Scientific Core

科学核心

• 批准号: 10038022
• 负责人: Kiran Bhaskar
• 金额: $ 26.19万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10038022
• 关键词: Address; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; American Indians; Amyloid; Amyloid beta-Protein; Area; Award; Biological Assay; Biological Markers; Blood; Cancer Center; Caucasians; Clinical Services; Communities; Country; Data; Dementia; Deposition; Diagnosis; Diagnostic; Diffusion Magnetic Resonance Imaging; Disease; Education; Funding; Future; Goals; Grant; Image; Impaired cognition; Incidence; Inflammatory; Institution; Latino; Lead; Leukoaraiosis; Liquid substance; Magnetic Resonance Imaging; Measurement; Metalloproteases; Methods; Nerve Degeneration; New Mexico; Pathway interactions; Patients; Pattern; Phase; Play; Population; Populations at Risk; Predictive Analytics; Protocols documentation; Research; Research Personnel; Resources; Risk; Rural; Sampling; Scientist; Services; Socioeconomic Status; Standardization; Stratification; Technology; Testing; United States; United States National Institutes of Health; Universities; Vascular Dementia; Vascular Diseases; base; biomarker panel; blood-brain barrier permeabilization; cerebrovascular; clinical Diagnosis; cohort; contrast enhanced; data sharing; dementia risk; endophenotype; health care availability; health disparity; imaging capabilities; imaging modality; improved; innovation; neuroimaging; new technology; novel; novel marker; outreach; patient population; programs; racial and ethnic; racial diversity; ranpirnase; rural Americans; screening; socioeconomics; study population; tau Proteins; tool; urban Native American; white matter

PROJECT SUMMARY – Scientific Core In support of the New Mexico Exploratory Alzheimer’s Disease Research Center (NM eADRC), the Scientific Core will centralize and expand existing expertise on Alzheimer’s disease biomarker research to the rural and urban American Indian (AI) communities in New Mexico. Specifically, the Scientific Core will establish ADNI- compatible, cerebrovascular focused neuroimaging, standardized assays for Aβ, tau and matrix metalloproteases (MMPs) in the blood and CSF samples and developing predictive analytics to distinguish different dementias in the rural and urban AI communities. Additional goals of the Scientific Core are to co- ordinate with the administrative core to have the biomarker data deposited to NACC and NCRAD, provide services to qualified investigators at University of New Mexico, across different institutions in the state and from other ADRCs/institutions across the nation. The Scientific Core also propose to expand the pool of dementia researchers by patterning with other centers/signature programs at the UNM and initiating new pilot programs on novel biomarkers/pathways related to Alzheimer’s disease and related disorders (AD/ADRD) research. The Scientific Core will support the NM eADRC to address one of the most important aspects of National Alzheimer’s Project Act on health disparities by successfully performing endophenotyping of the ‘at risk’ AI cohort. These goals will improve the limited screening clinical services available for dementia risk in AI population and also increase the representation of AI population in dementia research. These goals will be achieved by the Scientific Core under three specific aims. Aim 1: To provide expertise in magnetic resonance imaging (MRI) methods for understanding vascular contributions to dementia in Alzheimer’s disease and related disorders. Aim 2. To establish standardized assays for blood and CSF biomarker measurements for the dementia diagnosis and to develop and develop/test novel biomarkers that are currently used in the NIH- funded multi-center MarkVCID consortium study. Aim 3: Lead, coordinate, and develop dementia research across UNM and around the state via partnerships and pilot grant funding to carryout AD/ADRD research. Impact: Successful completion of all three specific aims of the Scientific Core will address one of the important gaps of test establish relationship across diverse racial, ethnic and socioeconomic backgrounds for dementia research, expand dementia research in NM and thus be ready for the P30 phase of ADRC in New Mexico in the near future.

项目概要-科学核心 为了支持新墨西哥州探索性阿尔茨海默病研究中心（NM eADRC）， 核心将集中和扩大现有的专门知识对阿尔茨海默病的生物标志物研究，以农村和 新墨西哥州的城市印第安人社区。具体而言，科学核心将建立ADNI- 兼容的脑血管聚焦神经成像，Aβ、tau和基质的标准化测定 血液和CSF样本中的金属蛋白酶（MMPs），并开发预测分析以区分 不同的痴呆症在农村和城市AI社区。科学核心的其他目标是共同- 与行政核心协调，将生物标志物数据存入NACC和NCRAD，提供 为新墨西哥州大学的合格调查人员提供服务，包括该州不同机构的调查人员，以及来自 全国各地的其他ADRC/机构。科学核心还建议扩大痴呆症的范围， 研究人员通过与UNM的其他中心/签名计划合作并启动新的试点计划 与阿尔茨海默病和相关疾病（AD/ADRD）研究相关的新生物标志物/途径。的 科学核心将支持NM eADRC解决国家最重要的方面之一， 阿尔茨海默氏症项目通过成功地对“高危”AI进行内表型分析来消除健康差异 队列。这些目标将改善AI中痴呆风险的有限筛查临床服务 人口，并增加AI人口在痴呆症研究中的代表性。这些目标将是 科学核心在三个具体目标下实现。目标1：提供磁共振方面的专业知识 用于了解血管对阿尔茨海默病痴呆的作用的MRI方法， 相关疾病。目标2.建立血液和CSF生物标志物测量的标准化测定， 痴呆症的诊断，并开发和开发/测试目前在美国国立卫生研究院使用的新的生物标志物， 多中心MarkVCID联盟研究。目标3：领导、协调和发展痴呆症研究 通过伙伴关系和试点赠款资助，在整个新墨西哥州和全州开展AD/ADRD研究。 影响：成功完成科学核心的所有三个具体目标将解决其中一个重要问题， 测试的差距建立了不同种族，民族和社会经济背景之间的关系， 研究，扩大痴呆症研究在新墨西哥州，从而为P30阶段的ADRC在新墨西哥州在 不久的将来