Research & Methods Core

研究

• 批准号: 10454672
• 负责人: KATHERINE S PANAGEAS
• 金额: $ 34.13万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454672
• 关键词: Administrator; Adult; Algorithms; Ambulatory Care Facilities; Artificial Intelligence; Biological Markers; Biometry; Cancer Control; Caring; Clinical Trials; Clinical Trials Design; Communication; Complex; Custom; Data; Data Science; Development; Educational workshop; Electronic Health Record; Evaluation; Family; Goals; Health; Health Services Research; Health system; Healthcare; Healthcare Systems; Home; Hybrids; Immunooncology; Infrastructure; Intervention; Journals; Knowledge; Lead; Light; Machine Learning; Malignant neoplasm of prostate; Memorial Sloan-Kettering Cancer Center; Mentors; Methodology; Methods; Oncology; Ontology; Outcome Measure; Outcomes Research; Patient Outcomes Assessments; Patients; Peer Review; Pilot Projects; Play; Policies; Policy Maker; Postdoctoral Fellow; Predictive Analytics; Provider; Publications; Qualitative Methods; Randomized; Randomized Clinical Trials; Research; Research Methodology; Research Personnel; Resources; Source; Source Code; Standardization; Statistical Methods; Stream; Taxonomy; Training; Validation; Work; advanced analytics; analytical method; asynchronous encounter; base; cancer care; care delivery; career; data integration; data management; data standards; data streams; digital; digital delivery; effectiveness evaluation; electronic data; evidence base; experience; health data; innovation; insight; interoperability; malignant breast neoplasm; method development; multidimensional data; novel; open source; personalized cancer care; pragmatic trial; recruit; research and development; social media; symposium; synchronous contact; telehealth; telehealthcare; tool; treatment as usual; trial comparing; trial design; user-friendly; web site

PROJECT SUMMARY/ABSTRACT The MATCHES (Making Telehealth Delivery of Cancer Care at Home Effective and Safe) Telehealth Research Center aims to build the evidence base necessary to establish best practices for telehealth-supported cancer care. It will execute nimble, rigorously designed clinical trials investigating whether and how telehealth can enable more cancer care to be safely, effectively, and equitably provided in patients’ homes. The Research & Methods Core (RMC) is instrumental to the MATCHES research theme: focusing on the development of methods to integrate complex streams of multi-level data from asynchronous and synchronous encounters so as to evaluate the effectiveness and impact of telehealth. Specifically, the RMC will generate, refine, validate, and disseminate novel research methods and outcome measures for the evaluation of telehealth in oncology, including digital biomarkers based on digitally captured data and electronic patient-reported outcomes. These activities will directly advance our goal of developing a paradigm for personalized cancer care delivery. To this goal, the RMC brings high-level expertise, strong infrastructure, extensive resources, and immediately relevant experience in data management, mixed-methods research, biostatistics, advanced predictive analytics (e.g., machine learning, artificial intelligence), and clinical trial design. The RMC will be led by Katherine Panageas, DrPH, a biostatistician with deep expertise in trial design and health services research methods. She has led statistical coordinating centers for multiple large projects, including clinical trials and cancer control studies, and has evaluated complex care delivery innovations. The aims of the RMC are: 1) to provide high-quality data management for the development of research methods in telehealth, 2) to provide methodological and biostatistical support for the cluster-randomized Pragmatic Trial and for pilot studies evaluating MSK@Home, 3) to develop and apply novel statistical and research methods to aid evaluation of telehealth-supported cancer care delivery research and to train early-career investigators in these methods, and 4) to disseminate data, knowledge, and resources via user-friendly, open-source algorithms to accelerate broader implementation of telehealth-enabled home-based care. The RMC will develop a framework for processing and analyzing the multiple data streams generated in the context of telehealth-supported cancer care, as well as play a key role in reviewing and evaluating the research progress of the Center. It will also support the Pragmatic Trial and pilot studies and lead the selection and deployment of further telehealth pilot projects. The RMC will work closely with the MATCH-Light Training Unit of the Administrative Core to train junior investigators in research methods to advance telehealth research to drive personalized, equitable, and efficient oncology care and research.

项目摘要/摘要 远程医疗研究（使家庭有效且安全的癌症护理远程医疗服务）远程医疗研究 中心旨在建立必要的证据基础，以建立远程医疗癌症的最佳实践 关心。它将执行敏捷，严格设计的临床试验，以调查远程医疗是否可以 使更多的癌症护理能够安全，有效和同样提供在患者的家中。研究与 方法核心（RMC）对匹配研究主题有用：专注于发展 从异步和同步相遇中整合多层数据复杂流的方法 以评估远程医疗的有效性和影响。具体而言，RMC将生成，完善，验证， 并传播新的研究方法和结果指标，以评估肿瘤学的远程医疗， 包括基于数字捕获的数据和电子患者报告的结果，包括数字生物标志物。这些 活动将直接促进我们开发用于个性化癌症护理范围的范式的目标。对此 目标是，RMC带来了高级专业知识，强大的基础架构，广泛的资源，并且立即相关 具有数据管理的经验，混合方法研究，生物统计学，先进的预测分析（例如， 机器学习，人工智能）和临床试验设计。 RMC将由凯瑟琳·帕纳吉斯（Katherine Panageas）领导 DRPH，一位生物统计学家，在试验设计和卫生服务研究方法方面具有深厚的专业知识。她领导了 多个大型项目的统计协调中心，包括临床试验和癌症控制研究， 并评估了复杂的护理交付创新。 RMC的目的是：1）提供高质量的数据 管理远程医疗研究方法的发展，2）提供方法论和 为群集的务实试验和试点研究评估MSK@home的生物统计学支持， 3）开发和应用新颖的统计和研究方法来帮助评估远程医疗的癌症 护理交付研究和培训这些方法的早期研究人员，以及4）传播数据， 通过用户友好的开源算法进行知识和资源，以加速更广泛的实施 远程医疗的家庭护理。 RMC将开发一个用于处理和分析的框架 在远程医疗支持的癌症护理背景下生成的多个数据流，并发挥关键作用 在审查和评估中心的研究进度时。它还将支持务实的审判和 试点研究并领导进一步的远程医疗试点项目的选择和部署。 RMC将工作 与行政核心的比赛轻训练部门紧密接近研究培训研究人员 推进远程医疗研究以推动个性化，公平和高效的肿瘤学护理和 研究。