Examining the mechanisms of anxiety regulation using a novel, sham-controlled, fMRI-guided rTMS protocol and a translational laboratory model of anxiety.
使用新型假对照、功能磁共振成像引导的 rTMS 方案和焦虑的转化实验室模型来检查焦虑调节机制。
基本信息
- 批准号:10452521
- 负责人:
- 金额:$ 18.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-17 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:Amygdaloid structureAnteriorAnxietyAnxiety DisordersArousalBenzodiazepinesClinicalCollectionDataDiagnosisDiseaseDrug Side EffectsEmotionsFrequenciesFrightFunctional Magnetic Resonance ImagingFundingFutureGrantHealthcare SystemsImpairmentIndividualInsula of ReilLaboratoriesLeadLinkMeasuresMediatingMemory impairmentModelingNeurobehavioral ManifestationsNeuronavigationParticipantPathological anxietyPatient Self-ReportPatientsPerformancePharmacological TreatmentPhysiologic pulsePrefrontal CortexProtocols documentationPsychophysiologyPublic HealthRegulationResearchRoleSelective Serotonin Reuptake InhibitorShockShort-Term MemoryStructureStructure of terminal stria nuclei of preoptic regionSymptomsTechniquesTestingTranslatingUnited States National Institutes of HealthWorkanxiety statesanxiety symptomsanxiety treatmentanxiousblood oxygen level dependentblood oxygenation level dependent responsecareercognitive taskelectric fieldexperienceimprovedinnovationneurobiological mechanismneuroimagingneuromechanismneuroregulationnovelprimary outcomeprogramsrepetitive transcranial magnetic stimulationtherapy developmenttreatment adherence
项目摘要
Although extensive research has explored the involvement of subcortical structures in arousal, arousal
symptoms are only one facet of the symptom profile shared across anxiety disorders. Much less is known
about the cognitive symptoms (i.e. difficulty concentrating) experienced by anxiety patients. Accordingly, there
is a critical need for mechanistic research into the CNS mechanisms that mediate the cognitive symptoms
experienced by anxiety patients. Without such research, treatment development for these disorders will
continue to make slow progress. The objective of this application is to determine the key neural mechanisms
that mediate the cognitive symptoms of anxiety. My central hypothesis is that the right dorsolateral prefrontal
cortex (dlPFC) regulates emotion through top-down inhibition of emotion-related regions. My approach will be
to use repetitive transcranial magnetic stimulation (rTMS) to study the effect of right dlPFC activity on objective
and subjective measures of induced anxiety, anxiety-related working memory deficits (WM), and TMS-evoked
blood oxygenation-level dependent (BOLD) responses during simultaneous TMS/fMRI (i.e. target
engagement). My rationale for this approach is that by experimentally manipulating right dlPFC activity using
rTMS, I will be able to causally demonstrate involvement of this region in anxiety regulation, which could
translate to future targeted rTMS treatments for anxiety. My first aim will be to determine the effect of a 1-week
course of rTMS treatment (1 Hz vs. 10 Hz; right dlPFC target) on anxiety using the threat of unpredictable
shock paradigm. My second aim will be to determine the effect of a 1-week course of rTMS treatment (1 Hz vs.
10 Hz; right dlPFC target) on anxiety-related WM-deficits using the Sternberg WM paradigm during threat of
shock. My third aim will be to demonstrate target engagement by measuring BOLD responses evoked by TMS
pulses to the right dlPFC during threat of shock. The work is innovative because it will combine advanced
neuromodulatory techniques (fMRI guidance, electric-field modelling, neuronavigation, active-sham control)
with a translational threat of shock paradigm.
尽管广泛的研究已经探索了皮层下结构在唤醒中的参与,但唤醒
症状只是焦虑症共有症状的一个方面。知之甚少
关于焦虑症患者所经历的认知症状(即注意力不集中)。据此,有
迫切需要对介导认知症状的中枢神经系统机制进行机制研究
焦虑症患者所经历的。如果没有这样的研究,这些疾病的治疗方法的开发将会
继续取得缓慢的进展。该应用程序的目的是确定关键的神经机制
介导焦虑的认知症状。我的中心假设是右背外侧前额叶
皮质(dlPFC)通过自上而下抑制情绪相关区域来调节情绪。我的方法是
使用重复经颅磁刺激(rTMS)研究右侧 dlPFC 活动对客观的影响
诱发焦虑、焦虑相关工作记忆缺陷 (WM) 和 TMS 诱发的主观测量
同时 TMS/fMRI 期间的血氧水平依赖性 (BOLD) 反应(即目标
订婚)。我采用这种方法的理由是,通过使用 dlPFC 实验操纵右 dlPFC 活动
rTMS,我将能够因果地证明该区域参与焦虑调节,这可能
转化为未来针对焦虑症的针对性 rTMS 治疗。我的首要目标是确定 1 周的效果
使用不可预测的威胁对焦虑进行 rTMS 治疗过程(1 Hz 与 10 Hz;右侧 dlPFC 目标)
震惊范式。我的第二个目标是确定 1 周 rTMS 治疗疗程的效果(1 Hz 与 1 Hz)。
10赫兹;正确的 dlPFC 目标)在威胁期间使用 Sternberg WM 范式处理与焦虑相关的 WM 缺陷
震惊。我的第三个目标是通过测量 TMS 引起的大胆反应来证明目标参与度
在受到电击威胁时向右侧 dlPFC 发出脉冲。这项工作具有创新性,因为它将结合先进的
神经调节技术(功能磁共振成像引导、电场建模、神经导航、主动假控制)
具有休克范式的转化威胁。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Patients with anxiety disorders rely on bilateral dlPFC activation during verbal working memory.
- DOI:10.1093/scan/nsaa146
- 发表时间:2020-12-24
- 期刊:
- 影响因子:4.2
- 作者:Balderston NL;Flook E;Hsiung A;Liu J;Thongarong A;Stahl S;Makhoul W;Sheline Y;Ernst M;Grillon C
- 通讯作者:Grillon C
Continuous Theta-Burst Stimulation to the Right Dorsolateral Prefrontal Cortex May Increase Potentiated Startle in Healthy Individuals.
- DOI:10.1016/j.bpsgos.2022.04.001
- 发表时间:2023-07
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
A generalized workflow for conducting electric field-optimized, fMRI-guided, transcranial magnetic stimulation.
- DOI:10.1038/s41596-020-0387-4
- 发表时间:2020-11
- 期刊:
- 影响因子:14.8
- 作者:Balderston NL;Roberts C;Beydler EM;Deng ZD;Radman T;Luber B;Lisanby SH;Ernst M;Grillon C
- 通讯作者:Grillon C
Proof of concept study to develop a novel connectivity-based electric-field modelling approach for individualized targeting of transcranial magnetic stimulation treatment.
- DOI:10.1038/s41386-021-01110-6
- 发表时间:2022-01
- 期刊:
- 影响因子:0
- 作者:Balderston NL;Beer JC;Seok D;Makhoul W;Deng ZD;Girelli T;Teferi M;Smyk N;Jaskir M;Oathes DJ;Sheline YI
- 通讯作者:Sheline YI
Threat of shock increases distractor susceptibility during the short-term maintenance of visual information.
在视觉信息的短期维持过程中,电击的威胁会增加干扰物的敏感性。
- DOI:10.1101/2023.11.22.23298914
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Casalvera,Abigail;Goodwin,Madeline;Lynch,Kevin;Teferi,Marta;Patel,Milan;Grillon,Christian;Ernst,Monique;Balderston,NicholasL
- 通讯作者:Balderston,NicholasL
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nicholas LEE balderston其他文献
nicholas LEE balderston的其他文献
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{{ truncateString('nicholas LEE balderston', 18)}}的其他基金
Novel electric-field modelling approach to quantify changes in resting state functional connectivity following theta burst stimulation
新颖的电场建模方法可量化 θ 爆发刺激后静息态功能连接的变化
- 批准号:
10686090 - 财政年份:2022
- 资助金额:
$ 18.08万 - 项目类别:
Examining the mechanisms of anxiety regulation using a novel, sham-controlled, fMRI-guided rTMS protocol and a translational laboratory model of anxiety.
使用新型假对照、功能磁共振成像引导的 rTMS 方案和焦虑的转化实验室模型来检查焦虑调节机制。
- 批准号:
10207409 - 财政年份:2019
- 资助金额:
$ 18.08万 - 项目类别:
Examining the mechanisms of anxiety regulation using a novel, sham-controlled, fMRI-guided rTMS protocol and a translational laboratory model of anxiety.
使用新型假对照、功能磁共振成像引导的 rTMS 方案和焦虑的转化实验室模型来检查焦虑调节机制。
- 批准号:
10018954 - 财政年份:2019
- 资助金额:
$ 18.08万 - 项目类别:
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