔茨海默氏症项目通过成功地对处于危险中的人工智能进行内表型分析来解决健康差异 一群人。这些目标将改善人工智能中有限的痴呆症风险筛查临床服务 也增加了人工智能群体在痴呆症研究中的代表性。这些目标将是 科学核心在三个具体目标下实现。目标1：提供磁共振方面的专业知识 了解血管对阿尔茨海默病痴呆的影响的成像(MRI)方法 相关的障碍。目的2.建立血液和脑脊液生物标记物测定的标准化方法 痴呆的诊断，并开发和开发/测试目前用于NIH的新型生物标记物- 资助的多中心MarkVCID财团研究。目标3：领导、协调和发展痴呆症研究 在整个UNM和全州范围内，通过伙伴关系和试点赠款资金开展AD/ADRD研究。 影响：成功完成科学核心的所有三个具体目标将解决重要的 测试的差距建立了不同种族、民族和社会经济背景与痴呆症的联系 研究，扩大NM的痴呆症研究，从而为#年在新墨西哥州举行的ADRC P30阶段做好准备 在不久的将来。

PROJECT SUMMARY – Scientific Core In support of the New Mexico Exploratory Alzheimer’s Disease Research Center (NM eADRC), the Scientific Core will centralize and expand existing expertise on Alzheimer’s disease biomarker research to the rural and urban American Indian (AI) communities in New Mexico. Specifically, the Scientific Core will establish ADNI- compatible, cerebrovascular focused neuroimaging, standardized assays for Aβ, tau and matrix metalloproteases (MMPs) in the blood and CSF samples and developing predictive analytics to distinguish different dementias in the rural and urban AI communities. Additional goals of the Scientific Core are to co- ordinate with the administrative core to have the biomarker data deposited to NACC and NCRAD, provide services to qualified investigators at University of New Mexico, across different institutions in the state and from other ADRCs/institutions across the nation. The Scientific Core also propose to expand the pool of dementia researchers by patterning with other centers/signature programs at the UNM and initiating new pilot programs on novel biomarkers/pathways related to Alzheimer’s disease and related disorders (AD/ADRD) research. The Scientific Core will support the NM eADRC to address one of the most important aspects of National Alzheimer’s Project Act on health disparities by successfully performing endophenotyping of the ‘at risk’ AI cohort. These goals will improve the limited screening clinical services available for dementia risk in AI population and also increase the representation of AI population in dementia research. These goals will be achieved by the Scientific Core under three specific aims. Aim 1: To provide expertise in magnetic resonance imaging (MRI) methods for understanding vascular contributions to dementia in Alzheimer’s disease and related disorders. Aim 2. To establish standardized assays for blood and CSF biomarker measurements for the dementia diagnosis and to develop and develop/test novel biomarkers that are currently used in the NIH- funded multi-center MarkVCID consortium study. Aim 3: Lead, coordinate, and develop dementia research across UNM and around the state via partnerships and pilot grant funding to carryout AD/ADRD research. Impact: Successful completion of all three specific aims of the Scientific Core will address one of the important gaps of test establish relationship across diverse racial, ethnic and socioeconomic backgrounds for dementia research, expand dementia research in NM and thus be ready for the P30 phase of ADRC in New Mexico in the near future.