Couples Managing Early-Stage Dementia: Mutual Influences on Daily Stress, Self-Care, and Well-Being

项目总结 阿尔茨海默病和相关痴呆症(ADRD)目前是一个日益严重的公共卫生问题 影响到500多万美国成年人和大约300万配偶照顾者。这个项目延伸了 关于照顾者压力和健康结果的研究，以考虑日常压力、自我护理和 管理ADRD早期阶段的夫妻幸福，这可能是一个需要保存的关键时间窗口 关心每一位伴侣的幸福。人们越来越认识到早期干预和自我护理的价值 在ADRD患者及其照顾者中的战略，反映了提高认识的紧迫性 护理二元组中的早期相互影响，为干预措施提供信息，以维持其最佳健康和 功能正常。拟议的导师职业发展奖结合了一项严格的研究计划， 指导和教学，以促进候选人的成长，朝着成为一名 独立调查人员专注于为接受复杂护理的老年夫妇提供干预设计的信息 包括ADRD在内的需要改善双方的福祉。培训目标将帮助应聘者 获得：1)ADRD患者和他们的临床护理和教育需求的扎实知识 配偶将为将研究成果转化为有针对性的干预措施奠定基础；2) 具备评估、分析和解释潜在压力生物测量的专业技能 将ADRD护理情况与健康和福祉联系起来的机制；3)熟练使用密集药物 重复的措施设计，将产生关于穷人的近期风险和保护因素的新信息 护理二元组内的结果。培训的目的是寻求进一步发展应聘者作为 在晚年配偶照料关系领域的跨学科研究人员，并与 研究的目的是：1)检查自己和伴侣关于日常压力源、自我照顾和健康状况的报告之间的联系 在照顾范围内；2)确定自己和伴侣报告的日常压力源和 护理二人组内压力的生物测量；以及3)确定哪些个人和夫妇或多或少 通过评估心理社会资源(自我效能、两难应对和婚姻质量)对压力的弹性 在二元组中，日常压力、自我照顾和幸福感之间的联系是适度的。调查结果将会产生 关于日常相互影响对管理夫妇的积极和消极结果的关键知识 早期ADRD，告知有针对性的干预措施，以促进两个护理伙伴的福祉。

PROJECT SUMMARY Alzheimer's disease and related dementias (ADRD) are an increasing public health concern, currently affecting over 5 million US adults and approximately 3 million of their spousal caregivers. This project extends research on caregiver stress and health outcomes to consider the relations among daily stress, self-care, and well-being within couples managing the early stages of ADRD, a potentially critical time window to preserve each care partner's well-being. There is growing recognition for the value of early intervention and self-care strategies among persons with ADRD and their caregivers, reflecting the urgency for greater awareness of early mutual influences within care dyads that inform interventions to maintain their optimal health and functioning. The proposed mentored career development award combines a rigorous program of research, mentorship, and didactics to facilitate the candidate's growth toward an overall career goal of becoming an independent investigator focused on informing the design of interventions for aging couples with complex care needs including ADRD to improve both partners' well-being. The training aims will assist the candidate in acquiring: 1) grounded knowledge of clinical care and educational needs for persons with ADRD and their spouses that will provide a foundation for translating research findings into targeted interventions; 2) specialized skills in the assessment, analysis, and interpretation of biomeasures of stress that are potential mechanisms linking the ADRD care situation to health and well-being; and 3) proficiency in the use of intensive repeated measures designs that will generate novel information on proximal risk and protective factors for poor outcomes within care dyads. The training aims seek to further develop the candidate's expertise as an interdisciplinary researcher in the area of later-life spousal caregiving relationships and align closely with the research aims to: 1) examine the links among own and partner reports of daily stressors, self-care, and well- being within care dyads; 2) determine the links among own and partner reports of daily stressors and biomeasures of stress within care dyads; and 3) identify which individuals and couples are more or less resilient to stress by evaluating how psychosocial resources (self-efficacy, dyadic coping, and marital quality) within dyads moderate the associations among daily stress, self-care, and well-being. The findings will yield key knowledge of everyday mutual influences on positive and negative outcomes among couples managing early-stage ADRD, informing targeted interventions to promote the well-being of both care partners.